Saline irrigation for reducing the recurrence of common bile duct stones after lithotripsy: a randomized controlled trial

Lin, Yanyan; Yang, Man; Cao, Jie; Zhang, Xianzhuo; Mi, Ningning; Xiao, Yang; Wang, Haiping; Long, Gui‐Lu; Bai, Mingzhen; Fu, Wenkang; Li, Xun; Yue, Ping; Yuan, Jinqiu; Meng, Wenbo; Leung, Joseph

doi:10.1016/j.eclinm.2023.101978

Cited by 3 publications

(1 citation statement)

References 30 publications

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“…In clinics, during endoscopic lithotomy, saline irrigation after mechanical lithotripsy has been demonstrated to be effective in reducing the recurrence rate of common bile duct stones, possibly by cleaning stone fragments [ 97 ]. In an animal model with chronic proliferative cholangitis, antibiotic irrigation effectively decreased the quantity of residual Escherichia coli in the biliary system and reduced the concentration of LPS and the expression of monocyte chemoattractant protein-1 (MCP1), cluster of differentiation 14 (CD14), cyclooxygenase-2, protein kinase C (PKC), Nuclear factor Kappa beta, C-myc, Interleukin(IL)-6, TNF-α, transforming growth factor-β1, β-glucuronidase, and MUC5AC [ 84 ].…”

Section: Bacterial Infections and Inflammationmentioning

confidence: 99%

Role of Secretory Mucins in the Occurrence and Development of Cholelithiasis

Zhao,

Yang,

et al. 2024

Biomolecules

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Cholelithiasis is a common biliary tract disease. However, the exact mechanism underlying gallstone formation remains unclear. Mucin plays a vital role in the nuclear formation and growth of cholesterol and pigment stones. Excessive mucin secretion can result in cholestasis and decreased gallbladder activity, further facilitating stone formation and growth. Moreover, gallstones may result in inflammation and the secretion of inflammatory factors, which can further increase mucin expression and secretion to promote the growth of gallstones. This review systematically summarises and analyses the role of mucins in gallstone occurrence and development and its related mechanisms to explore new ideas for interventions in stone formation or recurrence.

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Section: Bacterial Infections and Inflammationmentioning

confidence: 99%

Role of Secretory Mucins in the Occurrence and Development of Cholelithiasis

Zhao,

Yang,

et al. 2024

Biomolecules

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Digital cholangioscopy-assisted, direct visualization-guided, radiation-free, endoscopic retrograde intervention for cholelithiasis: technical feasibility, efficacy, and safety

Feng,

Liang,

Liu

et al. 2024

Surg Endosc

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Structural or functional abnormality of sphincter of Oddi: an important factor for the recurrence of choledocholithiasis after endoscopic treatment

Yang,

Zhao,

et al. 2024

Annals of Medicine

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A high recurrence rate is undesirable after treatment of common bile duct (CBD) stones. A major risk factor identified for recurrence is that invasive techniques, including surgical or endoscopic treatments, will impair the biliary tract system either by direct incision of the CBD or by cutting or dilating the ampulla of Vater. During endoscopic treatment, two main assisted methods for lithotomy, sphincterotomy and papillary balloon dilation, can result in different degrees of damage to the structure and function of the sphincter of Oddi (SO), contributing to slowing of biliary excretion, cholestasis, biliary bacterial infection, and promotion of bile duct stone recurrence. In this review, the relationship between endoscopic lithotomy and structural impairment or functional abnormality of the SO will be summarized, and their relationship with the recurrence of CBD stones will also be analyzed. Further improvement of these endoscopic methods or exploration of some novel methods, such as endoscopic endoclip papilloplasty, temporary insertion of a self-expandable metal stent, and combined application of peroral cholangioscopy, may aid in providing more appropriate treatment for patients with choledocholithiasis, repair or protect the function and structure of SO, reduce or prevent the recurrence of bile duct stones, and improve patient outcomes.

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Saline irrigation for reducing the recurrence of common bile duct stones after lithotripsy: a randomized controlled trial

Cited by 3 publications

References 30 publications

Role of Secretory Mucins in the Occurrence and Development of Cholelithiasis

Role of Secretory Mucins in the Occurrence and Development of Cholelithiasis

Digital cholangioscopy-assisted, direct visualization-guided, radiation-free, endoscopic retrograde intervention for cholelithiasis: technical feasibility, efficacy, and safety

Structural or functional abnormality of sphincter of Oddi: an important factor for the recurrence of choledocholithiasis after endoscopic treatment

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