Saccharomonopyrones A–C, New α-Pyrones from a Marine Sediment-Derived Bacterium Saccharomonospora sp. CNQ-490

Yim, Chae Yoon; Le, Tu C.; Lee, Tae Gu; Yang, Inho; Choi, Hansol; Lee, Jusung; Kang, Kyung Yun; Lee, Jin Hyung; Lim, Kyung Min; Yee, Sung Tae; Kang, Heonjoong; Nam, Sang Jip; Fenical, William

doi:10.3390/md15080239

Cited by 20 publications

(16 citation statements)

References 33 publications

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“…Chemical structures of the active compounds were established from the interpretation of 2D NMR spectroscopic data and comparison of NMR data with Lodopyridone A. Lodopyridones B and C exhibited weak inhibitory activities on the β-site amyloid precursor protein-cleaving enzyme 1 (Le et al 2017). Yim et al (2017) purified three new α-pyrones, saccharomonopyrones A-C from the marine sediment-derived actinobacterium Saccharomonospora sp. CNQ-490.…”

Section: Pancreatic Lipase Inhibition Assaymentioning

confidence: 99%

Bioactive compounds from mangrove derived rare actinobacterium Saccharomonospora oceani VJDS-3

et al. 2018

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A rare actinobacterium was isolated from Nizampatnam mangrove ecosystem of Andhra Pradesh, India, and was screened for its ability to produce bioactive compounds. The potential strain was identified as VJDS-3 by polyphasic taxonomy. Purification of the biologically active compounds by column chromatography led to the isolation of three compounds, namely methoxy ethyl cinnamate (ethyl(E)-3-(4-methoxyphenyl)acrylate) (), 4-hydroxy methyl cinnamate (methyl(E)-3-(4-hydroxyphenyl)acrylate) () and 4-methylbenzoic acid (). The structure of the compounds was elucidated on the basis of spectroscopic analysis including FTIR, EIMS, HNMR andCNMR spectroscopies. The antimicrobial activity of the bioactive compounds produced by the strain was tested against a panel of bacteria and fungi, and expressed in terms of minimum inhibitory concentration. Compound (R1) exhibited higher antimicrobial potential (50 µg/ml) against , and compared to R2 and R3. Antioxidant activity of compounds was determined by DPPH and ABTS radical scavenging activities. The results revealed that compound R3 effectively scavenged DPPH (73.08 ± 1.29) and ABTS (99.74 ± 0.00) radicals at a concentration of 25 and 50 µg/ml, respectively. Antidiabetic and anti-obesity activities were evaluated by inhibitory potential of compounds against alpha-glucosidase, alpha-amylase and pancreatic lipase by spectrophotometric assays. Compound R1 showed effective inhibition against alpha-glucosidase (66.8 ± 1.2) at 20 µg/ml while moderate to weak activities were found against alpha-amylase and pancreatic lipase. To the best of our knowledge, this is the first report on the isolation of supra said compounds from the genus

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Section: Pancreatic Lipase Inhibition Assaymentioning

confidence: 99%

Bioactive compounds from mangrove derived rare actinobacterium Saccharomonospora oceani VJDS-3

et al. 2018

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“… 2010 ) and Saccharomonopyrone A (Yim et al. 2017 ) have been identified to date. Among Actinobacteria, the majority of the biologically active compounds have been discovered from the genus Streptomyces (Berdy 2005 ; Zotchev 2012 ).…”

Section: Introductionmentioning

confidence: 99%

Potential of rare actinomycetes in the production of metabolites against multiple oxidant agents

