Saddle Pulmonary Embolism in a Cancer Patient with Thrombocytopenia: A Treatment Dilemma

Zalpour, Ali; Hanzelka, Katy M.; Patlan, John T.; Rozner, Marc A.; Yusuf, Salim

doi:10.4061/2011/835750

Cited by 2 publications

(2 citation statements)

References 37 publications

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“…As mentioned before, risk of VTE is increased in COVID-19 infection particularly in pregnant women, therefore initiation of anticoagulants was recommended in this population [6]. D-dimer level of the patient increased to 1290 µg/L, the level is above of D-dimer threshold (1250 µg/L) in third-trimester pregnancy [10]. The existence of thrombocytopenia and emergency cesarean section should be undergone, anticoagulant treatment was decided to be postponed and planned to be administered after thrombocyte level increases.…”

Section: Discussionmentioning

confidence: 99%

Maternal Death Caused by Severe-Critical COVID-19 in Jakarta: Case Series

Djusad

Meutia

Suastika

et al. 2021

Open Access Maced J Med Sci

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BACKGROUND: As of January 2021, Indonesia had the 21st highest number of total COVID-19 cases and the 17th highest total deaths among all countries. COVID-19 infection in pregnant women seems to negatively affect both maternal and neonatal outcomes. CASE REPORT: We describe four cases of pregnant women confirmed with severe and critical COVID-19 that resulted in maternal death from November until December 2020. The first case was complicated with thrombocytopenia, her condition quickly deteriorated post-delivery. Pulmonary embolism was suspected as the cause of death. Second and third cases were complicated with preeclampsia, obesity, and advanced maternal age. Second case came in sepsis condition. Her SARS CoV-2 RTPCR swab test came out after her death. Third patient did not have COVID-19 symptoms at admission. She starts having symptoms on second day and was confirmed positive a day after. She falls in septic shock. Fourth patient has history of fever, cough, and dyspnea. She was confirmed positive on first day and her condition worsened, diagnosed with bacterial co-infection sepsis on day eight. All patients underwent cesarean section. CONCLUSION: Limited information and studies for COVID-19 management in pregnant women are challenging for obstetricians. Management should be individualized weighing the benefit and risks in presence of comorbidities or accompanying disease.

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Section: Discussionmentioning

confidence: 99%

Maternal Death Caused by Severe-Critical COVID-19 in Jakarta: Case Series

Djusad

Meutia

Suastika

et al. 2021

Open Access Maced J Med Sci

View full text Add to dashboard Cite

show abstract

“…There is no evidence on the use of thrombolysis in patients with thrombocytopenia [13]. Cases are reported in the literature where the use of endoluminal thrombolysis in patients with heparin-induced purpura thrombocytopenia did not increase the risk of bleeding [14, 15].…”

Section: Discussionmentioning

confidence: 99%

Submassive Pulmonary Thromboembolism in a Patient with Thrombocytopenia: Therapeutic Challenge

Tovar

Perdomo

Molina

et al. 2019

Case Reports in Critical Care

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Venous thromboembolic disease is an important cause of mortality worldwide. A widely recognized risk factor is active neoplasia, mainly hematological tumors, in which associated thrombocytopenia can be a frequent complication. We present the case of a patient with submassive pulmonary thromboembolism associated with severe thrombocytopenia with signs of right heart failure and a requirement for systemic thrombolysis and anticoagulation, however with absolute contraindication for them. The case establishes a therapeutic challenge for the treating group, leading us to carry out an extensive search of the literature and propose a management algorithm in this complex situation.

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Saddle Pulmonary Embolism in a Cancer Patient with Thrombocytopenia: A Treatment Dilemma

Cited by 2 publications

References 37 publications

Maternal Death Caused by Severe-Critical COVID-19 in Jakarta: Case Series

Maternal Death Caused by Severe-Critical COVID-19 in Jakarta: Case Series

Submassive Pulmonary Thromboembolism in a Patient with Thrombocytopenia: Therapeutic Challenge

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