Safety evaluation of continuous administration of a high dose of Valeriana fauriei root extract in mice and in humans through an open‐label study
Misato Ota,
Yuki Oiwa,
Yasuhito Maki
et al.
Abstract:AimThis study aimed to clarify the safety of Valeriana fauriei root (VF) ethanol extract through in vivo and clinical trials.MethodsMice were divided into VF and control groups. They were given VF (4 g VF/kg/day) or the vehicle mixed in the powdered food for four weeks. Food consumption and body weight changes were evaluated, and blood biochemistry and organ weights were assessed on the last day. In addition, an open‐label study was conducted on healthy subjects who took VF capsules (10 g VF/body/day) for four… Show more
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