2018
DOI: 10.3892/ol.2018.8090
|View full text |Cite
|
Sign up to set email alerts
|

Salidroside induces apoptosis in human ovarian cancer SKOV3 and A2780 cells through the p53 signaling pathway

Abstract: Abstract. Salidroside is one of the most potent compounds extracted from the plant Rhodiola rosea, and its cardiovascular protective effects have been studied extensively. However, the role of salidroside in human ovarian carcinoma remains unknown. The aim of the current study was to investigate the effects of salidroside on the proliferation and apoptosis of SKOV3 and A2780 cells using MTT assay and acridine orange/ethidium bromide staining. Salidroside activated caspase-3 and upregulated the levels of apopto… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1
1

Citation Types

0
22
0

Year Published

2018
2018
2023
2023

Publication Types

Select...
8

Relationship

0
8

Authors

Journals

citations
Cited by 18 publications
(22 citation statements)
references
References 38 publications
0
22
0
Order By: Relevance
“…The Wnt signaling pathway, related to the occurrence, proliferation, invasion, and transference of tumors, has great potential as both a marker for tumor diagnosis and target for cancer treatments . Besides, other pathways, such as the P53 signaling pathway, are also highly connected with tumor development . Therefore, in order to verify these bioinformatics analysis results, we further assessed relevant cell cycle signaling pathways to determine their connection with GINS2.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…The Wnt signaling pathway, related to the occurrence, proliferation, invasion, and transference of tumors, has great potential as both a marker for tumor diagnosis and target for cancer treatments . Besides, other pathways, such as the P53 signaling pathway, are also highly connected with tumor development . Therefore, in order to verify these bioinformatics analysis results, we further assessed relevant cell cycle signaling pathways to determine their connection with GINS2.…”
Section: Discussionmentioning
confidence: 99%
“…36,37 Besides, other pathways, such as the P53 signaling pathway, are also highly connected with tumor development. 38,39 Therefore, in order to verify these bioinformatics analysis results, we further assessed relevant cell cycle signaling pathways to determine their connection with GINS2. Generally, the GINS2 gene and MCM2 molecule jointly participate in the DNA replication process as a "minimum complex".…”
Section: Discussionmentioning
confidence: 99%
“…The initiation of mitochondria-mediated apoptotic pathway by caspase-9 resulting in executing apoptosis by caspase-3 [38]. Hence, we detected the caspase-3 and caspase-9 activity using Caspase Activity Assay Kits to further explore the mechanism of apoptosis [39,40]. Figure 4a reveals the changes of caspase-3 activity in MC38 cells after exposing to BAE with different ANC concentrations for 48 h. The activity of caspase-3 increased to 132.5 ± 2.3%, 155.1 ± 3.6%, 169.4 ± 2.3% and 764.5 ± 3.0% for ANC doses of 100, 200, 500, and 1000 μM compared with the control, respectively.…”
Section: Activation Of Caspasesmentioning
confidence: 99%
“…As one of the biologically active ingredients of the root of Rhodiola rosea, salidroside (SAL) has been used as a novel anti-inflammatory agent [11,12], free radical scavenger to inhibit oxidative stress [13], and antiapoptotic agent [14]. As one of the biologically active ingredients of the root of Rhodiola rosea, salidroside (SAL) has been used as a novel anti-inflammatory agent [11,12], free radical scavenger to inhibit oxidative stress [13], and antiapoptotic agent [14].…”
Section: Introductionmentioning
confidence: 99%