Safe and effective glycaemic control in premature infants: observational clinical results from the computerised STAR-GRYPHON protocol

Knopp, Jennifer L.; Lynn, Adrienne; Chase, J. Geoffrey

doi:10.1136/archdischild-2017-314072

Cited by 9 publications

(1 citation statement)

References 43 publications

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“…17,[27][28][29][30][31][32] The stochastic targeted (STAR), in particular, is focused on using patient-specific time-varying insulin sensitivity 33 to provide safe, effective control to essentially all patients with reduced workload and increased nutrition delivery. [34][35][36][37] STAR uses a well-validated physiological model 38 and a user-friendly interface designed for accuracy 39,40 to dose insulin based on risk of future changes in insulin sensitivity (S I ), 41,42 an approach proven to generalise across adult 37,43 and neonatal ICUs, [44][45][46] as well as with other technologies. 47,48 This protocol was adopted in Malaysia 29 after successful studies internationally.…”

Section: Introductionmentioning

confidence: 99%

<p>Assessment of Glycemic Control Protocol (STAR) Through Compliance Analysis Amongst Malaysian ICU Patients</p>

Abu-Samah¹,

Razak²,

Jamaludin³

et al. 2020

MDER

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This paper presents an assessment of an automated and personalized stochastic targeted (STAR) glycemic control protocol compliance in Malaysian intensive care unit (ICU) patients to ensure an optimized usage. Patients and Methods: STAR proposes 1-3 hours treatment based on individual insulin sensitivity variation and history of blood glucose, insulin, and nutrition. A total of 136 patients recorded data from STAR pilot trial in Malaysia (2017-quarter of 2019*) were used in the study to identify the gap between chosen administered insulin and nutrition intervention as recommended by STAR, and the real intervention performed. Results: The results show the percentage of insulin compliance increased from 2017 to first quarter of 2019* and fluctuated in feed administrations. Overall compliance amounted to 98.8% and 97.7% for administered insulin and feed, respectively. There was higher average of 17 blood glucose measurements per day than in other centres that have been using STAR, but longer intervals were selected when recommended. Control safety and performance were similar for all periods showing no obvious correlation to compliance. Conclusion: The results indicate that STAR, an automated model-based protocol is positively accepted among the Malaysian ICU clinicians to automate glycemic control and the usage can be extended to other hospitals already. Performance could be improved with several propositions.

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