Sakharosnizhayushchie sul'fanilamidy i ?ishemicheskiy porog? serdtsa u bol'nykh sakharnym diabetom tipa 2 s koronarnoy bolezn'yu serdtsa

Александров, А. А.; Bondarenko, Irina Ziyatovna; Kukharenko, Svetlana Semenovna; Yadrikhinskaya, M N; Вилков, В. Г.; Ахматова, Ф. Д.; Aleksandrova, V K; Артамонова, Н. В.; Соловьева, О. Э.; Дедов, И И

doi:10.14341/dm2002418-22

Cited by 1 publication

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“…With the current variety of antimicrobial drugs, sulfonamides [ 7 , 8 , 9 ], which are used in medicine [ 10 , 11 , 12 , 13 ] and veterinary medicine, still play an important role in the fight against and prevention of various types of infections, having antibacterial, hypoglycemic and other types of biological activity. Despite the diverse number of new antibacterial agents, sulfonamides are regularly prescribed for the treatment of various infectious diseases, type 2 diabetes mellitus [ 7 , 14 , 15 , 16 , 17 ] and urinary tract infections [ 18 ] and for first aid, using napkins from hemostatic collagen plates in combination with zeolite powder and antibacterial drugs [ 19 ]. Typical representatives of sulfonamides are sulfanilamide, sulfacyl sodium, urosulfan, sulgin, norsulfazol, phthalazol, etazol, sulfadimezin, sulfapyridazine, sulfamonomethoxine, sulfadimethoxine, sulfalene and saladosin.…”

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confidence: 99%

Nature of Luminescence and Pharmacological Activity of Sulfaguanidine

et al. 2023

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Sulfonamides are one of the oldest groups of veterinary chemotherapeutic agents. Physico-chemical properties, the concentration and the nature of the environment are the factors responsible for the distribution of sulfonamides in the living organism. Although these drug compounds have been in use for more than half a century, knowledge about their behavior is still limited. Physiological activity is currently attributed to the sulfanyl radical. Our study is devoted to the spectral properties of aqueous solutions of sulfaguanidine, in which the formation of complexes with an H-bond and a protonated form takes place. The nature of the fluorescent state of sulfaguanidine was interpreted using computational chemistry, the electronic absorption method and the luminescence method. The structure of sulfaguanidine includes several active fragments: aniline, sulfonic and guanidine. To reveal the role of fragments in the physiological activity of the studied antibiotic, we calculated and compared the effective charges of the fragments of aniline and sulfaguanidine molecules. Chromophore groups were identified in molecules, which determine the intermolecular interaction between a molecule and a proton-donor solvent. The study also revealed the impact of sulfone and guanidine groups, as well as complexation, on the effective charge of the antibiotic fragment responsible for physiological activity and luminescent ability.

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