Safety assessment of green tea based beverages and dried green tea extracts as nutritional supplements

Green tea as a safe alternative approach for nonalcoholic fatty liver treatment: A systematic review and meta‐analysis of clinical trials

“…Green tea is totally safe, and serious adverse effects were not reported among the studies included. Although it was reported that sometimes green tea consumption has been related with hepatotoxicity in predisposed individuals, such events have not been observed in control trials, nor among Japanese people, who historically have shown very high consumption of green tea infusions (Dekant, Fujii, Shibata, Morita, & Shimotoyodome, ). However, overconsumption of green tea can be harmful due to its caffeine content and the presence of aluminum, which can accumulate in plants and affect the bioavailability of iron.…”

“…So green tea consumption in patients with anemia, major cardiovascular problem, and renal failure should be prescribed with caution (Chacko, Thambi, Kuttan, & Nishigaki, ; Pastoriza, Mesías, Cabrera, & Rufian‐Henares, ). The safety of green tea supplementation was investigated by the Norwegian Institute of Public Health, and it recommended that green tea supplementation up to 1,944 mg/day does not lead to adverse effects (Dekant et al, ).…”

Toxicological effects of Camellia sinensis (green tea): A review

“…Genetic factors (Javaid & Bonkovsky, ), coadministration with some drugs (progesterone, contraceptives; Gallo et al, ; Jimenez‐Saenz & Martinez‐Sanchez, ; Molinari et al, ), doses (Bunchorntavakul & Reddy, ; Murakami, ), smoking (G. Yang et al, ), and tea temperature while drinking (D. Wang, Meng, et al, ) are items that might influenced on the beneficial or detrimental effects of GT consumption on health (Tables and ). Based on hepatotoxic effects, the consumption of nutritional supplements containing GT is safe up to 300 mg EGCG/person/day (Dekant, Fujii, Shibata, Morita, & Shimotoyodome, ).…”

Bioinformatics analysis of microarray profiling identifies the mechanism of focal adhesion kinase signalling pathway in proliferation and apoptosis of breast cancer cells modulated by green tea polyphenol epigallocatechin 3-gallate

“…detected there were about 1402 mg/l catechins in green tea, and the concentration of EGCG was approximately 980 mg/l while EGC was about 6.0 mg/l in green tea. Some studies compiled the statistics that intake of EGCG with green tea infusions or beverages is up to about 450 mg EGCG/person/day in Europe and higher in Asia …”

“…Some studies compiled the statistics that intake of EGCG with green tea infusions or beverages is up to about 450 mg EGCG/person/ day in Europe and higher in Asia. [13] As for the link between green tea consumption and cancer risk, there was disagreement. Hou et al analysed researches on gastric cancer; the relative risks or odds ratio of gastric cancer for the highest level of green tea consumption was compared, and seven studies suggested no association, eight researches suggested an inverse association, and one suggested a positive association.…”