Salivary and serum cortisol in patients with periodontal disease and oral lichen planus.

Miricescu, Daniela; Totan, Alexandra; Calenic, Bogdan; Mocanu, Brânduşa; Greabu, Maria

doi:10.25241/stomaeduj.2015.2(1).art.5

Cited by 4 publications

(16 citation statements)

References 24 publications

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“…In this regard, lack of significance with the other used methods may be due to the low number of reported studies. Out of 10 studies reported [1,8,18,19,20,21,22,23,24,25] in the present meta-analysis, six studies [1,18,19,21,23,24] showed a higher significant level of salivary cortisol in the OLP patients compared with the controls.…”

Section: Discussionmentioning

confidence: 62%

“…The studies were published from 2003 to 2017 and included 269 OLP patients and 268 controls. Four studies were reported from India [1,18,19,20], three from the Middle East [21,22,23], two from Europe [24,25], and one from Brazil [8]. In six studies [1,18,21,22,23,24], the detection method of salivary cortisol level was enzyme-linked immunosorbent assay (ELISA), whereas the remaining methods were radioimmunoassay in one study [8] and the chemiluminescence immunoassay in three studies [19,20,25].…”

Section: Resultsmentioning

confidence: 99%

“…Four studies were reported from India [1,18,19,20], three from the Middle East [21,22,23], two from Europe [24,25], and one from Brazil [8]. In six studies [1,18,21,22,23,24], the detection method of salivary cortisol level was enzyme-linked immunosorbent assay (ELISA), whereas the remaining methods were radioimmunoassay in one study [8] and the chemiluminescence immunoassay in three studies [19,20,25]. Eight studies [1,8,18,19,21,22,23,24] had case-control design and two studies [20,25] had comparative cross-sectional design.…”

Section: Resultsmentioning

confidence: 99%

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Evaluation of the Salivary Level of Cortisol in Patients with Oral Lichen Planus: A Meta-Analysis

et al. 2019

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Background and objective: Cortisol, as the main human glucocorticoid, is considered to be a biological marker of stress and anxiety. Since it is known that oral lichen planus (OLP) can appear and worsen during stressful events, cortisol levels have been previously studied in OLP patients. The present meta-analysis aims to assess the salivary concentration of cortisol in OLP patients compared to healthy controls. Materials and methods: Web of Science, PubMed, Cochrane Library, and Scopus databases were searched up to October 2018. The RevMan 5.3 software was used with the mean difference (MD) and 95% confidence intervals (CIs). The CMA 2.0 Software was used to evaluate the publication bias, sensitivity analysis, and meta-regression as possible sources of heterogeneity. Results: 10 studies were analyzed and a total of 269 OLP patients and 268 controls were included. The pooled MD of the salivary levels of cortisol in OLP patients compared with controls was 4.27 ng/mL (95% CI: 2.33, 6.21; P < 0.0001), thus, the salivary level of cortisol in OLP patients was significantly higher than in controls. In Indian-based population studies, a significant difference in the salivary cortisol levels in OLP patients compared with controls was detected (MD = 5.62 ng/mL; 95% CI: 2.67, 8.56; P = 0.0002). In addition, a significant difference in the salivary cortisol levels in the OLP patients compared with the controls was obtained in studies performed with enzyme-linked immunosorbent assay (ELISA) method (MD = 5.33 ng/mL; 95% CI: 2.72, 7.93; P < 0.0001). Conclusion: We suggest that supportive psychological treatment together with the conventional therapy could increase patients’ capability to prevent stress, anxiety, and depression.

