SA31 Methodological Approaches for Assessing Certainty of the Evidence in Umbrella Reviews: A Scoping Review

Sadoyu, S; Tanni, KA; Punrum, N; Paengtrai, S; Kategeaw, W; Promchit, N; Nm, Lai; Thakkinstian, A; Ngorsuraches, S; Bangpan, M; Veettil, SK; Chaiyakunapruk, N

doi:10.1016/j.jval.2022.04.1697

Cited by 2 publications

(4 citation statements)

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“…The literature reports several advantages regarding this type of protocol publishing: (a) increased clarity surrounding systematic review conduct and reporting [ 33 , 38 ]; (b) it helps to reduce the bias of “positive” reviews selection; and (c) avoids the duplication of the research team’s efforts by making protocol publicly available, while conducting with more time the umbrella review.…”

Section: Discussionmentioning

confidence: 99%

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Autism Spectrum as an Etiologic Systemic Disorder: A Protocol for an Umbrella Review

Lopes

Rodrigues²,

Baccarin³

et al. 2022

Healthcare

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Autism spectrum disorder (ASD) is the most common neurodevelopmental disorder with a huge prevalence increasing every year (1/44 children). Still diagnosed as a mental disorder, the last 10 years of research found possible causes, risks, genetics, environmental triggers, epigenetics, metabolic, immunological, and neurophysiological unbalances as relevant aetiology. Umbrella methodology is the highest level of scientific evidence, designed to support clinical and political decisions. A literature search for autism aetiology, pathophysiology, or causes, conducted in the last 10 years, at PubMed, Embase, Cochrane, Scopus, and the Web of Science, resulted in six umbrella reviews. Nevertheless, only one quantitative analysis reported risk factors and biomarkers but excluded genetics, experiments on animal models, and post-mortem studies. We grouped ASD’s multi-factorial causes and risks into five etiological categories: genetic, epigenetic, organic, psychogenic, and environmental. Findings suggest that autism might be evaluated as a systemic disorder instead of only through the lens of mental and behavioural. The overview implications of included studies will be qualitatively analysed under ROBIS and GRADE tools. This umbrella review can provide a rational basis for a new urgent health policy to develop better and adequate integrated care services for ASD. The methodological protocol has the register CRD42022348586 at PROSPERO.

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Section: Discussionmentioning

confidence: 99%

“…This study protocol is a review of reviews design using qualitative analysis. This design type is the highest level of evidence and is best known as the umbrella review [ 33 , 34 ].…”

Section: Methodsmentioning

confidence: 99%

Autism Spectrum as an Etiologic Systemic Disorder: A Protocol for an Umbrella Review

Lopes

Rodrigues²,

Baccarin³

et al. 2022

Healthcare

View full text Add to dashboard Cite

show abstract

“…At present, there are no official standards for determining the certainty of evidence in performing URs. 28 The certainty of evidence acquired from URs is a crucial element supporting decisions on the course of treatment or policy since it shows the confidence in the conclusions drawn from numerous studies. 29 Therefore, explicit directions for the process of assessing certainty in evidence in UR are expected to be provided after various stages of debate.…”

Section: How To Perform An Urmentioning

confidence: 99%

“…Although GRADE provides a comprehensive framework for evaluating evidence, the majority of the essential information is not provided in the original study, which represents a restriction. 28 Reaserchers are not universally following the guidelines that have been published so far, and there remain issues that need to be solved, such as those that conflict with the guidelines or prevent their usage because of their omission when conducting URs. To ensure an accurate and rigorous assessment of evidence in URs, more sophisticated guidelines for the conduct of URs are required.…”

Section: Limitations Of Ursmentioning

confidence: 99%

Introduction to Umbrella Reviews as a Useful Evidence-Based Practice

Choi

Kang

2023

J Lipid Atheroscler

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The umbrella review (UR) is a novel methodological approach that has been established to address the ever-expanding research volume of published systematic reviews. In this study, we examined the rationale underlying URs, the concepts and goals of URs, and their applicability in clinical settings. Additionally, we briefly assessed the process of conducting URs and discussed the current challenges in this regard. URs are used to integrate, evaluate, and synthesize the findings of related systematic reviews. By organizing and summarizing the abundant information in accordance with the level of evidence, URs can serve as a useful methodological tool and provide appropriate entry points to clinicians or decision-makers in the medical field. Considering the availability of many suitable interventions for specific conditions in a broad field, URs can enable evidence-based decision-making and offer a broad perspective for the resolution of issues in healthcare by summarizing the evidence and providing directions on a variety of topics. URs are clearly contributing to the management of the deluge of evidence in evidence-based medicine. However, despite the availability of several directions for conducting URs, some points of confusion persist, especially when determining the certainty of evidence. Therefore, advanced guidelines for the appropriate performance of URs are required to provide more reliable evidence through URs.

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SA31 Methodological Approaches for Assessing Certainty of the Evidence in Umbrella Reviews: A Scoping Review

Cited by 2 publications

References 0 publications

Autism Spectrum as an Etiologic Systemic Disorder: A Protocol for an Umbrella Review

Autism Spectrum as an Etiologic Systemic Disorder: A Protocol for an Umbrella Review

Introduction to Umbrella Reviews as a Useful Evidence-Based Practice

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