S100B in the cerebrospinal fluid—A marker for glial damage in the rabbit model of pneumococcal meningitis

Schmidt, Holger; Gerber, Joachim; Stuertz, Kristin; Djukic, Marija; Bunkowski, Stephanie; Fischer, Falko R.; Otto, Markus; Nau, Roland

doi:10.1016/j.neulet.2010.03.059

Cited by 13 publications

(10 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In bacterial meningitis of rabbit, S100B is significantly increased in CSF, which is related to CNS inflammation and astrocyte damage (Schmidt et al, 2010). Case reports on humans indicate elevated S100B in the CSF of adult and infants during bacterial infection.…”

Section: Discussionmentioning

confidence: 94%

Matrix metalloproteinase-9 leads to blood–brain barrier leakage in mice with eosinophilic meningoencephalitis caused by Angiostrongylus cantonensis

Chiu¹,

Lai²

2014

Acta Tropica

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 94%

Matrix metalloproteinase-9 leads to blood–brain barrier leakage in mice with eosinophilic meningoencephalitis caused by Angiostrongylus cantonensis

Chiu¹,

Lai²

2014

Acta Tropica

View full text Add to dashboard Cite

“…The physiological release of S100β exerts neurotrophic effects in the brain [94] and intense S100β expression also is observed within white matter tracts, including the corpus callosum [108]. CSF levels of S100β correlated with white matter injury after pneumococcal meningitis [109] and endotoxin-induced periventricular white matter injury in preterm fetal sheep was associated with higher S100β levels [81]. Reduced tissue expression of S100β was observed in the corpus callosum of schizophrenia patients [110] whereas increased serum levels of S100β directly correlated with white matter injury in schizophrenic patients [111] and in asphyxiated preterm babies [112].…”

Section: Damage Associated Molecular Patterns (Damps): Mediators Omentioning

confidence: 99%

White matter damage after traumatic brain injury: A role for damage associated molecular patterns

Braun

Vaibhav

Saad

et al. 2017

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Diseas

View full text Add to dashboard Cite

Traumatic brain injury (TBI) is a leading cause of mortality and long-term morbidity worldwide. Despite decades of pre-clinical investigation, therapeutic strategies focused on acute neuroprotection failed to improve TBI outcomes. This lack of translational success has necessitated a reassessment of the optimal targets for intervention, including a heightened focus on secondary injury mechanisms. Chronic immune activation correlates with progressive neurodegeneration for decades after TBI; however, significant challenges remain in functionally and mechanistically defining immune activation after TBI. In this review, we explore the burgeoning evidence implicating the acute release of damage associated molecular patterns (DAMPs), such as adenosine 5′-triphosphate (ATP), high mobility group box protein 1 (HMGB1), S100 proteins, and hyaluronic acid in the initiation of progressive neurological injury, including white matter loss after TBI. The role that pattern recognition receptors, including toll-like receptor and purinergic receptors, play in progressive neurological injury after TBI is detailed. Finally, we provide support for the notion that resident and infiltrating macrophages are critical cellular targets linking acute DAMP release with adaptive immune responses and chronic injury after TBI. The therapeutic potential of targeting DAMPs and barriers to clinical translational, in the context of TBI patient management, are discussed.

show abstract

“…У пациентов с бактериальным менингитом и менингоэнцефалитом повышены сывороточные концентрации NSE и S100B, отражающие нейрональную деструкцию и глиальное повреждение, соответственно [22,23]. Повы шение концентрации этих маркеров было также выявлено в экспериментальном исследовании у кроликов в течение 12 ч после развития пневмококкового менингита.…”

Section: новые методы диагностики бактериального менингитаunclassified

Diagnosis and current treatment of pneumococcal meningitis

Агаркова¹,

Покровский²,

Корокина³

et al. 2019

CPT

View full text Add to dashboard Cite

S100B in the cerebrospinal fluid—A marker for glial damage in the rabbit model of pneumococcal meningitis

Cited by 13 publications

References 31 publications

Matrix metalloproteinase-9 leads to blood–brain barrier leakage in mice with eosinophilic meningoencephalitis caused by Angiostrongylus cantonensis

Matrix metalloproteinase-9 leads to blood–brain barrier leakage in mice with eosinophilic meningoencephalitis caused by Angiostrongylus cantonensis

White matter damage after traumatic brain injury: A role for damage associated molecular patterns

Diagnosis and current treatment of pneumococcal meningitis

Contact Info

Product

Resources

About