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Section: Discussionmentioning

confidence: 62%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Evaluation of the Salivary Level of Cortisol in Patients with Oral Lichen Planus: A Meta-Analysis

et al. 2019

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“…About 57.14% estimated the serum cortisol levels by using Electrochemiluminescence method,[ 1 3 5 10 ] whereas the remaining methods were ELISA in one study (14.28%),[ 11 ] Chemiluminescence in another study (14.28%),[ 12 ] and Enhanced Lanthanide Fluoroimmunoassay in yet another study (14.28%). [ 13 ] All the seven studies (100%) analyzed serum cortisol levels in both LP and control group, which resulted in statistically higher serum cortisol levels than the control group.…”

Section: Discussionmentioning

confidence: 99%

Serum Cortisol Levels in Lichen Planus

Sushanthi

Ramani

Ramasubramanian

et al. 2021

Indian Journal of Dermatology

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Lichen planus (LP) is an autoimmune, mucocutaneous, T-cell mediated chronic inflammatory disease that involves the oral mucosa. The prevalence of LP is 0.04–2% in general population with a female predilection. Patients with skin lesions also manifest oral lesions predominantly and about 25% present with only oral lesions. The aim of the systematic review is to analyze the serum cortisol levels in LP patients to elucidate the role of cortisol in pathogenesis of the lesion. A comprehensive search was done using electronic data bases such as PUBMED, EMBASE, SCIENCE DIRECT, COCHRANE, GOOGLE, manual search, and back references of the articles were extracted. A total of seven relevant articles were reviewed and analyzed. Electronic database and manual search identified 55 articles. Out of which, 33 were excluded after reading titles and removing duplication and 23 studies were evaluated in detail after reading the abstract and full text. A final of seven studies were included based on the inclusion criteria to meet the research question. All the studies analyzed the serum cortisol levels in LP patients and also in healthy subjects. Within the limitations of this review, it can be inferred that Cortisol is an established stress hormone and Serum cortisol estimation could be an important indicator in identifying susceptible oral lichen planus patients.

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“…Furthermore, some studies showed a positive correlation between the level of oxidative stress and the concentration of free salivary cortisol. Increased levels of cortisol have been found in patients with various forms of periodontitis and anxiety [ 16 , 17 ].…”

Section: Introductionmentioning

confidence: 99%

The Effects of Prednisone/Ketoprofen Administration in Association with Amoxicillin Clavulanate Following Periodontal Surgical Therapy in Patients with Severe Chronic Periodontitis

et al. 2021

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Background and Objectives: The aim of this study was to evaluate and compare the effects of two different anti-inflammatory drugs (ketoprofen and prednisone) combined with an antibiotic (amoxicillin + clavulanic acid) and periodontal surgery on dental and periodontal parameters in patients with severe chronic periodontitis. In addition, salivary stress expressed by cortisol levels was assessed. Materials and Methods: An interventional study was performed on 22 periodontal subjects and 19 clinical healthy controls. The patients were divided in four groups, depending on treatment planning, as follows: eight patients received prednisone and antibiotherapy, associated with surgical periodontal therapy; seven patients received ketoprofen and antibiotherapy, associated with surgical periodontal therapy (group II); seven patients received only prednisone. Periodontal healthy patients underwent routine scaling and polishing. Bleeding on probing (BOP), dental mobility and salivary cortisol (ng/mL) were assessed before and after treatment. The means and standard deviations for the salivary cortisol levels (SCLs), dental and periodontal parameters were calculated for all groups using each patient as a unit of analysis. Results: Data analyses showed that the two different anti-inflammatory drugs associated with or without surgical therapy were efficient on inflammation periodontal parameters (BOP, dental mobility). Prednisone treatment alone was associated with a significant decrease of SCLs between pretreatment and post-treatment. Conclusions: In the present study, the effects of either of the anti-inflammatory drugs on inflammation evolution and salivary stress were comparable in patients undergoing antibiotherapy and surgical periodontal therapy.

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Salivary and serum cortisol in patients with periodontal disease and oral lichen planus.

Cited by 4 publications

References 24 publications

Evaluation of the Salivary Level of Cortisol in Patients with Oral Lichen Planus: A Meta-Analysis

Evaluation of the Salivary Level of Cortisol in Patients with Oral Lichen Planus: A Meta-Analysis

Serum Cortisol Levels in Lichen Planus

The Effects of Prednisone/Ketoprofen Administration in Association with Amoxicillin Clavulanate Following Periodontal Surgical Therapy in Patients with Severe Chronic Periodontitis

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