Saffron as a Neuroprotective Agent

Namgyal, Dhondup; Sarwat, Maryam

doi:10.1016/b978-0-12-818462-2.00008-5

Cited by 6 publications

(4 citation statements)

References 43 publications

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“…Figure 7 shows the effects of POE against carrageenan-induced redox imbalance. The inflammatory stimulus doubled the NO levels compared to the control and tripled the augmentation [27,28].…”

Section: Effect Of Poe On the Inflammatory And Oxidative Mediatorsmentioning

confidence: 89%

“…Oxidative and nitrosative stress in tissue is a key parameter in carrageenan paw inflammation [26]. NO is a crucial mediator in the first and second phase of carrageenaninduced rat paw inflammation, which contributes to edema progression and hyperalgesia augmentation [27,28]. Figure 7 shows the effects of POE against carrageenan-induced redox imbalance.…”

Section: Effect Of Poe On the Inflammatory And Oxidative Mediatorsmentioning

confidence: 99%

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Efficacy of Posidonia oceanica Extract against Inflammatory Pain: In Vivo Studies in Mice

et al. 2021

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Posidonia oceanica (L.) Delile is traditionally used for its beneficial properties. Recently, promising antioxidant and anti-inflammatory biological properties emerged through studying the in vitro activity of the ethanolic leaves extract (POE). The present study aims to investigate the anti-inflammatory and analgesic role of POE in mice. Inflammatory pain was modeled in CD-1 mice by the intraplantar injection of carrageenan, interleukin IL-1β and formalin. Pain threshold was measured by von Frey and paw pressure tests. Nociceptive pain was studied by the hot-plate test. POE (10–100 mg kg−1) was administered per os. The paw soft tissue of carrageenan-treated animals was analyzed to measure anti-inflammatory and antioxidant effects. POE exerted a dose-dependent, acute anti-inflammatory effect able to counteract carrageenan-induced pain and paw oedema. Similar anti-hyperalgesic and anti-allodynic results were obtained when inflammation was induced by IL-1β. In the formalin test, the pre-treatment with POE significantly reduced the nocifensive behavior. Moreover, POE was able to evoke an analgesic effect in naïve animals. Ex vivo, POE reduced the myeloperoxidase activity as well as TNF-α and IL-1β levels; further antioxidant properties were highlighted as a reduction in NO concentration. POE is the candidate for a new valid strategy against inflammation and pain.

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Section: Effect Of Poe On the Inflammatory And Oxidative Mediatorsmentioning

confidence: 89%

Section: Effect Of Poe On the Inflammatory And Oxidative Mediatorsmentioning

confidence: 99%

Efficacy of Posidonia oceanica Extract against Inflammatory Pain: In Vivo Studies in Mice

et al. 2021

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“…Though the advancements in the medical field have increased the lifespan of human beings, the occurrence of age-related neurodegenerative diseases and dementia-related illnesses have increased from 4.0% in 1990 to 8.2% in 2019 [ 1 ] Depressive disorders (33.8%) and anxiety disorders (19%) are the major contributors to mental illness affecting close to about 197.3 million people (~14.3%) [ 2 ]. Several factors including daily light/dark cycle, diet, physical exercise, heavy metal toxicity, and social stress regulate neurodegeneration in both central and peripheral nervous systems, but oxidative stress and neuroinflammations are major causes of neurodegeneration [ 3 , 4 , 5 , 6 , 7 , 8 ]. In most neurodegenerative disorders, these two processes occur simultaneously and coexist [ 9 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

Curcumin Ameliorates the Cd-Induced Anxiety-like Behavior in Mice by Regulating Oxidative Stress and Neuro-Inflammatory Proteins in the Prefrontal Cortex Region of the Brain

Namgyal

Ali

Hussain³

et al. 2021

Antioxidants

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Age-related neurodegenerative diseases and vascular dementia are major challenges to the modern health care system. Most neurodegenerative diseases are associated with impaired spatial working memory and anxiety-like behavior. Thus, it is important to understand the underlying cellular mechanisms of neurodegenerative diseases in different regions of the brain to develop an effective therapeutic approach. In our previous research paper, we have reported the ameliorative effect of curcumin in Cd-induced hippocampal neurodegeneration. However, recently many researchers had reported the important role of the prefrontal cortex in higher cognitive functions. Therefore, to look into the cellular mechanism of curcumin protection against Cd-induced prefrontal cortex neurotoxicity, we investigated spatial working memory, anxiety-like behavior and analyzed prefrontal cortex inflammatory markers (IL-6, IL-10, and TNFα), antioxidant enzymes (SOD, GSH, and CAT), and pro-oxidant MDA level. Further, we conducted histological studies of the prefrontal cortex in Swiss albino mice exposed to cadmium (2.5 mg/kg). We observed that curcumin treatment improved the spatial working memory and anxiety-like behavior of mice through reduction of prefrontal cortex neuroinflammation and oxidative stress as well as increasing the number of viable prefrontal cortex neuronal cells. Our result suggests that environmental heavy metal cadmium can induce behavioral impairment in mice through prefrontal cortex cellular inflammation and oxidative stress. We found that curcumin has a potential therapeutic property to mitigate these behavioral and biochemical impairments induced by cadmium.

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“…The role of plant-derived herbal drugs in mental health has been extensively explored in the past [ 26 ]. In current research work, we tried to monitor the deleterious consequences of aberrant lighting on the emotional and metabolic profile of mice by administering curcumin.…”

Section: Introductionmentioning

confidence: 99%

Aberrant Lighting Causes Anxiety-like Behavior in Mice but Curcumin Ameliorates the Symptoms

Namgyal

Chandan

Ali

et al. 2021

Animals

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In the modern research field, laboratory animals are constantly kept under artificial lighting conditions. However, recent studies have shown the effect of artificial light on animal behavior and metabolism. In the present study on mice, following three weeks of housing in dim light at night (dLAN; 5lux) and complete darkness (DD; 0lux), we monitored the effect on body weight, daily food intake, anxiety-like behavior by employing the open field test, and expression of the period (PER1) gene. We also studied the effect of oral administration of different concentrations of curcumin (50, 100, and 150 mg/kg) for three weeks in the same mice and monitored these parameters. The exposure to dLAN had significantly increased the anxiety-like behavior and body weight possibly through the altered metabolism in mice, whereas exposure to DD caused increased anxiety but no significant difference in weight gain. Moreover, the expression of the PER1 gene involved in sleep was also found to be decreased in the aberrant light conditions (dLAN and DD). Although the treatment of curcumin had no effect on body weight, it ameliorated the anxiety-like behavior possibly by modulating the expression of the PER1 gene. Thus, alteration in the light/dark cycle had a negative effect on laboratory animals on the body weight and emotions of animals. The present study identifies the risk factors associated with artificial lighting systems on the behavior of laboratory animals and the ameliorative effects of curcumin, with a focus on anxiety-like behavior.

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Saffron as a Neuroprotective Agent

Cited by 6 publications

References 43 publications

Efficacy of Posidonia oceanica Extract against Inflammatory Pain: In Vivo Studies in Mice

Efficacy of Posidonia oceanica Extract against Inflammatory Pain: In Vivo Studies in Mice

Curcumin Ameliorates the Cd-Induced Anxiety-like Behavior in Mice by Regulating Oxidative Stress and Neuro-Inflammatory Proteins in the Prefrontal Cortex Region of the Brain

Aberrant Lighting Causes Anxiety-like Behavior in Mice but Curcumin Ameliorates the Symptoms

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