Sa1182 Quantifying Esophagogastric Junction (EGJ) Relaxation With a 3D-High-Resolution Manometry (HRM) Device: Comparison With Standard HRM and Among Novel Analysis Paradigms

Nicodème, Frédéric; Xiao, Yinglian; Ruigh, Annemijn de; Escobar, Gabriela I.; Lin, Zhiyue; Kahrilas, Peter J.; Pandolfino, John E.

doi:10.1016/s0016-5085(12)60889-0

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“…Three‐dimensional high‐resolution manometry (3D‐HRM) is a recently developed, now commercial tool that, unlike standard HRM catheters, preserves and yields individual directional pressures . The improvement in the number and positioning of the 3D sensors has made 3D‐HRM significantly more valid and reliable for simultaneously evaluating multiple adjacent locations in comparison to previously constructed catheters.…”

Section: Introductionmentioning

confidence: 99%

“…The improvement in the number and positioning of the 3D sensors has made 3D‐HRM significantly more valid and reliable for simultaneously evaluating multiple adjacent locations in comparison to previously constructed catheters. Thus far, 3D‐HRM has proven to be useful in evaluating pressure in other areas of the alimentary canal, including the esophagogastric junction and anal canal, and it has most recently been used to identify asymmetry in the UES region during swallowing and nonswallowing tasks . Assessment of the more rostral pharynx with this more robust technology, however, has not yet been reported.…”

Section: Introductionmentioning

confidence: 99%

“…14 Three-dimensional high-resolution manometry (3D-HRM) is a recently developed, now commercial tool that, unlike standard HRM catheters, preserves and yields individual directional pressures. 15 The improvement in the number and positioning of the 3D sensors has made 3D-HRM significantly more valid and reliable for simultaneously evaluating multiple adjacent locations in comparison to previously constructed catheters. Thus far, 3D-HRM has proven to be useful in evaluating pressure in other areas of the alimentary canal, including the esophagogastric junction [15][16][17] and anal canal, 18 and it has most recently been used to identify asymmetry in the UES region during swallowing and nonswallowing tasks.…”

Section: Introductionmentioning

confidence: 99%

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Pharyngeal swallowing pressures in the base‐of‐tongue and hypopharynx regions identified with three‐dimensional manometry

2017

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Objectives This study aims to use three-dimensional (3D) high-resolution manometry to identify circumferential pressure patterns generated within the asymmetrical base-of-tongue and hypopharynx regions of the pharynx during deglutition. Study Design Case series. Methods Radial pressures in the regions of interest were evaluated during swallowing events in 12 healthy subjects using 3D high-resolution manometry. Results Repeated measures analysis of variance revealed asymmetrical pharyngeal clearance pressures in the base-of-tongue and hypopharynx regions during swallowing. A significant main effect of direction on pressure was found at the time point of average maximum pressure (P < 0.001) and for pressure integral (P < 0.001), with pressure primarily generated from the posterior direction. An interaction was noted between direction and location when comparing maximum directional pressures, regardless of time (P =0.045), highlighting the differences in anterior pressure production between regions. In contrast to the high posterior pressures produced in the base-of-tongue region, an anteroposterior dominant pressure pattern was observed in the hypopharynx. Pressure waveform complexity in the hypopharynx also is likely attributed to activity in the anterior and posterior directions. Symmetrical pressure generation was observed during intrabolus flow within the hypopharynx. Conclusion This study shows that pressure is asymmetrically generated in the base-of-tongue and hypopharynx regions during swallowing of a 10-mL bolus, reflecting the complex anatomy within the pharynx. Understanding of these complex pressure patterns aids in the interpretation of high-resolution manometry and can help guide further study in the clinical assessment and treatment of pharyngeal pathology.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%