SALDI-MS Signal enhancement using oxidized graphitized carbon black nanoparticles

Amini, Nahid; Shariatgorji, Mohammadreza; Thorsén, Gunnar

doi:10.1016/j.jasms.2009.02.017

Cited by 54 publications

(36 citation statements)

References 28 publications

(31 reference statements)

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“…Amini, Shariatgorji, and Thorsén () compared the sensitivity of non‐oxidized graphitized carbon black (GCB)‐NPs and oxidized GCB‐NPs for the detection of various pharmaceuticals. Oxidized GCB‐NPs contain more carboxylic acid groups in comparison to non‐oxidized GCB‐NPs and those acidic groups were found to increase the sensitivity of the analysis of small molecule pharmaceuticals including carbamazepine, propranolol, sulfaphenazole, sulfadimethoxine, tetraethylethylenediphosphonate, triphenylphosphate, dihydroxy‐streptomycine and tobranmycine.…”

Section: Carbon‐based Saldi‐msmentioning

confidence: 99%

Surface‐assisted laser desorption ionization mass spectrometry techniques for application in forensics

Guinan

Kirkbride

Pigou

et al. 2014

Mass Spectrometry Reviews

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Matrix-assisted laser desorption ionization (MALDI) mass spectrometry (MS) is an excellent analytical technique for the rapid and sensitive analysis of macromolecules (>700 Da), such as peptides, proteins, nucleic acids, and synthetic polymers. However, the detection of smaller organic molecules with masses below 700 Da using MALDI-MS is challenging due to the appearance of matrix adducts and matrix fragment peaks in the same spectral range. Recently, nanostructured substrates have been developed that facilitate matrix-free laser desorption ionization (LDI), contributing to an emerging analytical paradigm referred to as surface-assisted laser desorption ionization (SALDI) MS. Since SALDI enables the detection of small organic molecules, it is rapidly growing in popularity, including in the field of forensics. At the same time, SALDI also holds significant potential as a high throughput analytical tool in roadside, work place and athlete drug testing. In this review, we discuss recent advances in SALDI techniques such as desorption ionization on porous silicon (DIOS), nano-initiator mass spectrometry (NIMS) and nano assisted laser desorption ionization (NALDI™) and compare their strengths and weaknesses with particular focus on forensic applications. These include the detection of illicit drug molecules and their metabolites in biological matrices and small molecule detection from forensic samples including banknotes and fingerprints. Finally, the review highlights recent advances in mass spectrometry imaging (MSI) using SALDI techniques.

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Section: Carbon‐based Saldi‐msmentioning

confidence: 99%

Surface‐assisted laser desorption ionization mass spectrometry techniques for application in forensics

Guinan

Kirkbride

Pigou

et al. 2014

Mass Spectrometry Reviews

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show abstract

“…62 The surface of oxidized GCB contains more carboxylic acid groups than non-oxidized GCB; these carboxylic acid groups enhance the efficiency of the desorption/ionization process of relatively more hydrophobic compounds. Kawasaki et al employed an oxidized, pyrolytic, highly oriented graphite polymer film with a SALDI film for an environmental analysis of low-mass analytes.…”

Section: ·4 Carbon-based Substratesmentioning

confidence: 99%

Functionalized Nanoparticles and Nanostructured Surfaces for Surface-Assisted Laser Desorption/Ionization Mass Spectrometry

2010

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“…69 Amini et al employed oxidized graphitized carbon black (GCB) particles for the analysis of pharmaceutical compounds. 70 The advantages of using GCB materials rather than CNTs are their low cost and greater content of carboxylic acid groups on their surface, thereby enhancing the efficiency of the ionization process and the desorption of hydrophobic compounds.…”

Section: Other Analytesmentioning

confidence: 99%

Analysis of Biomolecules through Surface‐Assisted Laser, Desorption/Ionization Mass Spectrometry Employing Nanomaterials

Chen

Tomalová

Preisler

2011

J Chinese Chemical Soc

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Nanomaterials, primarily nanoparticles (NPs), can serve as an alternative matrix for the analysis of various biomolecules through surface-assisted laser desorption/ionization mass spectrometry (SALDI MS). SALDI MS has been developed to overcome poor reproducibility and high background in the lowmass region commonly occurring in matrix-assisted laser desorption/ionization mass spectrometry (MALDI MS). Various nanomaterials, unmodified or functionalized with recognition ligands, can have a strong affinity toward certain analytes and thus are applicable for their concentration and enrichment from complex biological matrices. In mass spectrometry imaging (MSI), the use of NPs instead of the conventional matrices can improve the spatial resolution up to the cellular level. In this review, the nature of NPs, the methods of sample preparation and approaches for quantitation of biomolecules through SALDI MS are discussed. Practical applications and limitations of SALDI MS employing NPs for separate samples and MSI are mentioned. With regard to the nature of MSI analysis, the use of nanostructured surfaces for MSI is also reflected in this review.

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SALDI-MS Signal enhancement using oxidized graphitized carbon black nanoparticles

Cited by 54 publications

References 28 publications

Surface‐assisted laser desorption ionization mass spectrometry techniques for application in forensics

Surface‐assisted laser desorption ionization mass spectrometry techniques for application in forensics

Functionalized Nanoparticles and Nanostructured Surfaces for Surface-Assisted Laser Desorption/Ionization Mass Spectrometry

Analysis of Biomolecules through Surface‐Assisted Laser, Desorption/Ionization Mass Spectrometry Employing Nanomaterials

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