S100PBP is regulated by mutated KRAS and plays a tumour suppressor role in pancreatic cancer

QN-302 demonstrates opposing effects between i-motif and G-quadruplex DNA structures in the promoter of the S100P gene

“…This is particularly important given the recent analysis of TCGA PanCancer Atlas PDAC datasets that indicate poor prognosis in patients with high S100P expression. 34 QN-302 exhibits exceptional combined synergistic effects compared to many other G-quadruplex and i-motif interacting compounds. Overall, this work further emphasises the importance of considering these two alternative DNA structures as one dynamic system and as one target.…”