Rutin-loaded chitosan microspheres: Characterization and evaluation of the anti-inflammatory activity

Cosco, Donato; Failla, P.; Costa, Nicola; Pullano, Salvatore A.; Fiorillo, Antonino S.; Mollace, Vincenzo; Fresta, Massimo; Paolino, Donatella

doi:10.1016/j.carbpol.2016.06.039

Cited by 77 publications

(38 citation statements)

References 32 publications

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“…This indicates that rutin could be a candidate therapeutic agent for treatment of various severe vascular inflammatory diseases (45). In order to improve anti-inflammatory activity of the rutin, it was microencapsulated in a chitosan matrix using the spray-drying technique, and the resulting drug delivery system was investigated (46). We used a high dose of the nephrotoxic agent VCM, rending a poor clinical relevance to this particular study.…”

Section: Discussionmentioning

confidence: 99%

Rutin Attenuates Vancomycin-Induced Nephrotoxicity by Ameliorating Oxidative Stress, Apoptosis, and Inflammation in Rats

Dai

Lang

et al. 2019

Antimicrob Agents Chemother

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Nephrotoxicity is the major limiting factor for the clinical use of vancomycin (VCM) for treatment of serious infections caused by multiresistant Gram-positive bacteria. This study investigated the renal protective activity of rutin in a rat model of VCM-induced kidney injury in male Wistar rats. VCM administered intraperitoneally at 200 mg/kg twice daily for 7 successive days resulted in significant elevation of blood urea nitrogen and creatinine, as well as urinary N-acetyl-β-D-glucosaminidase. Coadministration of VCM with oral rutin at 150 mg/kg significantly reduced these markers of kidney damage. Rutin also significantly attenuated VCM-induced oxidative stress, inflammatory cell infiltration, apoptosis, and decreased interleukin-1β and tumor necrosis factor alpha levels (all P < 0.05 or 0.01) in kidneys. Renal recovery from VCM injury was achieved by rutin through increases in Nrf2 and HO-1 and a decrease in NF-κB expression. Our results demonstrated a protective effect of rutin on VCM-induced kidney injury through suppression of oxidative stress, apoptosis, and downregulation of the inflammatory response. This study highlights a role for oral rutin as an effective intervention to ameliorate nephrotoxicity in patients undergoing VCM therapy.

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Section: Discussionmentioning

confidence: 99%

Rutin Attenuates Vancomycin-Induced Nephrotoxicity by Ameliorating Oxidative Stress, Apoptosis, and Inflammation in Rats

Dai

Lang

et al. 2019

Antimicrob Agents Chemother

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“…Several studies have focused their attention on the modulation of the bioadhesive properties of poloxamer 407-gels by means of chitosan, a natural polysaccharide derived from the chitin of the exoskeletons of shrimp and crabs, which is widely used in pharmaceutical application [ 59 , 115 , 116 ]. The addition of chitosan improved the mucoadhesive characteristics and the gel strength of poloxamer-gels, due to the positively-charged amine residues of the compound, which promote a great deal of interaction with the negatively-charged mucous [ 101 ].…”

Section: Poloxamer 407-based Mucoadhesive Formulationsmentioning

confidence: 99%

Mucosal Applications of Poloxamer 407-Based Hydrogels: An Overview

et al. 2018

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Poloxamer 407, also known by the trademark Pluronic® F127, is a water-soluble, non-ionic triblock copolymer that is made up of a hydrophobic residue of polyoxypropylene (POP) between the two hydrophilic units of polyoxyethylene (POE). Poloxamer 407-based hydrogels exhibit an interesting reversible thermal characteristic. That is, they are liquid at room temperature, but they assume a gel form when administered at body temperature, which makes them attractive candidates as pharmaceutical drug carriers. These systems have been widely investigated in the development of mucoadhesive formulations because they do not irritate the mucosal membranes. Based on these mucoadhesive properties, a simple administration into a specific compartment should maintain the required drug concentration in situ for a prolonged period of time, decreasing the necessary dosages and side effects. Their main limitations are their modest mechanical strength and, notwithstanding their bioadhesive properties, their tendency to succumb to rapid elimination in physiological media. Various technological approaches have been investigated in the attempt to modulate these properties. This review focuses on the application of poloxamer 407-based hydrogels for mucosal drug delivery with particular attention being paid to the latest published works.

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“…The purpose of this investigation was to evaluate the influence of rutin on the stability and rheological features of P407-based hydrogels in order to obtain suitable systems for the in situ administration of the active compound. Rutin ( Figure S1 ), is a flavone glycoside characterized by a variety of biological and pharmacological activities, including anti-inflammatory and antioxidant properties, myocardial protection, antidiarrheal, antimutagenic and antitumor effects [ 25 , 26 ]. The main disadvantage related to the clinical application of rutin is its poor bioavailability, caused mainly by its poor water solubility [ 27 ].…”

Section: Introductionmentioning

confidence: 99%

Rutin-Loaded Poloxamer 407-Based Hydrogels for In Situ Administration: Stability Profiles and Rheological Properties

et al. 2020

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Rutin is a flavone glycoside contained in many plants, and exhibits antioxidant, anti-inflammatory, anticancer, and wound-healing properties. The main disadvantage related to the use of this molecule for pharmaceutical application is its poor bioavailability, due to its low solubility in aqueous media. Poloxamer 407-hydrogels show interesting thermo-sensitive properties that make them attractive candidates as pharmaceutical formulations. The hydrophobic domains in the chemical structure of the copolymer, a polymer made up of two or more monomer species, are useful for retaining poorly water-soluble compounds. In this investigation various poloxamer 407-based hydrogels containing rutin were developed and characterized as a function of the drug concentration. In detail, the Turbiscan stability index, the micro- and dynamic rheological profiles and in vitro drug release were investigated and discussed. Rutin (either as a free powder or solubilized in ethanol) did not modify the stability or the rheological properties of these poloxamer 407-based hydrogels. The drug leakage was constant and prolonged for up to 72 h. The formulations described are expected to represent suitable systems for the in situ application of the bioactive as a consequence of their peculiar versatility.

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Rutin-loaded chitosan microspheres: Characterization and evaluation of the anti-inflammatory activity

Cited by 77 publications

References 32 publications

Rutin Attenuates Vancomycin-Induced Nephrotoxicity by Ameliorating Oxidative Stress, Apoptosis, and Inflammation in Rats

Rutin Attenuates Vancomycin-Induced Nephrotoxicity by Ameliorating Oxidative Stress, Apoptosis, and Inflammation in Rats

Mucosal Applications of Poloxamer 407-Based Hydrogels: An Overview

Rutin-Loaded Poloxamer 407-Based Hydrogels for In Situ Administration: Stability Profiles and Rheological Properties

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