S2962 Crypto Can Be Confusing: Cryptogenic Cirrhosis Occurring in Isolated Heterozygous Alpha1 Antitrypsin Deficiency

Abstract

heterozygous individuals. Individuals arent routinely screened for A1AT, however a biopsy may aide in arriving to the correct diagnosis. Early detection, allows for early transplant evaluation, genetic counseling and education.[2962] Figure 1. The biopsy shows a core liver biopsy with overall preserved architecture and few portal tracts seen. PAS with diastase highlights a very patchy distribution of bright, magenta-colored globules in mainly periportal hepatocytes (black arrows).