Saliva: A Diagnostic Marker in Health and Disease

Garewal, Ripin

doi:10.55162/mcds.01.002

Cited by 1 publication

(1 citation statement)

References 14 publications

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“…It is possible to study DNA, mRNA or inflammatory cytokines through RT-PCR or Elisa. Moreover, proteins and peptides can be quantified with many biochemical techniques such as capillary electrophoresis, gel electrophoresis, magnetic resonance, liquid chromatography and immunoassay tests [ 111 ]. Commercial Elisa kits have good sensitivity, but they have a long data processing; now, the development of biosensors allows quicker and easier protocol: these are specific devices able to convert biological markers into measurable signal, as explained in Figure 3 [ 7 ].…”

Section: Discussionmentioning

confidence: 99%

The New Era of Salivaomics in Dentistry: Frontiers and Facts in the Early Diagnosis and Prevention of Oral Diseases and Cancer

et al. 2022

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Nowadays, with the development of new and highly sensitive, blood is not the only medium of choice for the diagnosis of several diseases and pathological conditions. Saliva is now considered a safe and non-invasive sample to study oral and systemic diseases, showing great diagnostic potential. According to several recent studies, saliva has emerged as an emerging biofluid for the early diagnosis of several diseases, indicated as a mirror of oral and systemic health and a valuable source of clinically relevant information. Indeed, several studies have observed that saliva is useful for detecting and diagnosing malignant tumours, human immunodeficiency virus, heart disease, and autoimmune diseases. The growing realisation that saliva is an inexhaustible source of information has led to the coining of the term ‘Salivaomics’, which includes five “omics” in connection with the main constituents of saliva: genome and epigenome, transcriptomics, metabolomics, lipidomics, proteomics and microbiota. All those may be changed by disease state, so they offer significant advantages in the early diagnosis and prognosis of oral diseases. The aim of the present review isto update and highlight the new frontiers of salivaomics in diagnosing and managing oral disorders, such as periodontitis, premalignant disorders, and oral squamous cell carcinoma (OSCC).

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Section: Discussionmentioning

confidence: 99%