Safety and efficacy of global intracoronary administration of cardiosphere-derived cells or conditioned medium immediately after coronary reperfusion in rats

Vakrou, Styliani; Nana, Maria; Nanas, Ioannis; Nana-Leventaki, E; Bonios, Michael; Kapelios, Chris J.; Nanas, John N.

doi:10.1016/j.hjc.2019.03.001

Cited by 3 publications

(2 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Cardiosphere-derived cells transplantation elicits cardioprotection function that has been elucidated in different animal models with MI injury ( 9 , 42 , 43 ). We showed that MI mice exhibited severe cardiac dysfunction with cardiomyocyte necrosis, fibrosis, and thinning of the ventricular wall, while iECDCs transplanted hearts displayed better contractility and reduced fibrosis.…”

Section: Discussionmentioning

confidence: 99%

Epicardium-Derived Tbx18+ CDCs Transplantation Improve Heart Function in Infarcted Mice

Guo

Geng

Qin

et al. 2022

Front. Cardiovasc. Med.

View full text Add to dashboard Cite

Cardiosphere-derived cells (CDCs) constitute a cardiac stem cell pool, a promising therapeutics in treating myocardial infarction (MI). However, the cell source of CDCs remains unclear. In this study, we isolated CDCs directly from adult mouse heart epicardium named primary epicardium-derived CDCs (pECDCs), which showed a different expression profile compared with primary epicardial cells (pEpiCs). Interestingly, pECDCs highly expressed T-box transcription factor 18 (Tbx18) and showed multipotent differentiation ability in vitro. Human telomerase reverse transcriptase (hTERT) transduction could inhibit aging-induced pECDCs apoptosis and differentiation, thus keeping a better proliferation capacity. Furthermore, immortalized epicardium CDCs (iECDCs) transplantation extensively promote cardiogenesis in the infracted mouse heart. This study demonstrated epicardium-derived CDCs that may derive from Tbx18+ EpiCs, which possess the therapeutic potential to be applied to cardiac repair and regeneration and suggest a new kind of CDCs with identified origination that may be followed in the developing and injured heart.

show abstract

Section: Discussionmentioning

confidence: 99%

Epicardium-Derived Tbx18+ CDCs Transplantation Improve Heart Function in Infarcted Mice

Guo

Geng

Qin

et al. 2022

Front. Cardiovasc. Med.

View full text Add to dashboard Cite

show abstract

“…It was also noted that MSCs combined with CM tend to repair the damaged lung tissues, which inhibit the disease’s progression [ 67 ]. Several experimental studies performed with CM have confirmed that it is safe for therapeutic use [ 7 , 68 , 69 ]. In our work, we performed an acute toxicity study using a single subcutaneous administration of 1 mg/kg of CM-ADSCs in Sprague Dawley rats without any adverse effects [ 56 ].…”

Section: Conditioned Medium In Pulmonary Fibrosismentioning

confidence: 99%

Mesenchyme Stem Cell-Derived Conditioned Medium as a Potential Therapeutic Tool in Idiopathic Pulmonary Fibrosis

Kolios

Paspaliaris²

2022

Biomedicines

View full text Add to dashboard Cite

Mesenchyme Stem Cells (MSCs) are the most used types of stem cells in regenerative medicine. Regenerative medicine is a rapidly emerging medicine section that creates new methods to regrow, restore, and replace diseased and damaged tissues, organs, and cells. Scholars have shown a positive correlation between MSCs-based therapies and successful treatment of diseases like cardiac ischemia, cartilage problems, bone diseases, diabetes, and even neurological disorders. Although MSCs have several varying features that make them unique, their immuno-regulatory effects in tissue repair emerge from their secretion of paracrine growth factors, exosomes, and cytokines. These cells secrete a secretome, which has regenerative and reparative properties that lead to injury amelioration, immune modulation, or fibrosis reduction. Recent studies have shown that the administration MCSs derived conditioned medium (MSCs-CM) in acute doses in humans is safe and well-tolerated. Studies from animal models and human clinical trials have also shown that they are efficacious tools in regenerative medicine. In this review, we will explore the therapeutic potential of MSCs-CM in pulmonary fibrosis, with further insight into the treatment of Idiopathic Pulmonary Fibrosis (IPF).

show abstract

Conditioned medium from a human adipose-derived stem cell line ameliorates inflammation and fibrosis in a lung experimental model of idiopathic pulmonary fibrosis

et al. 2021

View full text Add to dashboard Cite

Safety and efficacy of global intracoronary administration of cardiosphere-derived cells or conditioned medium immediately after coronary reperfusion in rats

Cited by 3 publications

References 38 publications

Epicardium-Derived Tbx18+ CDCs Transplantation Improve Heart Function in Infarcted Mice

Epicardium-Derived Tbx18+ CDCs Transplantation Improve Heart Function in Infarcted Mice

Mesenchyme Stem Cell-Derived Conditioned Medium as a Potential Therapeutic Tool in Idiopathic Pulmonary Fibrosis

Conditioned medium from a human adipose-derived stem cell line ameliorates inflammation and fibrosis in a lung experimental model of idiopathic pulmonary fibrosis

Contact Info

Product

Resources

About