Safety and Efficacy of Alprostadil Sterile Powder (S. Po., CAVERJECT&lt;sup&gt;&amp;reg;&lt;/sup&gt;) in Diabetic Patients with Erectile Dysfunction

Tsai, Yuh‐Shyan; Lin, Johnny Shinn‐Nan; Lin, Yung Ming

doi:10.1159/000020277

Cited by 22 publications

(11 citation statements)

References 10 publications

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“…52 In a study on Asian diabetic patients treated with intracavernosal prostaglandin E 1 , 76.5% of ED patients reported satisfactory sexual activity. 53 In another study conducted in Taiwan (China), the overall satisfaction with penile prosthesis surgery was 86.6%. 54 The armamentarium of traditional and complementary medicine available in Asia is shown in Supplement.…”

Section: Treatmentmentioning

confidence: 97%

Male sexual dysfunction in Asia

Ho¹,

Singam²,

Hong³

et al. 2011

Asian J Androl

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Sex has always been a taboo subject in Asian society. However, over the past few years, awareness in the field of men's sexual health has improved, and interest in sexual health research has recently increased. The epidemiology and prevalence of erectile dysfunction, hypogonadism and premature ejaculation in Asia are similar in the West. However, several issues are specific to Asian males, including culture and beliefs, awareness, compliance and the availability of traditional/complementary medicine. In Asia, sexual medicine is still in its infancy, and a concerted effort from the government, relevant societies, physicians and the media is required to propel sexual medicine to the forefront of health care. Asian Journal of Andrology (2011) 13, 537-542; doi:10.1038/aja.2010.135; published online 6 June 2011Keywords: Asia; erectile dysfunction; health; hypogonadism; male; premature ejaculation; sex INTRODUCTIONUntil recently, men's sexual health has taken a backseat in the planning and implementation of health care. When Viagra (sildanefil) burst onto the scene more than a decade ago, it opened up the floodgates for research and development on men's sexual health. As a result, a previously taboo subject was transformed into a popular topic, even in Asia. Being a conservative society, male sexual health was initially embraced with trepidation in Asia. In contrast, the more open culture of the West has seen significant progress in the field of sexual medicine. The purpose of this review is to examine the burden of men's sexual health in Asia and to identify issues that are unique to Asian men in order to develop strategies for the improvement of men's health care in Asia.

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Section: Treatmentmentioning

confidence: 97%

Male sexual dysfunction in Asia

Ho¹,

Singam²,

Hong³

et al. 2011

Asian J Androl

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“…Fifty-five per cent of patients require more than 20 µg of prostaglandin E 1 . The dropout rate is high, however, and complaints of penile pain are reported in 61% of patients; however, it is tolerated by most patients (50). Although less efficacious than ICI, an intraurethral prostin can be a good alternative for patients who do not wish more invasive therapies.…”

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confidence: 99%

Diabetes and male sexual function

Rehman¹,

Beshay²,

Carrier³

2001

Sex Reprod Med

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“…In addition, intracavernosal or intraurethral PGE 1 formulations may cause mild to severe discomfort at a rate of approximately 10% of all self‐administration events in a significant population of men (32–58%) with erectile dysfunction [14–18]. In particular, men with diabetes or those who have had radical prostatectomy surgery appear to be the most susceptible to experiencing pain or discomfort upon PGE 1 administration [19–22]. Because of the numerous and diverse biological actions of prostanoids, the molecular mechanisms involved in pain remain unclear.…”

Section: Discussionmentioning

confidence: 99%

Pharmacological and Functional Characterization of Novel EP and DP Receptor Agonists: DP1 Receptor Mediates Penile Erection in Multiple Species

Brugger

Kim

Araldi

et al. 2008

The Journal of Sexual Medicine

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Introduction Despite the widespread use of prostaglandin E1 as an efficacious treatment for male erectile dysfunction for more than two decades, research on prostanoid function in penile physiology has been limited. Aim To characterize the pharmacological and physiological activity of novel subtype-selective EP and DP receptor agonists. Methods Radioligand binding and second messenger assays were used to define receptor subtype specificity of the EP and DP agonists. Functional activity was further characterized using isolated human and rabbit penile cavernosal tissue in organ baths. In vivo activity was assessed in rabbits and rats by measuring changes in cavernous pressure after intracavernosal injection of receptor agonists. Main Outcome Measures Receptor binding and signal transduction, smooth muscle contractile activity, erectile function. Results In organ bath preparations of human cavernosal tissue contracted with phenylephrine, EP2- and EP4-selective agonists exhibited variable potency in causing relaxation. One of the compounds caused mild contraction, and none of the compounds was as effective as PGE1 (EC50 =0.23 µM). There was no consistent correlation between the pharmacological profile (receptor binding and second messenger assays) of the EP agonists and their effect on cavernosal tissue tone. In contrast, the DP1-selective agonist AS702224 (EC50 =29 nM) was more effective in relaxing human cavernosal tissue than either PGE1, PGD2 (EC50 =58 nM), or the DP agonist BW245C (EC50 =59 nM). In rabbit cavernosal tissue, PGE1 and PGD2 caused only contraction, while AS702224 and BW245C caused relaxation. Intracavernosal administration of AS702224 and BW245C also caused penile tumescence in rabbits and rats. For each compound, the erectile response improved with increasing dose and was significantly higher than vehicle alone. Conclusions These data suggest that AS702224 is a potent DP1-selective agonist that causes penile erection. The DP1 receptor mediates relaxation in human cavernosal tissue, and stimulates pro-erectile responses in rat and rabbit. Thus, rabbits and rats can be useful models for investigating the physiological function of DP1 receptors.

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Safety and Efficacy of Alprostadil Sterile Powder (S. Po., CAVERJECT<sup>®</sup>) in Diabetic Patients with Erectile Dysfunction

Cited by 22 publications

References 10 publications

Male sexual dysfunction in Asia

Male sexual dysfunction in Asia

Diabetes and male sexual function

Pharmacological and Functional Characterization of Novel EP and DP Receptor Agonists: DP1 Receptor Mediates Penile Erection in Multiple Species

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