Sa1952a The First Steps in the Development of Gastric Cancer Riskometry: The Siberian Retrospective Case-Control Study. Novosibirsk State Medical University, Russian Federation

Курилович, С. А.; Белковец, А. В.; Reshetnikov, O V; Опенко, Т. Г.; Ragino, Yulia

doi:10.1016/s0016-5085(14)61222-1

Cited by 5 publications

(5 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This four-biomarker panel is based on stomach physiology and includes three atrophy markers in various topographic areas (pepsinogen I and pepsinogen II for the corpus and gastrin-17 for antrum), and immunoglobulin antibodies against H. pylori . It is emphasized in Europe that GastroPanel is not a gastric cancer detection test but rather a screening tool for people at risk of gastric cancer (Kurilovich et al ., 2016).…”

Section: Introductionmentioning

confidence: 99%

Assessing the utility of pepsinogens and gastrin-17 in gastric cancer detection

Gasenko¹,

Bogdanova²,

Sjomina

et al. 2023

European Journal of Cancer Prevention

View full text Add to dashboard Cite

ObjectivesThe aim of the study was to determine the proportion of gastric cancer patients with decreased levels of pepsinogen and gastrin-17 in plasma, with the goal of providing indirect evidence of the sensitivity of these biomarkers when applied in a cancer screening setting. MethodsThe levels of pepsinogens I and II, gastrin-17, and Helicobacter pylori immunoglobulin antibodies in plasma samples of gastric cancer patients were evaluated using the GastroPanel test system (Biohit Oyj, Helsinki, Finland). A decreased level of the pepsinogen I/ II ratio was defined as less than three, while a decrease in gastrin-17 was defined as less than 1 pmol/L. Univariate analysis using non-parametric tests was used to investigate differences between normal and low concentrations of biomarkers. ResultsIn total, 481 plasma samples from patients (59.9% male) with a median age of 64 years (ranging from 27 to 88 years) were analyzed. Out of the 400 cases of gastric cancer (83.2% of the total), 182 were categorized as the intestinal type, 141 as the diffuse type, 60 as the mixed type, and 17 as indeterminate according to the Lauren classification system. The H. pylori immunoglobulin test was positive in 74.0% of the patients. Pepsinogen I/ II ratio was decreased in 32.4% (36.8% of the intestinal type); gastrin-17 in 12.3% (10.1% of the antral region) of all cases. ConclusionThe majority of gastric cancer patients had normal levels of pepsinogen and gastrin-17, suggesting that these biomarkers have limited application as screening tools in the Caucasian population. European

show abstract

Section: Introductionmentioning

confidence: 99%

Assessing the utility of pepsinogens and gastrin-17 in gastric cancer detection

Gasenko¹,

Bogdanova²,

Sjomina

et al. 2023

European Journal of Cancer Prevention

View full text Add to dashboard Cite

show abstract

“…38 In a case-control study from Siberia involving adults aged 45-69 years old (n = 9360), among the controls the percentage of H. pylori infection was 90.1%, but that of gastric atrophy was 16.2%. 39 Kazakhstan, another country with a high prevalence of H. pylori infection (79.5%), 2 among individuals between 40 and 64 years, the prevalence of serologically diagnosed gastric atrophy was 26.8%. 40 And lastly, in a study from Slovenia, which used similar kits from Biohit Oyj, the prevalence of H. pylori infection was 76% and that of gastric atrophy was 7.3%.…”

Section: We Compared Our Gastric Atrophy Results To Those Of High And...mentioning

confidence: 99%

“…A study from Russia, using the GastroPanel® reported a prevalence gastric atrophy prevalence of 10.8% 38 . In a case–control study from Siberia involving adults aged 45‐69 years old ( n = 9360), among the controls the percentage of H. pylori infection was 90.1%, but that of gastric atrophy was 16.2% 39 . Kazakhstan, another country with a high prevalence of H. pylori infection (79.5%), 2 among individuals between 40 and 64 years, the prevalence of serologically diagnosed gastric atrophy was 26.8% 40 .…”

Section: Discussionmentioning

confidence: 99%

Nationwide survey ofHelicobacter pyloriseropositivity and gastric atrophy in Zambia

