Intraseasonal and interannual variability of rainfall is simulated using the International Centre for Theoretical Physics (ICTP) Regional Climate Model (RegCM3) over West Africa. The intraseasonal variability of rainfall showing three distinct phases and the monsoon jump is well reproduced in the simulation. In addition, the regional model shows that while the monsoon rainbelt moves to the Sahel, the African Easterly Jet (AEJ) undergoes a northward migration and a weakening from June to August, when the core is at its northernmost location. This coexists with the appearance and the strengthening of the Tropical Easterly Jet (TEJ), the development and increased activity of the African Easterly Waves (AEWs), and the intensification and northward shift of the ascent between the AEJ and the TEJ core levels and axis. Similarly, the simulated interannual variability of rainfall over West Africa, the Guinea region, and the Sahel, as well as the variability of atmospheric features during contrasting wet and dry years, is also well captured. In fact, in the simulation during dry years the AEWs activity is decreased while the AEJ is strengthened and migrates southward, the TEJ becomes weaker, and the ascent between the levels of the AEJ and the TEJ decreases. The simulated rainfall variability and the behavior of the related features during the rainy season and during contrasting wet and dry years are in line with previous studies that used observations and reanalysis. We conclude that this model performance is of sufficient quality for application to the study of climate processes and mechanisms over West Africa.