Saliva: plasma concentration relationships for sulphapyridine following sulphasalazine administration to normal volunteers and patients with inflammatory bowel disease.

Day, J; Houston, J. Brian

doi:10.1111/j.1365-2125.1980.tb04802.x

Cited by 12 publications

(3 citation statements)

References 7 publications

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“…This behaviour indicates that the disposition of the acetyl conjugate is formation rate limited. The ratio of conjugate AUC to sulphapyridine AUC is a measure of acetylator status (Day & Houston, 1980). In four subjects this ratio is less than 0.6 which is consistent with slow acetylator status.…”

Section: Resultsmentioning

confidence: 83%

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Azo reduction of sulphasalazine in healthy volunteers.

Houston¹,

Day²,

Walker³

1982

Brit J Clinical Pharma

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1 A comparison of total sulphapyridine saliva concentrations resulting from administration of sulphapyridine and sulphasalazine at equimolar doses has been carried out. It is concluded that the extent of azo reduction of sulphasalazine to release sulphapyridine is complete in healthy volunteers. 2 An ampicillin course of treatment alters the azo reduction of sulphasalazine. The extent of cleavage is reduced by one third on average. There is no change in the rate of absorption of the release sulphapyridine. 3 An ampicillin course of treatment does not alter the disposition of sulphapyridine. The changes noted in acetyl conjugate plasma concentrations are entirely consistent with reduced availability of sulphapyridine.

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Section: Resultsmentioning

confidence: 83%

“…The saliva:plasma concentration ratio for sulphapyridine and its acetyl conjugate has been shown to be constant (Bates et al, 1978;Day & Houston, 1980). Therefore the saliva data presented may be regarded as representative of plasma concentrationtime relationships.…”

Section: Discussionmentioning

confidence: 99%

Azo reduction of sulphasalazine in healthy volunteers.

Houston¹,

Day²,

Walker³

1982

Brit J Clinical Pharma

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“…The regional kinetics in colon and rectum of 5-ASA have earlier been investigated only indirectly in studies on peroral SASP (27,29,82,102,124,111) in as much as the regional kinetics depend on the azo-drug itself (see Fig. 1).…”

Section: Vi3 I Backgroundmentioning

confidence: 99%