Safeguards in the use of DNA databanks in genomic research

Abstract

Genomic research, which uses DNA to identify the gene(s) responsible for complex diseases, relies upon large DNA databases to facilitate population-based research. These databases derive their power from integrating different kinds of information about large samples of individuals: genetic and clinical data and data on health, lifestyle, and environment. Using statistical analysis, the databases can be used to analyze correlations that may enable new therapeutic developments.The use of DNA databanks in genomic research brings new challenges related to the scope of research as well as to the nature and use of the samples and information archived in such databases. This report identifies these issues and considers their relation to the current standard of informed consent in human research.