S-100 Negative Granular Cell Tumor of the Oral Cavity

Abstract

Classic granular cell tumor is a mesenchymal neoplasm that commonly occurs on the skin, but is not infrequently found in the oral cavity, primarily on the dorsal tongue. Diagnosis is usually straightforward with hematoxylin and eosin stained slides. Immunohistochemical studies on classic granular cell tumor shows positive immunostaining for S-100 and vimentin, while CD68 is variably positive. We report a case of otherwise unremarkable oral granular cell tumor that was immunohistochemically negative for S-100, and positive for vimentin and CD68, and discuss the differential diagnosis. The results of the immunohistochemical studies in our case are compared with those of classic S-100 positive oral granular cell tumors, as well as cutaneous and oral S-100 negative granular cell tumors. Classic S-100 positive granular cell tumors and S-100 negative granular cell tumors of the oral cavity can only be distinguished by immunohistochemical studies; however, the necessity of this distinction is unclear, as both are benign lesions in which recurrence is unlikely.

S-100 Negative Granular Cell Tumor (So-called Primitive Polypoid Non-neural Granular Cell Tumor) of the Oral Cavity

“…From the histopathological examination (Table 2), it is seen that the removal was incomplete in 3 cases. This information was not available in 2 cases [12,13]. At the time of writing this manuscript, (24 and 6 months after removal, respectively), there has been no recurrence in our 2 cases.…”

“…The tumors were asymptomatic and presented as exophytic, red, nodular masses resembling a pyogenic granuloma. The clinical description of the tongue mass was not available [13]. History of trauma at the affected site was present in 2 cases, the case affecting the alveolar ridge reported by Lerman and Freedman [12] and case 2 from this paper.…”

“…The tongue lesion [13] was non-ulcerated. In areas, where some epithelium was seen, it was attenuated.…”

“…At the time of writing this manuscript, there are three case reports in English literature of documented oral involvement by the S-100 negative (non-neural) GCT [11][12][13]. This paper contributes two more cases of oral mucosal involvement by this unusual lesion.…”

“…The removal was incomplete in 3 cases and an epithelial collaret was not seen. This information was not available in 2 cases [12,13]. One tumor was described as being well-circumscribed although the removal was incomplete [11].…”