Safeguarding anaesthesia research from spin

Magoon, Rohan; Jose, Jes

doi:10.1016/j.bja.2020.08.042

Cited by 26 publications

(23 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The study, however, is inherently limited by its retrospective design that is susceptible to residual confounding. 30 The exclusion of patients on mechanical ventilation, preoperative IABP, AF, etc. who have high baseline predisposition to development of MACCE might have caused leftward skewed data results.…”

Section: Discussionmentioning

confidence: 99%

Preoperative Combined Adiposity–Nutritional Index Predicts Major aDverse Cardiac and Cerebral Events following Off-pump coRonary Artery Revascularization (PANDORA): A Retrospective Single-Center Study

Bansal

Magoon

Dey

et al. 2021

Journal of Cardiac Critical Care TSS

Self Cite

View full text Add to dashboard Cite

Background The metabolic–nutritional profile of coronary artery disease (CAD) patients can be an important outcome determinant. A high visceral adiposity index (VAI) and a low prognostic nutritional index (PNI) have been described to predict major adverse cardiac and cerebral events (MACCE) in nonoperative settings and poor cardiac-surgical outcomes, respectively. The present study evaluated the MACCE-predictive value of the two indices, in isolation and as a combined adiposity–nutritional index (CANI = VAI/PNI) in patients undergoing off-pump coronary artery bypass grafting (OPCABG). Methods The retrospective study was conducted in 1207 OPCABG patients at a tertiary cardiac care center. Thirty-day postoperative data was evaluated for the development of MACCE, defined by any of the following: cardiac arrest, ST-segment elevation myocardial ischemia (STEMI), repeat coronary revascularization, or stroke. The perioperative characteristics of the MACCE and no-MACCE groups were analyzed for the predictors of postoperative MACCE. Results One-hundred thirty-two patients (10.93%) developed MACCE postoperatively. On univariate analysis, age, EuroSCORE II, ejection fraction, diabetes mellitus, asymptomatic carotid artery disease, left main (LM) disease, PNI, and VAI predicted MACCE. Subsequent to multivariate analysis, age, EuroSCORE II, and CANI were the independent predictors. The MACCE predictive cutoffs of VAI, PNI, and CANI were 3.2, 38.46, and 0.075 (area under the curve [AUC]; sensitivity; specificity: 0.64; 77%; 81.3%, 0.77; 92.6%, 65%, 0.78; 64.5%; 80.2%, respectively). CANI correlated positively with duration of mechanical ventilation, length of intensive care unit (ICU) stay, and mean postoperative vasoactive inotropic scores (VIS). CANI ≥ 0.075 was also associated with a higher incidence of postoperative atrial fibrillation, low cardiac output syndrome, and acute kidney injury. Conclusions CANI emerged as an independent predictor of MACCE following OPCABG.

show abstract

Section: Discussionmentioning

confidence: 99%

Preoperative Combined Adiposity–Nutritional Index Predicts Major aDverse Cardiac and Cerebral Events following Off-pump coRonary Artery Revascularization (PANDORA): A Retrospective Single-Center Study

Bansal

Magoon

Dey

et al. 2021

Journal of Cardiac Critical Care TSS

Self Cite

View full text Add to dashboard Cite

show abstract

“…Perioperative pain following cervical rib excision can be successfully managed with the assistance of multimodal OFA protocols, as in the index case series. While such OFA protocols captivates attention for their potential of overcoming the ORADEs, larger prospective studies with age- and gender-matched controls 21 are awaited before adoption in day-to-day clinical practice can be routinely recommended.…”

Section: Discussionmentioning

confidence: 99%

Feasibility of Opioid-Free Anesthesia for Cervical Rib Excision: A Case Series and Review of Literature

