Saliva as a diagnostic tool for oral and systemic diseases

Javaid, Muhammad; Ahmed, Ahad S.; Durand, Robert; Tran, Simon D.

doi:10.1016/j.jobcr.2015.08.006

Cited by 309 publications

(262 citation statements)

References 62 publications

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“…These include innovative measures for non-invasive HIV testing, such as the use of oral saliva testing methodology. 23,24 Meticulous planning for logistics and resources to handle such outbreaks would pay dividends, as shown by a study from Guinea, where an efficient TB health programme was maintained without substantial service interruptions. 25 These lessons could be adopted to manage any future outbreaks.…”

Section: Public Health Action Ebola Outbreak and Hiv Testing In Libermentioning

confidence: 99%

Did the 2014 Ebola outbreak in Liberia affect HIV testing, linkage to care and ART initiation?

Jacobs¹,

Bhat

Owiti

et al. 2017

public health action

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Section: Public Health Action Ebola Outbreak and Hiv Testing In Libermentioning

confidence: 99%

Did the 2014 Ebola outbreak in Liberia affect HIV testing, linkage to care and ART initiation?

Jacobs¹,

Bhat

Owiti

et al. 2017

public health action

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“…Saliva is an abundant and accessible biofluid (Sivadasan et al 2015;Javaid et al 2016). However, recently, a new approach integrating both saliva and tumor tissue metabolomics will be useful in understanding the origin of salivary metabolites in oral cancer patients.…”

Section: Biomarkers For Early Cancer Detection (Table 4)mentioning

confidence: 99%

The oral cavity microbiota: between health, oral disease, and cancers of the aerodigestive tract

et al. 2017

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Many studies show that the human microbiome plays a critical role in the chronic pathologies of obesity, inflammatory bowel diseases, and diabetes. More recently, the interaction between cancer and the microbiome has been highlighted. Most studies have focused on the gut microbiota because it represents the most extensive bacterial community, and the body of evidence correlating it with gut syndromes is increasing. However, in the strict sense, the gastrointestinal (GI) tract begins in the oral cavity, and special attention should be paid to the specific flora of this cavity. This study reviewed the current knowledge about the various microbial ecosystems of the upper part of the GI tract and discussed their potential link to carcinogenesis. The overall composition of the microbial communities, as well as the presence or absence of "key species", in relation to carcinogenesis is addressed. Alterations in the oral microbiota can potentially be used to predict the risk of cancer. Molecular advances and the further monitoring of the microbiota will increase our understanding of the role of the microbiota in carcinogenesis and open new perspectives for future therapeutic and prophylactic modalities.Key words: upper aerodigestive, microbiome, oral cavity, carcinogenesis.Résumé : Plusieurs études montrent que le microbiome humain joue un rôle essentiel dans les pathologies chroniques que sont l'obésité, les maladies inflammatoires de l'intestin et le diabète. Plus récemment, l'interaction entre le cancer et le microbiome a été soulignée. La plupart des études se sont concentrées sur le microbiote intestinal car il représente la communauté bactérienne la plus étendue, et l'ensemble des preuves le corrélant avec les syndromes de l'intestin est en croissance. Cependant, au sens strict, le tractus gastro-intestinal (GI) commence dans la cavité orale et une attention spéciale devrait être portée à la flore spécifique de cette cavité. Cette étude fait la synthèse des connaissances actuelles relatives à divers écosystèmes microbiens de la partie supérieure du tractus GI et discute de leur lien potentiel à la carcinogenèse. La composition globale des communautés microbiennes, de même que la présence ou l'absence « d'espèces clés » relativement à la carcinogenèse sont soulevées. Des modifications du microbiote oral peuvent potentiellement être utilisées pour prédire les risques de cancer. Les percées moléculaires et la surveillance accrue du microbiote accroitront notre compréhension du rôle du microbiote dans la carcinogenèse et ouvriront de nouvelles perspectives en vue de modalités thérapeutiques et prophylactiques futures. [Traduit par la Rédaction]

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“…El uso de la saliva como medio para el diagnóstico se basa en que la saliva lubrica toda la cavidad bucal y por lo tanto, es más probable que represente toda la superficie expuesta y las alteraciones presentes, lo cual no ocurre utilizando el examen por medio de una biopsia invasiva del tejido local, pero ésta a su vez se enfrenta a otras dificultades como la sensibilidad en relación a la contaminación por bacterias y células del sistema inmune (19). La saliva contiene un amplio espectro de péptidos y proteínas, ácidos nucleicos, electrolitos y hormonas que se originan de múltiples fuentes tanto locales como sistémicas; estos podrían considerarse potenciales biomarcadores salivales, los cuales han mostrado correlación con la patogénesis del cáncer bucal (20).…”

Section: Diagnóstico Del Cáncer Bucalunclassified

El cáncer bucal y su relación con la proteína translocadora mitocondrial de 18kda

2017

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Saliva as a diagnostic tool for oral and systemic diseases

Cited by 309 publications

References 62 publications

Did the 2014 Ebola outbreak in Liberia affect HIV testing, linkage to care and ART initiation?

Did the 2014 Ebola outbreak in Liberia affect HIV testing, linkage to care and ART initiation?

The oral cavity microbiota: between health, oral disease, and cancers of the aerodigestive tract

El cáncer bucal y su relación con la proteína translocadora mitocondrial de 18kda

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