S-protected thiolated hydroxyethyl cellulose (HEC): Novel mucoadhesive excipient with improved stability

Leonavičiūtė, Gintarė; Bonengel, Sonja; Mahmood, Arshad; Idrees, Muneeb Ahmad; Bernkop‐Schnürch, Andreas

doi:10.1016/j.carbpol.2016.02.075

Cited by 17 publications

(10 citation statements)

References 29 publications

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“…As for the FT-IR spectra of HEC, the peak at 3423 cm –1 is resulted from the stretching vibration of the −OH group. Compared with HEC, one stronger stretching vibration absorption peak at 1726 cm –1 is exhibited in the FT-IR spectrum of OHEC, which is resulted from the characteristic absorption peak of CO bond in the aldehyde group, indicating that the oxidation reaction has arisen. For OHCM-50 hydrogel, it can be observed that the peak at 1638 cm –1 is attributed to the angle vibration of H–O–H due to hydrogen bonds among the hydrogel .…”

Section: Results and Discussionmentioning

confidence: 99%

Smart pH-Sensitive Hydrogel Based on the Pineapple Peel-Oxidized Hydroxyethyl Cellulose and the Hericium erinaceus Residue Carboxymethyl Chitosan for Use in Drug Delivery

et al. 2021

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Pineapple and hericium erinaceus (HE) produce a lot of residues in the process of food processing. These processed residues are good potential derivative precursors. In this investigation, a simple and non-toxic method was developed to prepare one new composite hydrogel by the Schiff base reaction between the aldehyde group of oxidized hydroxyethyl cellulose (OHEC) from processed pineapple peel residue and the amino group of carboxymethyl chitosan (CMCS) from processed HE residue. Subsequently, a series of experiments toward these new hydrogel polymers including structure characterization and performances were applied. The resultant hydrogel polymers were characterized by Fourier transform infrared spectroscopy and scanning electron microscopy and confirmed with thermogravimetry. It was observed that the modification of cellulose and chitin was adequate, and the synthesis of OHEC/CMCS hydrogel polymers was successful. The gelation time experiments indicated that the shortest gel time was 33 s at a mass ratio of 4:6 (OHEC-70:CMCS). The hydrogel showed good swelling properties. The maximum swelling rate reached 11.58 g/g, and the swelling rate decreased with the increase of the oxidation degree of OHEC. The drug delivery applications of the prepared hydrogel were evaluated with bovine serum albumin (BSA) as a model drug releasing in vitro. It was discovered that the BSA release from the hydrogel was pH sensitive under simulated gastrointestinal conditions. All of these attributes indicate that the novel prepared hydrogel polymers have the potential as good carriers for oral delivery of protein-type drugs.

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Section: Results and Discussionmentioning

confidence: 99%

Smart pH-Sensitive Hydrogel Based on the Pineapple Peel-Oxidized Hydroxyethyl Cellulose and the Hericium erinaceus Residue Carboxymethyl Chitosan for Use in Drug Delivery

et al. 2021

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“…The Fourier transform infrared (FTIR) spectra of CMCS, HPC, OHPC, Fe 3 O 4 , and the nanoparticle-containing hydrogel (NP-hydrogel) are shown in Figure A. Compared with the FTIR spectrum of HPC, that of OHPC showed a new absorption peak at 1730 cm –1 , which belongs to the characteristic absorption peak of the aldehyde group (CO), indicating successful oxidation of the hydroxypropyl groups . In addition, the strong absorption peaks at 510 cm –1 in NP-hydrogels and Fe 3 O 4 nanoparticles are characteristic peaks of −Fe–O.…”

Section: Resultsmentioning

confidence: 99%

“…Compared with the FTIR spectrum of HPC, that of OHPC showed a new absorption peak at 1730 cm −1 , which belongs to the characteristic absorption peak of the aldehyde group (C�O), indicating successful oxidation of the hydroxypropyl groups. 41 In addition, the strong absorption peaks at 510 cm −1 in NP-hydrogels and Fe 3 O 4 nanoparticles are characteristic peaks of −Fe−O. The X-ray diffraction (XRD) spectra of the above compounds are shown in Figure 1B.…”

Section: ■ Introductionmentioning

confidence: 98%

Design of an Injectable Magnetic Hydrogel Based on the Tumor Microenvironment for Multimodal Synergistic Cancer Therapy

Hai

Cheng

et al. 2023

Biomacromolecules

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Conventional tumor chemotherapy is limited by its low therapeutic efficacy and side effects, which severely hold back its further application. Drug delivery systems (DDSs) based on nanomaterials have attracted wide interest in cancer treatment; especially, the system can realize efficient synergistic therapies. Here, we designed a smart hydrogel drug delivery system with multiple responses to enhance the tumor treatment effect. By cross-linking oxidized hydroxypropyl cellulose with carboxymethyl chitosan, an injectable hydrogel was obtained, into which artesunate (ART), ferroferric oxide (Fe 3 O 4 ) nanoparticles, and black phosphorus nanosheets (BPs) were preloaded. This DDS has multiple functions including magnetic targeting, pH sensitivity, chemodynamic therapy, and photothermal response. This nanoparticle-composited hydrogel not only preserved excellent rheological properties but also allowed for an accurate stable drug release at tumor sites and synergistic effects of multiple therapies. The in vitro and in vivo experiments revealed that this DDS could efficiently eliminate the HepG2 tumor with good biocompatibility. Taken together, this study clarifies the possible antitumor mechanism of this ART-loaded nanoparticle-composited hydrogel and provides a new strategy for synergistic photothermal− chemo−chemodynamic therapy.

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“…Thiolation of polymer backbones derived from naturally occurring biopolymers, like hyaluronic acid [ 52 ], chitosan [ 53 , 54 ], alginate [ 55 ], gellan gum [ 56 , 57 ], starch [ 58 ], glycogen [ 59 ], cellulose [ 60 , 61 ], arabinoxylan [ 62 ], xanthan gum [ 63 , 64 ], and cyclodextrins [ 65 , 66 , 67 ] have been studied as mucoadhesive materials. The mucoadhesive properties of thiolated synthetic polymers have been studied, also.…”

Section: Reaction Types and Applicationsmentioning

confidence: 99%

Thiol- and Disulfide-Based Stimulus-Responsive Soft Materials and Self-Assembling Systems

Beaupre

Weiss

2021

Molecules

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S-protected thiolated hydroxyethyl cellulose (HEC): Novel mucoadhesive excipient with improved stability

Cited by 17 publications

References 29 publications

Smart pH-Sensitive Hydrogel Based on the Pineapple Peel-Oxidized Hydroxyethyl Cellulose and the Hericium erinaceus Residue Carboxymethyl Chitosan for Use in Drug Delivery

Smart pH-Sensitive Hydrogel Based on the Pineapple Peel-Oxidized Hydroxyethyl Cellulose and the Hericium erinaceus Residue Carboxymethyl Chitosan for Use in Drug Delivery

Design of an Injectable Magnetic Hydrogel Based on the Tumor Microenvironment for Multimodal Synergistic Cancer Therapy

Thiol- and Disulfide-Based Stimulus-Responsive Soft Materials and Self-Assembling Systems

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