S-(+)-Linalool from Lippia alba: sedative and anesthetic for silver catfish (Rhamdia quelen)

Heldwein, Clarissa G.; Silva, Lenise de L.; Gai, Eduarda Z; Roman, Cassiela; Parodi, Thaylise Vey; Bürger, Marilise Escobar; Baldisserotto, Bernardo; Flores, Érico M.M.; Heinzmann, Berta Maria

doi:10.1111/vaa.12146

Cited by 78 publications

(86 citation statements)

References 31 publications

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“…Physiological effects of the EO of L. alba cultivated in southern Brazil as anesthetic and sedative for silver catfish, Rhamdia quelen, was verified by many authors (Cunha et al, 2010;Heldwein et al, 2014;Toni et al, 2014;Salbego et al, 2014), but only the linalool chemotype. Therefore, it is of interest to investigate the anesthetic and physiological effects of EO obtained from other chemotypes of L. alba.…”

Section: Introductionmentioning

confidence: 99%

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Physiological responses of Rhamdia quelen (Siluriformes: Heptapteridae) to anesthesia with essential oils from two different chemotypes of Lippia alba

et al. 2017

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The aim of this study was to evaluate if Lippia alba has different chemotypes according to the chemical composition of the essential oil (EO) considering collection site, and if the EO may have different effects on blood and plasma parameters in silver catfish, Rhamdia quelen, during and immediately after anesthesia. The citral (EO-C) and linalool (EO-L) chemotypes were identified, and both presented similar anesthetic effects for silver catfish. Fish were exposed to two concentrations of each EO, which induced slow and fast anesthesia (100 and 300 µL L -1 , respectively). Blood ions did not change at any time of anesthesia induction and recovery and, therefore, the electrolyte balance was not altered. Blood gases oscillated through all exposure and recovery times, but there was an increase in pO 2 after 10 min recovery in fish anesthetized with EO-C. Glucose increased in fish exposed to both EOs when compared with the control group. Overall, exposure to both EOs (except 100 µL L -1 EO-L at most times) reduced plasma cortisol levels compared to the control and/or ethanol groups. However, as plasma creatinine levels in fish anesthetized with EO-C were higher than control fish, the use of EO-L is preferable.Keywords: Blood gas, Cortisol, Glucose, Plasma ions, Silver Catfish.O objetivo deste estudo foi avaliar se Lippia alba apresenta diferentes quimiotipos de acordo com a composição química do óleo essencial (OE), considerando local de coleta e se o OE causa diferentes efeitos nos parâmetros sanguíneos e plasmáticos em jundiá, Rhamdia quelen, durante e imediatamente após a anestesia. Os quimiotipos citral (OE-C) e linalol (OE-L) foram identificados e ambos apresentaram efeito anestésico semelhante para jundiá. Os peixes foram expostos a duas concentrações de cada OE, que induziram anestesia lenta e rápida (100 e 300 mL L -1 , respectivamente). Íons sanguíneos não se alteraram em nenhum tempo e consequentemente, o equilíbrio eletrolítico não foi alterado. Os gases sanguíneos oscilaram durante todo tempo de exposição e recuperação, mas houve aumento na pO 2 após 10 min de recuperação em peixes anestesiados com OE-C. Níveis sanguíneos de glicose aumentaram nos peixes expostos a ambos OEs quando comparados com o grupo controle. De um modo geral, a exposição a ambos OEs (exceto 100 µL L -1 OE-L na maioria dos tempos) reduziu o cortisol plasmático comparado aos grupos controle e etanol. No entanto, como os níveis de creatinina plasmática em peixes anestesiados com OE-C foram maiores que nos peixes controle, é preferível o uso do OE-L.