Kayamba,

Munshi,

Hankolwe

et al. 2024

Helicobacter

View full text Add to dashboard Cite

BackgroundHelicobacter pylori (H. pylori) is a common bacterial infection which predominately drives upper gastrointestinal pathology. We carried out a nationwide serological survey in response to the deficiency of robust African data on H. pylori prevalence, age of acquisition, socio‐geographic determinants, and impact on gastric physiology.Materials and MethodsThis was a cross‐sectional study of archival plasma samples collected during the Zambia Population‐based HIV impact Assessment (ZAMPHIA) 2016 survey. ZAMPHIA used a two‐stage door‐to‐door stratified cluster sample approach to collect samples from adults and children from age 0 to 59 years (n = 24,266). We randomly retrieved one fifth of these samples from each of Zambia's 10 provinces and used ELISA to test for H. pylori IgG antibodies, pepsinogen 1 and 2 and gastrin‐17. A pepsinogen 1:2 ratio of <3 was used to define gastric atrophy.ResultsThe analysis of 4050 plasma samples (30% <16 years, 53% females) revealed an overall H. pylori seroprevalence of 79%. By the age of 10 years, more than 75% of the children had H. pylori. Urban residence was associated with increased odds (OR 1.8, 95% CI 1.5–2.2, p < 0.001) and HIV infection was associated with reduced odds (OR 0.7, 95% CI 0.5–0.9, p = 0.02) of H. pylori seropositivity. Gastric atrophy was detected in 6% of H. pylori seropositive adults below 45 years of age and 9% in those between 45 and 59 years.ConclusionsWe have confirmed a high prevalence of H. pylori seropositivity in Zambia, predominantly in urban settings. The prevalence of gastric atrophy is broadly consistent with other populations around the globe, but our sample did not include adults over 60 years.

show abstract

“…Important changes in their levels were noticed in patients with perturbations of gastric homeostasis, which is excessively produced during inflammation, and severely decreased in the setting of atrophic gastritis [27]. Several studies emphasized their predictive power for detecting patients with an increased risk of gastric cancer, with the ratio between pepsinogen I and II serving as the most reliable predictor [28][29][30][31]. Interestingly, H. pylori infection was found to be significantly associated with increased levels of pepsinogens [32], while individuals with gastric cancer present significantly decreased levels of pepsinogen I and pepsinogen I/pepsinogen II ratio [33].…”

Section: The Interplay Between Host-and H Pylori-related Biomarkersmentioning

confidence: 99%

The Most Recent Insights into the Roots of Gastric Cancer

Meliț,

Mărginean,

Borka Balas

2024

Life

View full text Add to dashboard Cite

Helicobacter pylori (H. pylori) is the most common bacterial infection worldwide, usually being acquired during childhood, and its persistence into adulthood represents one of the main contributors of gastric carcinogenesis. Based on these statements, it would be of great importance to know if the most early premalignant transformation occurs in children or later since, this would enable the development of effective anti-tumorigenesis strategies. The interplay between H. pylori virulence factors, the host’s responses modified by this infection, and the gastric microecology are complex and eventually lead to the development of gastric cancer in susceptible individuals. Several biomarkers were identified as major contributors of this long-lasting process, such as pepsinogens, gastrin 17, lipid-, glucose- and iron-metabolism parameters, immunity players, aberrant bacterial DNA methylation, H. pylori virulence factors, and hallmarks of gastric dysbiosis. Several of these biomarkers were also identified in children with H. pylori infection, independently of the presence of premalignant lesions, which were also proven to be present in a subgroup of H. pylori-infected children, especially those carrying extremely virulent strains. Therefore, the most incipient premalignant gastric changes might indeed occur early during childhood, opening a promising research gate for further studies to delineate the border between infection and cancer.

show abstract

Sa1952a The First Steps in the Development of Gastric Cancer Riskometry: The Siberian Retrospective Case-Control Study. Novosibirsk State Medical University, Russian Federation

Cited by 5 publications

References 0 publications

Assessing the utility of pepsinogens and gastrin-17 in gastric cancer detection

Assessing the utility of pepsinogens and gastrin-17 in gastric cancer detection

Nationwide survey ofHelicobacter pyloriseropositivity and gastric atrophy in Zambia

The Most Recent Insights into the Roots of Gastric Cancer

Contact Info

Product

Resources

About