2024
DOI: 10.21203/rs.3.rs-3798644/v1
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Saikogenin A improves ethanol-induced liver injury by targeting SIRT1 to modulate lipid metabolism

Yufeng Wang,
Ming-zhu Jiang,
Ying Feng
et al.

Abstract: Chronic alcohol consumption leads to a spectrum of liver disorders, including steatosis, inflammation, and fibrosis, collectively known as alcohol liver disease (ALD). Steatosis is a critical hallmark of ALD, making it an important target for therapeutic intervention. Saikosaponin A (SSa), a compound found in Radix Bupleuri, has previously shown promising hepatoprotective, anti-inflammatory, and antioxidant properties. However, its role in ALD remains understudied, with direct regulatory targets and mechanisms… Show more

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