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Section: Introductionmentioning

confidence: 99%

“…The EO of Lippia alba has been highlighted in the last decade through studies reporting its potential as antioxidant, anesthetic and sedative for fish (Cunha et al, 2010;Becker et al, 2012;Heldwein et al, 2014;Toni et al, 2014;Hohlenwerger et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Physiological responses of Rhamdia quelen (Siluriformes: Heptapteridae) to anesthesia with essential oils from two different chemotypes of Lippia alba

et al. 2017

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“…Almost all anesthetic substances used in shellfish are synthetic products such as benzocaine, MS-222 and 2-phenoxyethanol, and the minority are plant extractives (GARR et al, 2012). Essential oils (EOs) of Lippia alba and Aloysia triphylla (PARODI et al, 2012), for example, and isolated substances such as eugenol (GOMES et al, 2011;PARODI et al, 2012) and linalool (HELDWEIN et al, 2014) are effective to anesthetize fish and shrimps. Thus, we can assume that EOs may also be effective in mollusks.…”

Section: Introductionmentioning

confidence: 99%

Relaxing effect of eugenol and essential oils in Pomacea canaliculata

et al. 2017

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This study evaluated the potential relaxing and/or molluscicidal effects of eugenol and essential oils of Origanum majorana, Ocimum americanum, Hesperozygis ringens, and Piper gaudichaudianum in the gastropod Pomacea canaliculata. Compounds were tested at concentrations of 100, 250, 500, and 750µL L-1 to evaluate the relaxing effects. In the second experiment, animals were exposed to 10, 25, and 50µL L-1 of essential oils of H. ringens and P. gaudichaudianum for a period of 24h for the evaluation of molluscicidal effects. Eugenol and essential oils of O. majorana and O. americanum showed relaxing effects at ≥250µL L-1, but the essential oils of H. ringens and P. gaudichaudianum did not promote relaxing or molluscicidal effects within the times and concentrations studied. Therefore, only eugenol and the essential oils of O. majorana and O. americanum can be used for relaxation purposes in P. canaliculata.

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“…Despite the difference in induction and recovery times between the EOs, both natural products triggered anesthetic action, which may be correlated to the presence of specific chemical compounds. In the case of EOC, linalool is the main compound, which has been reported as sedative and anesthetic for R. quelen (Heldwein et al, 2014). EO of linalool chemotype L. alba has similarly induced anesthesia in R. quelen (Cunha et al, 2010;Toni et al, 2014) and in L.vannamei .…”

Section: Discussionmentioning

confidence: 99%

Essential oils of Cunila galioides and Origanum majorana as anesthetics for Rhamdia quelen: efficacy and effects on ventilation and ionoregulation

et al. 2017

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This study evaluated anesthetic efficacy and possible effects of the essential oils (EOs) of Cunila galioides (EOC) and Origanum majorana (EOO) on ventilatory rate (VR) and ionoregulation in Rhamdia quelen. In the anesthesia assessments, 50, 100, 200 and 300 μL L -1 EOC and 50, 100, 200, 300, 400 and 500 μL L -1 EOO were tested, and time for induction to sedation and anesthesia stages, as well as recovery, were taken. A second trial employed lower concentrations of both EOs, 10, 25, 50 and 100 μL L . There was no significant difference between control and EO-treated groups regarding VR, but all fish subjected to 100 µL L -1 EOC died within 2 h of exposure. Overall, ionic loss declined in the presence of the EOs. The EOC at 200 -300 μL L -1 and EOO at 400 -500 μL L -1 present the potential to promote fast anesthesia in R. quelen.

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S-(+)-Linalool from Lippia alba: sedative and anesthetic for silver catfish (Rhamdia quelen)

Cited by 78 publications

References 31 publications

Physiological responses of Rhamdia quelen (Siluriformes: Heptapteridae) to anesthesia with essential oils from two different chemotypes of Lippia alba

Physiological responses of Rhamdia quelen (Siluriformes: Heptapteridae) to anesthesia with essential oils from two different chemotypes of Lippia alba

Relaxing effect of eugenol and essential oils in Pomacea canaliculata

Essential oils of Cunila galioides and Origanum majorana as anesthetics for Rhamdia quelen: efficacy and effects on ventilation and ionoregulation

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