Salamander models for elucidating mechanisms of developmental biology, evolution, and regeneration: Part one

McCusker, Catherine; Monaghan, James R.; Whited, Jessica L.

doi:10.1002/dvdy.358

Cited by 1 publication

(2 citation statements)

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“…Although multiple animals have limited capabilities to regenerate, the axolotl has devised unique, extensive, and elegant methods of regenerating multiple tissues (Table 1). [111][112][113] Here, we will focus on a subset of regeneration studies that span both historical and current work. Neoteny places axolotls at a unique intersection of developmental and regenerative research potential.…”

Section: The Ultimate Regeneratormentioning

confidence: 99%

“…79 Apoptotic tissue degradation is a precursor to the regenerative process following axolotl limb injuries, and an axolotl must remove injured cells and reduce immune cell counts to a specific balance to avoid unwanted damage. 120 There are multiple in-depth recent reviews on the subject of axolotl regeneration, 112,113,121,122 but the current body of research suggests that salamanders respond to injury signals in a way that is distinct from mammals. One of the secrets to axolotl limb and tail regeneration lies in its ability to form a blastema after injury.…”

Section: The Ultimate Regeneratormentioning

confidence: 99%

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The amazing and anomalous axolotls as scientific models

Adamson

Morrison-Welch

Rogers

2022

Developmental Dynamics

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Ambystoma mexicanum (axolotl) embryos and juveniles have been used as model organisms for developmental and regenerative research for many years. This neotenic aquatic species maintains the unique capability to regenerate most, if not all, of its tissues well into adulthood. With large externally developing embryos, axolotls were one of the original model species for developmental biology. However, increased access to, and use of, organisms with sequenced and annotated genomes, such as Xenopus laevis and tropicalis and Danio rerio, reduced the prevalence of axolotls as models in embryogenesis studies. Recent sequencing of the large axolotl genome opens up new possibilities for defining the recipes that drive the formation and regeneration of tissues like the limbs and spinal cord. However, to decode the large A. mexicanum genome will take a herculean effort, community resources, and the development of novel techniques. Here, we provide an updated axolotl‐staging chart ranging from one‐cell stage to immature adult, paired with a perspective on both historical and current axolotl research that spans from their use in early studies of development to the recent cutting‐edge research, employment of transgenesis, high‐resolution imaging, and study of mechanisms deployed in regeneration.

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Section: The Ultimate Regeneratormentioning

confidence: 99%