Dey

Kohli

Magoon

et al. 2021

Journal of Cardiac Critical Care TSS

Self Cite

View full text Add to dashboard Cite

Background Perioperative pain management following cervical rib excision can be compounded in the background of chronic pain disorder caused by the neurovascular compression. The former mandates an enhanced analgesic requirement wherein the perioperative opioid use, in particular, can be associated with a peculiar adverse-effect profile and abuse potential. Appropriate to the context, an opioid-free anesthesia (OFA) protocol can be instrumental in minimizing the incidence of the aforementioned. Case Series While two patients necessitated OFA owing to opioid contraindication, the formulated protocol was evaluated in another six consecutive patients posted for elective cervical rib excision. A combined paravertebral block and superficial cervical plexus block was employed alongside general anesthesia. Intravenous dexmedetomidine and lignocaine assisted the conduct of OFA, and paracetamol dosing was continued into the postoperative period. Intraoperative rescue analgesia was ensured by a ketofol bolus (1:1 mixture of ketamine and propofol) whereas intravenous diclofenac was used for postoperative rescue analgesia. Results OFA could be successfully contemplated in all eight patients. A single bolus rescue dose of ketofol had to be administered in two patients intraoperatively and diclofenac had to be administered as postoperative rescue analgesic in two patients. There was no incidence of postoperative nausea/vomiting or any block-related complications. The postoperative stay was uneventful with an acceptable patient satisfaction. Conclusion The index experience reiterates the fact that a prudent combination of nonopioid multimodal analgesics with case-based locoregional techniques can feature as a successful OFA protocol, albeit mandating future prospective studies in this novel area of clinical interest.

show abstract

“…A few scholars have addressed ethical issues in speci c elds, including authorship, participant recruitment, con icts of interest, and accurate representation of data [e.g., 30], or assessing threats to social validity [16]. Still others have argued the quality of scienti c knowledge has long been diminished by racism, sexism and colonialism [31] and is often manipulated to increase potential impact through exaggeration [22,23].…”

Section: Full Textmentioning

confidence: 99%

“…One frequently mentioned aspect is the role of senior faculty in mentoring and guiding junior researchers by modelling ethical research behaviors and hands-on guidance [19][20][21]. Additionally, some recent literature touts Open Science for its potential to increase transparency and reduce over-sensationalism [22,23].…”

Section: Full Textmentioning

confidence: 99%

Challenges and Threats to Quality in Scholarly Knowledge Production: Views of Selected Stakeholders from 17 Countries

Starkey

Koerber

Cummins

et al. 2022

Preprint

View full text Add to dashboard Cite

This study applies Harvey and Green’s (1993) model of quality to scholarly knowledge production. Although studies of quality in higher education have been commonplace for decades, there is a gap in understanding quality in terms of research production from the stakeholder’s perspective. This study begins to fill that gap through a qualitative interview study of quality in the knowledge production process. Stakeholders in all parts of the scholarly knowledge production process, from 17 countries are included in the data sample. Interview data are analyzed through the conceptualizations of quality developed by Harvey and Green (1993), extending the use of the model into the realm of the knowledge production process. Definitions and challenges of quality in producing scholarly knowledge are discussed. The findings indicate a rift between the institutional view of quality and the individual perceptions of quality, suggesting the need for policies aimed at addressing a unification of scholarly knowledge production efforts.

show abstract

Safeguarding anaesthesia research from spin

Cited by 26 publications

References 13 publications

Preoperative Combined Adiposity–Nutritional Index Predicts Major aDverse Cardiac and Cerebral Events following Off-pump coRonary Artery Revascularization (PANDORA): A Retrospective Single-Center Study

Preoperative Combined Adiposity–Nutritional Index Predicts Major aDverse Cardiac and Cerebral Events following Off-pump coRonary Artery Revascularization (PANDORA): A Retrospective Single-Center Study

Feasibility of Opioid-Free Anesthesia for Cervical Rib Excision: A Case Series and Review of Literature

Challenges and Threats to Quality in Scholarly Knowledge Production: Views of Selected Stakeholders from 17 Countries

Contact Info

Product

Resources

About