SAA and CRP are potential indicators in distinction and severity assessment for children with influenza

Abstract

The clinical values of C-reactive protein (CRP) and serum amyloid A (SAA) to distinguish nonsevere from severe influenza in children are rarely reported. Methods: Baseline characteristics and laboratory results were collected and analyzed. Receiver operating characteristic (ROC) curve analysis was used for combined detection of indicators for children with influenza, and scatter-dot plots were used to compare the differences between non-severe and severe influenza. Results: Children with influenza B had more bronchitis and pneumonia (P < 0.05) and children with influenza A had more other serious symptoms (P = 0.015). Lymphocyte count, neutrophil count, neutrophil-to-lymphocyte ratio (NLR), CRP, and SAA performed differently among children with influenza A and B. Joint detection of SAA and other indicators could better separate healthy children from children with influenza than single indicator detection. The CRP and SAA levels of children with severe influenza B infection and SAA levels of children with severe influenza A infection were significantly elevated compared with children with non-severe influenza (P < 0.05). Conclusions: SAA and CRP could be potential indicators in distinction and severity assessment for children with influenza; however, age should be taken into account when using them in children with influenza B.

Serum amyloid A‐to‐albumin ratio as a potential biomarker to predict the activity, severity, and poor prognosis of systemic lupus erythematosus

“…An important clinical feature of autoimmune diseases is the disorder of inflammatory factors, such as serum amyloid A (SAA), C‐reactive protein (CRP), albumin (ALB), erythrocyte sedimentation rate (ESR), and neutrophil‐to‐lymphocyte ratio, 8 , 9 which have been proved to be related with the severity and prognosis of the disease, and the predictive value of different indicators are different. Hwang YG et al 10 showed that with the increase of disease activity in rheumatoid arthritis (RA), the levels of CRP and SAA increased, but SAA could better respond to this trend.…”

Deficiency of C-reactive protein or human C-reactive protein transgenic treatment aggravates influenza A infection in mice

“…Transgenic or passively administered human CRP was protective against lethal bacterial infection in transgenic mice (6). In contrast, increasing studies have shown that excessively high CRP level was a risk factor for virus infection's severity or fatal outcome, including influenza (8,17,(26)(27)(28). Studies have demonstrated that the antiviral immune response represents a balancing act between the elimination of the virus and immune-mediated pulmonary injury (29).…”

Vaikų Gripo Komplikacijų Dažnis Ir Rizikos Veiksniai

“…Tyrėjai pabrėžia, kad vaikams, sergantiems gripu ir turintiems gretutinių lėtinių ligų, komplikacijos išsivysto dažniau [6]. A tipo gripu sergantys vaikai dažnai patiria sunkesnes komplikacijas, nei B tipo gripo pacientai [11]. Informacijos apie sunkias su B tipo gripu susijusias komplikacijas literatūroje yra nedaug, tačiau australų tyrime buvo pastebėta, kad vertinant pastarųjų 10 metų gripo sezonus, B tipo gripas sukėlė didesnį vaikų sergamumą ir dažniau buvo siejamas su sunkesnių komplikacijų, tokių kaip ūminis inkstų nepakankamumas, rabdomiolizė ir kardiovaskulinės sistemos sutrikimai išsivystymu, nei A tipo gripas [4].…”

“…S. Zou ir kt. autorių aprašytame tyrime buvo pastebėta, kad vaikams, sergantiems B tipo gripu, pneumonija išsivystė dažniau, nei sergantiems A tipo gripu [11]. Gripo virusinė infekcija gali sukelti ir įvairias neurologines komplikacijas, įskaitant traukulius, encefalopatiją, encefalitą ir Guillain-Barré sindromą.…”

“…Singapūro mokslininkų atliktame tyrime nustatyta, kad A tipo gripu sergantys vaikai dažniau patyrė neurologinių komplikacijų, nei sergantieji B tipo gripu [18]. Vertinant bendrojo kraujo tyrimo pokyčius ir komplikacijų išsivystymo riziką, keleto tyrimų duomenimis, limfopenija, trombocitopenija ir žymiai padidėjęs CRB buvo dažniau susiję su vaikų komplikuoto gripo atvejais [11,19].…”