Salen- Manganese Complexes: Combined Superoxide Dismutase/Catalase Mimics with Broad Pharmacological Efficacy

Catalytic Activity for Decomposition of Hydrogen Peroxide by Metal Complexes of Water-Soluble Thiacalix[4]arenetetrasulfonate on the Modified Anion-Exchangers

“…4) Accordingly, much effort has been focused on developing efficient catalase mimics which exhibit high catalytic activity.…”

“…[10][11][12][13] Because of these features, some thiacalix[n]-arene derivatives have been used as an analytical reagent for the separation of various metal ions. 6,8) Moreover, we have recently demonstrated that some metal complexes of thiacalix [4]arenetetrasulfonate on modified anion-exchangers exhibit high peroxidase-like catalytic activity, and are useful not only for the determination of H 2 O 2 but also for the determination of glucose in control serum as a mimesis of peroxidase in clinical analyses. 14,15) Accordingly, in this study, the catalase-like catalytic activity of metal complexes of thiacalix [4]arenetetrasulfonate on modified anion-exchangers was investigated.…”

“…6,8) Moreover, we have recently demonstrated that some metal complexes of thiacalix [4]arenetetrasulfonate on modified anion-exchangers exhibit high peroxidase-like catalytic activity, and are useful not only for the determination of H 2 O 2 but also for the determination of glucose in control serum as a mimesis of peroxidase in clinical analyses. 14,15) Accordingly, in this study, the catalase-like catalytic activity of metal complexes of thiacalix [4]arenetetrasulfonate on modified anion-exchangers was investigated. To the best of our knowledge, no report has been published on the catalaselike catalytic activity of metal complexes of thiacalix[n]-arenes and calix[n]arenes.…”

“…To the best of our knowledge, no report has been published on the catalaselike catalytic activity of metal complexes of thiacalix[n]-arenes and calix[n]arenes. Any metal complex of thiacalix [4]arenes with high catalase-like catalytic activity would be useful not only as a catalase mimic but also as an analytical reagent in clinical analyses.…”

The in vitro effects of superoxide, some commercially available antioxidants and red palm oil on sperm motility

“…Although redox active metals such as Fe(II) can accelerate LPO, ionic Mn (10-100 mmol L -1 ) has been shown to inhibit LPO in rat liver microsomes [34]. In addition, several known Mn complexes including the Mn salen and Mn bis(cyclohexylpyridine)-substituted macro cyclic ligand have shown promise as a possible SOD mimic [35][36][37]. Studies have shown that these complexes are as effective as SOD enzymes in detoxifying superoxide under some experimental conditions [38].…”