Mohammadipanah

Momenilandi

2017

Pharmaceutical Biology

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Context: Actinobacteria are a precious source of novel bioactive metabolites with potential pharmaceutical applications.Objectives: Representatives of 11 genera of rare Actinobacteria were selected for the evaluation of antioxidant activity.Material and methods: Fermentation broths of the Actinobacteria were extracted and dosage of 10 to 2000 µg/mL were applied for in vitro antioxidant-related bioassays. Cytotoxicity was assessed at the concentration of 2.5–20 µg/mL.Results: In the DPPH scavenging activity, 15 out of 52 extracts showed 17.0–26.8% activity in quantitative evaluation. Metabolites of five prominent antioxidant producing strains protected the DNA (pUC19) against UV-induced photolyzed H2O2-oxidative degradation. The potent antioxidant extracts inhibited two oxidative enzymes of xanthine oxidase in the range of 17.5–45.2% (three extracts had IC50 less than allopurinol) and lipoxygenase in the range of 36–55% (all five extracts had IC50 values less than daidzein). All these extracts could also protect eythrocytes from iron-induced hemolysis with ED50 values in a range of 0.014–1.25 mg/mL. Growth restoration of the yeast cells lacking the sod1 gene was observed by the antioxidant metabolite of Saccharothrix ecbatanensis UTMC 537 at the concentration of 1 mg/mL.Conclusions: The presence of nonidentical metabolites might be responsible for antioxidant and enzyme inhibitory activities of S. ecbatanensis, newly described actinobacterium in family Pseudonocardiaceae. The scavenging of the free electrons, protection of DNA and model yeast cells against oxidative stress, in addition to the inhibition of the oxidating enzymes are the main mechanisms of the antioxidant effect of the introduced resource in this study.

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“…The synthetic routs of the proposed compounds are outlined in Scheme 1. Our initial goal was to prepare(Z)-6-bromo-3-((2E,3E)-2-(hydroxyimino)-4-(4-methoxyphenyl)but-3-enylidene)indolin-2-one (6). This was synthesized through the addition of benzylidene acetones with isatins in presence of catalytic amount of Larginine at which the nal hydroxyl product 4 was separated in Fig.…”

Section: Chemistrymentioning

confidence: 99%

“…3.1.4. Synthesis of (E)-6-bromo-3-((2E,3E)-2-(hydroxyimino)-4-(4-methoxyphenyl)but-3-enylidene)indolin-2one (6). A mixture of (5) (0.1 mmol) NH 2 OH$HCl (0.2 mmol) in ethanol (10 mL) and pyridine (0.2 mmol) was reuxed for 6 hours.…”

Section: Chemicals and Instrumental Analysismentioning

confidence: 99%

“…3 Furthermore, the recent discovery of numerous taxonomically unique marine-derived actinomycetes, 3,4 was associated with frequent isolation of novel bioactive secondary metabolites, and still offers a promising source for the discovery of further unusual natural products with diverse biological activity. 5,6 Many of these secondary metabolites are clinically useful anticancer drugs, such as anthracyclines represented in daunomycin, and doxorubicin, bleomycin and actinomycin D derived from peptides pentostatin regarded as antimetabolites, in addition to carzinophilin, and mitomycins. [7][8][9] In 2019, ULDF5 was a new indole derived compound isolated from the metabolic extracts of the marine actinomycetes that is structurally similar to staurosporine and it seemed to exhibit cytotoxic activity against HeLa cell line with IC 50 0.075 mg mL À1 .…”

Section: Introductionmentioning

confidence: 99%

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Saccharomonosporine A inspiration; synthesis of potent analogues as potential PIM kinase inhibitors

et al. 2020

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Saccharomonopyrones A–C, New α-Pyrones from a Marine Sediment-Derived Bacterium Saccharomonospora sp. CNQ-490

Cited by 20 publications

References 33 publications

Bioactive compounds from mangrove derived rare actinobacterium Saccharomonospora oceani VJDS-3

Bioactive compounds from mangrove derived rare actinobacterium Saccharomonospora oceani VJDS-3

Potential of rare actinomycetes in the production of metabolites against multiple oxidant agents

Saccharomonosporine A inspiration; synthesis of potent analogues as potential PIM kinase inhibitors

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