S-Antigen immunoreactivity in human pineal glands and pineal parenchymal tumors. A monoclonal antibody study

Perentes, Elias; Rubinstein, L. J.; Herman, Mary M.; Donoso, Larry A.

doi:10.1007/bf00688043

Cited by 68 publications

(20 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…5;Korf et al 1985bKorf et al , 1990. The S-antigen has also been used for characterization of pineal parenchymal tumors (Korf et al 1986;Perentes et al 1986). …”

Section: Anatomy Of the Mammalian Pineal Glandmentioning

confidence: 99%

The anatomy and innervation of the mammalian pineal gland

2002

View full text Add to dashboard Cite

The parenchymal cells of the mammalian pineal gland are the hormone-producing pinealocytes and the interstitial cells. In addition, perivascular phagocytes are present. The phagocytes share antigenic properties with microglial and antigen-presenting cells. In certain species, the pineal gland also contains neurons and/or neuron-like peptidergic cells. The peptidergic cells might influence the pinealocyte by a paracrine secretion of the peptide. Nerve fibers innervating the mammalian pineal gland originate from perikarya located in the sympathetic superior cervical ganglion and the parasympathetic sphenopalatine and otic ganglia. The sympathetic nerve fibers contain norepinephrine and neuropeptide Y as neurotransmitters. The parasympathetic nerve fibers contain vasoactive intestinal peptide and peptide histidine isoleucine. Recently, neurons in the trigeminal ganglion, containing substance P, calcitonin gene-related peptide, and pituitary adenylate cyclase-activating peptide, have been shown to project to the mammalian pineal gland. Finally, nerve fibers originating from perikarya located in the brain containing, for example, GABA, orexin, serotonin, histamine, oxytocin, and vasopressin innervate the pineal gland directly via the pineal stalk. Biochemical studies have demonstrated numerous receptors on the pinealocyte cell membrane, which are able to bind the neurotransmitters located in the pinealopetal nerve fibers. These findings indicate that the mammalian pinealocyte can be influenced by a plethora of neurotransmitters.

show abstract

“…5;Korf et al 1985bKorf et al , 1990. The S-antigen has also been used for characterization of pineal parenchymal tumors (Korf et al 1986;Perentes et al 1986). …”

Section: Anatomy Of the Mammalian Pineal Glandmentioning

confidence: 99%

The anatomy and innervation of the mammalian pineal gland

2002

View full text Add to dashboard Cite

show abstract

“…Some cells of the human pineal gland share with retinal cells the capacity to express the S antigen [34], This was used to explain the identification of retinoblastomatous features in some pineal region tumors. Positivity to retinal S anti gen has been documented in pineoblastomas, pineocytomas, and even medulloblastomas [35][36][37][38], Trilateral reti noblastoma is thought to result from the common photo receptor origin of the pineal gland and the retina, render ing both organs susceptible to 'hits' at the retinoblastoma gene site. Variants of trilateral retinoblastoma have been described.…”

Section: Pathogenesis O F Trilateral Retinoblastomasmentioning

confidence: 99%

Association of a Suprasellar Mass and Intraocular Retinoblastoma: A Variant of Pineal Trilateral Retinoblastoma?

Bejjani

Donahue

Selby³

et al. 1996

Pediatr Neurosurg

View full text Add to dashboard Cite

Objective and Importance: ‘Trilateral retinoblastoma’ designates the association of bilateral retinoblastomas with an ectopic (non-metastatic) intracranial primitive neuroectodermal tumor (PNET). Although the intracranial tumor, usually located in the pineal region, is seen 2-3 years after discovery of the bilateral ocular tumors, variant presentations do occur. The intraocular tumor can be unilateral, and the intracranial tumor can be suprasellar, presenting before the retinal lesions. Clinical Presentation: A 4-month-old boy presented with irritability, vomiting and nystagmus. Head CT revealed a large calcified sellar-suprasellar mass. Ocular examination disclosed white macular lesions in the right fundus. He was taken to surgery where subtotal resection of the sellar-suprasellar mass was achieved. Microscopic examination showed a primitive, small, round, blue cell tumor consistent with retinoblastoma. The right ocular lesions, also consistent with retinoblastoma, were treated by cryo-surgery. Conclusion: The appearance of a suprasellar PNET can precede the appearance of retinal masses in retinoblastoma. The literature suggests that patients with ‘sellar’ trilateral retinoblastoma have characteristics that differ from patients with a pineal region trilateral retinoblastoma: the intracranial mass more often presents initially; it occurs at a younger age; it is predominant in females, and is more often associated with unilateral ocular lesions. Retinal screening of patients with suprasellar PNET and other atypically located PNETs may disclose more cases of sellar ‘trilateral retinoblastoma’ and hereditary retinoblastomas. This will have implications on genetic counseling as siblings harboring the disease may be diagnosed and treated at an earlier stage.

show abstract

“…This is a --50 kD protein which has been isolated from human retina [13] and localized immunohistochemically to the photoreceptor layer [14]. It has also been identified by immunohistochemistry in human pineal cells [14,15], pineal parenchymal tumors [15,16], retinoblastomas [17] and medulloblastomas [18]. In the present tumor, like in these neoplasms, demonstration of retinal S-antigen was interpreted as an indication of photoreceptor differentiation.…”

Section: Discussionmentioning

confidence: 68%

Primitive pineal tumor with retinoblastomatous and retinal/ciliary epithelial differentiation: an immunohistochemical study

1990

View full text Add to dashboard Cite

A one year old boy was found to have a large tumor encompassing the pineal region and extending towards the third and lateral ventricles and quadrigeminal plate. The tumor was composed mostly of small, undifferentiated cells. Some small cells were arranged in Flexner-Wintersteiner rosettes and a few displayed fleurettes. The tumor contained immature cartilage and skeletal muscle and numerous clusters of pigmented epithelial-like cells which, histologically, resembled those found in melanotic neuroectodermal tumors of infancy (retinal anlage tumors) and retinal or ciliary epithelium. Immunologic stains demonstrated neurofilaments synaptophysin and retinal S-antigen in some of the small cells and transthyretin in some of the epithelial-like cells. The findings indicate that certain primary pineal parenchymal tumors have features in common with tumors of the ocular medullary epithelium.

show abstract

S-Antigen immunoreactivity in human pineal glands and pineal parenchymal tumors. A monoclonal antibody study

Cited by 68 publications

References 8 publications

The anatomy and innervation of the mammalian pineal gland

The anatomy and innervation of the mammalian pineal gland

Association of a Suprasellar Mass and Intraocular Retinoblastoma: A Variant of Pineal Trilateral Retinoblastoma?

Primitive pineal tumor with retinoblastomatous and retinal/ciliary epithelial differentiation: an immunohistochemical study

Contact Info

Product

Resources

About