Sa1156 Systematic Review and Meta-Analysis of the Prognostic Significance of Circumferential Resection Margin Involvement, As Defined by CAP and Rcp Criteria, on Survival in Patients With Operable Esophageal Cancer

Chan, David; Karran, Alex; Reid, Tom; Blake, Paul A.; Lewis, Wyn G.

doi:10.1016/s0016-5085(13)60762-3

Cited by 5 publications

(5 citation statements)

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“…Circumferential margin status is prognostically important but this may be affected by the criteria used to define a positive margin [29,30]. Almost all (96%) of our R1 resections were related to CRM involvement, which at 38% overall, is in line with other published series after neo-adjuvant chemotherapy using the RCP definition [31].…”

Section: Discussionsupporting

confidence: 83%

Factors associated with early recurrence and death after esophagectomy for cancer

Davies

Pillai

Sinha

et al. 2013

Journal of Surgical Oncology

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Section: Discussionsupporting

confidence: 83%

Factors associated with early recurrence and death after esophagectomy for cancer

Davies

Pillai

Sinha

et al. 2013

Journal of Surgical Oncology

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“…In patients with adenocarcinoma of the esophagogastric junction (AEG), surgeons aim towards complete tumor resection (R0). Microscopic tumor involvement of a resection margin (R1) has been shown to adversely affect prognosis [1][2][3][4]. Reports for the prevalence of R1-resections in AEG range from 10 to 38% [2,5,6].…”

Section: Introductionmentioning

confidence: 99%

What to do after R1-resection of adenocarcinomas of the esophagogastric junction?

et al. 2016

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The association of R1-resections with poor tumor characteristics allows for identification of patients at risk for R1-resection. As in R0-resections, tumor recurrence in R1-resections is mainly systemic, not local. The potential benefit of additive local postoperative therapies in R1-resected patients must be balanced against overall prognosis and therapy-specific morbidity and mortality. J. Surg. Oncol. 2016;114:428-433. © 2016 Wiley Periodicals, Inc.

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“…Complete R0 resection of GEJ tumours is key to achieving good survival outcomes. Systematic review and meta-analysis of fourteen studies involving 2433 patients with oesophageal cancer who had undergone oesophagectomy showed that circumferential resection margin (CRM) involvement was associated with significantly higher 5-year mortality rate (OR 2.05, 95%CI: 1.41-2.99; P < 0.001) [45] .…”

Section: Surgical Management Of Gej Tumoursmentioning

confidence: 99%

Overview of gastroesophageal junction cancers

Oo¹,

Ahmed²

2019

MIS

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Oesophageal and gastroesophageal junction (GEJ) malignancy is the fastest growing cancer in the Western population. This together with the deadly nature of the disease has attracted increased attention from doctors and researchers alike. The increasing incidence has been primarily attributed to the increase in rates of obesity that in turn causes increased gastroesophageal reflux disease leading to Barrett's oesophagus and eventually adenocarcinoma of the oesophagus especially at the GEJ. We discuss the epidemiology, risk factors and the management of GEJ tumours. DEFINITIONThe definition of GEJ cancers has been an area of controversy and disagreement and have in the past been considered either a gastric or oesophageal cancer as they lie in between the two. GEJ tumours also DECLARATIONS Authors' contributionsOo AM and Ahmed S contributed equally to literature search and writing of manuscript.

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Sa1156 Systematic Review and Meta-Analysis of the Prognostic Significance of Circumferential Resection Margin Involvement, As Defined by CAP and Rcp Criteria, on Survival in Patients With Operable Esophageal Cancer

Cited by 5 publications

References 0 publications

Factors associated with early recurrence and death after esophagectomy for cancer

Factors associated with early recurrence and death after esophagectomy for cancer

What to do after R1-resection of adenocarcinomas of the esophagogastric junction?

Overview of gastroesophageal junction cancers

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