Ruxolitinib found to cause eyelash growth: a case report

Song, Julia; Song, Alice; Palmares, Trisa; Song, Michael; Song, Harold

doi:10.1186/s13256-017-1304-5

Cited by 16 publications

(10 citation statements)

References 24 publications

(11 reference statements)

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“…Previous reports tried to highlight the effect of other medications on hair growth, in a study of Song et al,24 they reported a case of unexpected eyelash growth much longer than they were normally, under the effect of ruxolitinib treatment. Also, in a study of Riahi et al,25 they reported excellent and sustained growth of eyebrows with continual daily use of bimatoprost 0.03% solution.…”

Section: Discussionmentioning

confidence: 99%

<p>Analysis of Bimatoprost-Induced changes on Rabbits eyelash Follicle: Clinical and Electron microscopic study</p>

Sayed

Mostafa

Mounir

et al. 2019

OPTH

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ObjectiveTo analyze ultrastructural changes of rabbits' eyelash follicles treated with bimatoprost eye drops to increase our knowledge of how this drug works.MethodsThe study included 15 clinically healthy male rabbits. All rabbits were treated with bimatoprost 0.03% daily for 4 weeks with one drop of the topical eye drops applied to the conjunctival fornix of the right eyes; left eyes were used as controls. Eyelash lengths were measured before and after treatment. The eyelid of each animal was dissected for light and electron microscopic analysis.ResultsBoth control and treated rabbit eyes matched regarding eyelash length before treatment (9.80±0.388mm vs 9.88±0.24mm) (P=0.108). There was a significant increase in eyelash length between control (9.75±0.33 mm) and treated rabbit eyes (11.60±0.46 mm) (P=0.369). Light and electron microscopy revealed, bimatoprost treated eyes had thick epidermis. The dermis contained two hairs growing out of the same hair follicle. Heavily keratinized Henle’s layer, the cortical cells (Cx) have prominent nucleolus and cytoplasm is studded with melanin granules.ConclusionBimatoprost-induced eyelash changes were not restricted to increased eyelash length, thickness, and pigmentation but also showed increased number of eyelashes within the same hair follicle which were stronger and could resist pulling from the skin without any evidence of inflammatory cells within the specimens. These changes occurred as early as 1 month of treatment, giving rise to thoughts about the possibility of using bimatoprost eye drops as a prophylaxis against madarosis associated with chemotherapy if it is started 1 month before chemotherapy and continued afterwards, making eyelashes stronger and resistant to falling out.

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Section: Discussionmentioning

confidence: 99%

<p>Analysis of Bimatoprost-Induced changes on Rabbits eyelash Follicle: Clinical and Electron microscopic study</p>

Sayed

Mostafa

Mounir

et al. 2019

OPTH

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“… 64 Eyelash growth was observed in a patient with hypereosinophilic syndrome after having taken ruxolitinib, but the responsible mechanism was not elucidated. 67 …”

Section: Ruxolitinibmentioning

confidence: 99%

Role of janus kinase inhibitors in the treatment of alopecia areata

Triyangkulsri¹,

Suchonwanit²

2018

DDDT

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Alopecia areata (AA) is a common hair loss disorder worldwide with characteristic exclamation mark hairs. Although AA is self-limited, it can last for several months or even years in some patients. Currently, there is no US Food and Drug Administration-approved treatment for AA. Many off-label treatments are available but with limited efficacy. Through a better understanding of molecular biology, many targeted therapies have emerged as new alternatives for various autoimmune diseases. Various janus kinase (JAK) and signal transducer and activator of transcription (STAT) proteins form signaling pathways, which transmit extracellular cytokine signals to the nucleus and induce DNA transcriptions. By inhibiting JAK, T-cell-mediated inflammatory responses are suppressed. Increasing evidence suggests that JAK inhibitors (JAKis) are effective in the treatment of many autoimmune diseases, including AA. Among these, several studies on tofacitinib, ruxolitinib, and baricitinib in AA had been published, demonstrating promising outcomes of these agents. Unlike oral formulations, efficacy of topical forms of tofacitinib and ruxolitinib reported in these studies is still unsatisfactory and requires improvement. This review aims to summarize evidence of the efficacy and safety of JAKis in the treatment of AA.

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“…They empirically showed the historic infection data of some known botnet that uses the same infection type with more than 80% accuracy. Jungsuk et al [69] showed cross analysis among 10 spamming botnet to analyze malware infected host. the external parameter.…”

Section: Irc Based Analysismentioning

confidence: 99%

Botnet Forensic: Issues, Challenges and Good Practices

Bijalwan

Solanki

Pilli

2018

NPA

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Unethical hacking of sites, probing, click frauds, phishing, denial of services attack and many such malicious practices affects the organizational integrity and sovereignty. Such activities are direct attacks on the safety, security and confidentiality of the organization. These activities put organizational privacy at stake. Botnet forensic is utilized to strengthen the security issues by understanding the modus operandi of the attacks. The available observations can be utilized in future also to prevent a potential threat to network security. This paper enlightens the novel summary of previous survey including life cycle, classification, framework, detection, analysis and the challenges for botnet forensics.

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Ruxolitinib found to cause eyelash growth: a case report

Cited by 16 publications

References 24 publications

<p>Analysis of Bimatoprost-Induced changes on Rabbits eyelash Follicle: Clinical and Electron microscopic study</p>

<p>Analysis of Bimatoprost-Induced changes on Rabbits eyelash Follicle: Clinical and Electron microscopic study</p>

Role of janus kinase inhibitors in the treatment of alopecia areata

Botnet Forensic: Issues, Challenges and Good Practices

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