Sa1110 ENDOSCOPIC AND HISTOLOGIC INFLAMMATION IN THE PROXIMAL COLON IS A RISK FACTOR FOR THE DEVELOPMENT OF DYSPLASIA IN IBD PATIENTS WITH PSC

Jamil, Omar; Deng, Zifeng; Shaw, Dustin G.; DiNardi, Nicholas; Fillman, Natalie; Khanna, Shivani; Cleveland, Noa Krugliak; Sakuraba, Atsushi; Weber, Christopher; Cohen, Russell D.; Dalal, Sushila; Jabrì, Bana; Rubin, David T.; Pekow, Joel

doi:10.1016/s0016-5085(20)31384-6

Cited by 2 publications

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“…However, this recommendation has not been universally confirmed, as some UC patients may exhibit higher inflammatory activity in the ascending colon. In such cases, total colonoscopy becomes the most appropriate endoscopic examination to assess inflammation in UC patients[ 13 , 14 ]. Although sigmoidoscopy is limited to evaluating inflammatory activity from the rectum to the descending colon, it is essential to recognize some benefits of this procedure.…”

Section: To the Editormentioning

confidence: 99%

Are we ready to use new endoscopic scores for ulcerative colitis?

Quera,

Núñez F

2024

World J Gastroenterol

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For ulcerative colitis (UC), the variability in inflammatory activity along the colon poses a challenge in management. The focus on achieving endoscopic healing in UC is evident, where the UC Endoscopic Index of Severity and Mayo Endoscopic Subscore are commonly used for evaluation. However, these indices primarily consider the most severely affected region. Liu et al recent study validates the Toronto Inflammatory Bowel Disease Global Endoscopic Reporting (TIGER) score offering a comprehensive assessment of inflammatory activity across diverse segments of the colon and rectum and a reliable index correlating strongly with UC Endoscopic Index of Severity and moderately with Mayo Endoscopic Subscore (MES). Despite recommendation, certain aspects warrant further investigation. Fecal calprotectin, an intermediate target, correlates with TIGER and should be explored. Determining TIGER scores defining endoscopic remission and response, evaluating agreement with histological activity, and assessing inter-endoscopist agreement for TIGER require scrutiny. Exploring the correlation between TIGER and intestinal ultrasound, akin to MES, adds value.

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Section: To the Editormentioning

confidence: 99%