S79 Cough Prevalence And Frequency In Pulmonary Tuberculosis

Turner, RD; Repossi, AC; Matos, Sérgio; Birring, SS; Bothamley, GH

doi:10.1136/thoraxjnl-2014-206260.85

Cited by 5 publications

(5 citation statements)

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“…The main limitation of this study was the short duration of (overnight) cough recordings, owing to the technology available at the time. Cough in other diseases is more prevalent during the daytime [40], and this also seems to be the case for tuberculosis [41].…”

Section: Temporal Patterns Of Coughmentioning

confidence: 88%

Cough and the Transmission of Tuberculosis

Turner¹,

Bothamley²

2014

The Journal of Infectious Diseases

117

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Cough is a predominant feature of respiratory infection and, in tuberculosis, is of prime importance for transmitting infection. Tuberculosis is transmitted by the air, yet the process by which bacilli are aerosolized has received little attention. Features of cough may account for differences in transmission rates from source cases of pulmonary disease. We review the literature on the mechanisms and characteristics of cough in tuberculosis in the context of the dissemination of infection. Coughing is probably more important than other respiratory maneuvers, and characteristics of mucus may have an important role but data are scarce. Direct mechanisms of cough in tuberculosis are unknown, as are temporal and other patterns that correlate with the release of viable airborne bacilli. Other than antituberculous chemotherapy and masks, there are few methods of modulating cough in tuberculosis. This is an increasingly important area for research.

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Section: Temporal Patterns Of Coughmentioning

confidence: 88%

Cough and the Transmission of Tuberculosis

Turner¹,

Bothamley²

2014

The Journal of Infectious Diseases

117

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“… 19 As reported in abstract form, the objective acoustic Leicester Cough Monitor (LCM) has been used to evaluate 24 h cough recordings in patients with pulmonary TB before starting treatment, showing that cough frequency is reduced at night. 59 This further justifies re-evaluation of Loudon's overnight study.…”

Section: Discussionmentioning

confidence: 90%

Protocol for studying cough frequency in people with pulmonary tuberculosis

Proaño

Bravard²,

Tracey

et al. 2016

BMJ Open

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IntroductionCough is a key symptom of tuberculosis (TB) as well as the main cause of transmission. However, a recent literature review found that cough frequency (number of coughs per hour) in patients with TB has only been studied once, in 1969. The main aim of this study is to describe cough frequency patterns before and after the start of TB treatment and to determine baseline factors that affect cough frequency in these patients. Secondarily, we will evaluate the correlation between cough frequency and TB microbiological resolution.MethodsThis study will select participants with culture confirmed TB from 2 tertiary hospitals in Lima, Peru. We estimated that a sample size of 107 patients was sufficient to detect clinically significant changes in cough frequency. Participants will initially be evaluated through questionnaires, radiology, microscopic observation drug susceptibility broth TB-culture, auramine smear microscopy and cough recordings. This cohort will be followed for the initial 60 days of anti-TB treatment, and throughout the study several microbiological samples as well as 24 h recordings will be collected. We will describe the variability of cough episodes and determine its association with baseline laboratory parameters of pulmonary TB. In addition, we will analyse the reduction of cough frequency in predicting TB cure, adjusted for potential confounders.Ethics and disseminationEthical approval has been obtained from the ethics committees at each participating hospital in Lima, Peru, Asociación Benéfica PRISMA in Lima, Peru, the Universidad Peruana Cayetano Heredia in Lima, Peru and Johns Hopkins University in Baltimore, USA. We aim to publish and disseminate our findings in peer-reviewed journals. We also expect to create and maintain an online repository for TB cough sounds as well as the statistical analysis employed.

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“…The LCM and the CayeCoM have been used to investigate cough among people with pulmonary TB. Turner et al used the LCM as part of a cross-sectional survey of cough frequency among people with TB and their contacts 32 . Williams et al used the LCM to correlate exhaled M. tuberculosis with cough frequency 15 .…”

Section: Advances In Acoustics For Objective Cough Monitoringmentioning

confidence: 99%

Making cough count in tuberculosis care

Zimmer

Ugarte-Gil

Pathri³

et al. 2022

Commun Med

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Cough assessment is central to the clinical management of respiratory diseases, including tuberculosis (TB), but strategies to objectively and unobtrusively measure cough are lacking. Acoustic epidemiology is an emerging field that uses technology to detect cough sounds and analyze cough patterns to improve health outcomes among people with respiratory conditions linked to cough. This field is increasingly exploring the potential of artificial intelligence (AI) for more advanced applications, such as analyzing cough sounds as a biomarker for disease screening. While much of the data are preliminary, objective cough assessment could potentially transform disease control programs, including TB, and support individual patient management. Here, we present an overview of recent advances in this field and describe how cough assessment, if validated, could support public health programs at various stages of the TB care cascade.

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S79 Cough Prevalence And Frequency In Pulmonary Tuberculosis

Cited by 5 publications

References 1 publication

Cough and the Transmission of Tuberculosis

Cough and the Transmission of Tuberculosis

Protocol for studying cough frequency in people with pulmonary tuberculosis

Making cough count in tuberculosis care

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