Saliva diagnostics: emerging techniques and biomarkers for salivaomics in cancer detection

Liu, Jieren; Huang, Dongna; Cai, Yuanzhe; Cao, Zhihua; Liu, Zhiyu; Zhang, Shuo; Zhao, Lin; Wang, Xin; Wang, Yuchuan; Huang, Feijuan; Wu, Zhengzhi

doi:10.1080/14737159.2022.2167556

Cited by 9 publications

(6 citation statements)

References 161 publications

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“…The potential for using salivary biomarkers as indicators of systemic and/or oral health status has been emphasized by recent investigations 34 , 70 , 71 and by the National Institutes of Health recommendation, so that saliva might be considered a valuable analytical biofluid, replicating, in many cases, the blood. 72 …”

Section: Discussionmentioning

confidence: 99%

Plasmon resonance biosensor for interleukin-1β point-of-care determination: A tool for early periodontitis diagnosis

Cennamo,

Bencivenga,

Annunziata

et al. 2024

iScience

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Section: Discussionmentioning

confidence: 99%

Plasmon resonance biosensor for interleukin-1β point-of-care determination: A tool for early periodontitis diagnosis

Cennamo,

Bencivenga,

Annunziata

et al. 2024

iScience

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“…indicated that multi-omics analysis of saliva explains molecular interactions and facilitates causal inference. However, saliva’s standardized collection and analysis techniques need to be further improved ( 64 ).…”

Section: Sources Of Specimens Of Microbesmentioning

confidence: 99%

“…Therefore, different collection methods are required for different sources of microbes. In addition, when performing joint multi-omics analyses, the content and type of DNA, RNA, and proteins are also closely related to the collection method ( 64 ). For example, when collecting oral microbes, individual salivary glands have fewer non-salivary components, such as shed epithelium and food debris, making them more suitable for oral multi-omics analysis.…”

Section: Current Problems With the Use Of Microbes For The Detectionmentioning

confidence: 99%

“…For example, when collecting oral microbes, individual salivary glands have fewer non-salivary components, such as shed epithelium and food debris, making them more suitable for oral multi-omics analysis. In contrast, whole salivary glands are more suitable for functional analysis of saliva ( 64 ). We need to choose the most appropriate collection method according to different samples.…”

Section: Current Problems With the Use Of Microbes For The Detectionmentioning

confidence: 99%

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Microbes for lung cancer detection: feasibility and limitations

Zhou,

Zhu,

Guo

et al. 2024

Front. Oncol.

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As the second most common cancer in the world, the development of lung cancer is closely related to factors such as heredity, environmental exposure, and lung microenvironment, etc. Early screening and diagnosis of lung cancer can be helpful for the treatment of patients. Currently, CT screening and histopathologic biopsy are widely used in the clinical detection of lung cancer, but they have many disadvantages such as false positives and invasive operations. Microbes are another genome of the human body, which has recently been shown to be closely related to chronic inflammatory, metabolic processes in the host. At the same time, they are important players in cancer development, progression, treatment, and prognosis. The use of microbes for cancer therapy has been extensively studied, however, the diagnostic role of microbes is still unclear. This review aims to summarize recent research on using microbes for lung cancer detection and present the current shortcomings of microbes in collection and detection. Finally, it also looks ahead to the clinical benefits that may accrue to patients in the future about screening and early detection.

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“…Saliva is an easily accessible body fluid with regular alterations in composition under different pathophysiological conditions [13]. The secretion and composition of saliva might be affected by various diseases, including gastrointestinal, thyroid, oncological, autoimmune, cardiovascular, neurological and other disorders [14][15][16][17][18][19][20][21].…”

Section: Introductionmentioning

confidence: 99%

Salivary Biomarkers for Alzheimer’s Disease: A Systematic Review with Meta-Analysis

Nijakowski,

Owecki,

Jankowski

et al. 2024

IJMS

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Alzheimer’s Disease (AD) is the most common neurodegenerative disease which manifests with progressive cognitive impairment, leading to dementia. Considering the noninvasive collection of saliva, we designed the systematic review to answer the question “Are salivary biomarkers reliable for the diagnosis of Alzheimer’s Disease?” Following the inclusion and exclusion criteria, 30 studies were included in this systematic review (according to the PRISMA statement guidelines). Potential biomarkers include mainly proteins, metabolites and even miRNAs. Based on meta-analysis, in AD patients, salivary levels of beta-amyloid42 and p-tau levels were significantly increased, and t-tau and lactoferrin were decreased at borderline statistical significance. However, according to pooled AUC, lactoferrin and beta-amyloid42 showed a significant predictive value for salivary-based AD diagnosis. In conclusion, potential markers such as beta-amyloid42, tau and lactoferrin can be detected in the saliva of AD patients, which could reliably support the early diagnosis of this neurodegenerative disease.

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Saliva diagnostics: emerging techniques and biomarkers for salivaomics in cancer detection

Cited by 9 publications

References 161 publications

Plasmon resonance biosensor for interleukin-1β point-of-care determination: A tool for early periodontitis diagnosis

Plasmon resonance biosensor for interleukin-1β point-of-care determination: A tool for early periodontitis diagnosis

Microbes for lung cancer detection: feasibility and limitations

Salivary Biomarkers for Alzheimer’s Disease: A Systematic Review with Meta-Analysis

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