Salivary biomarkers for predicting the progression of chronic periodontitis

Nomura, Yasuo; Shimada, Yukiyasu; Hanada, Nobuhiro; Numabe, Yukihiro; Kamoi, Kazumi; Sato, Tsutomu; Gomi, Kazuhiro; Arai, Takashi; Inagaki, Koji; Fukuda, Mitsuo; Noguchi, Toshihide; Yoshie, Hiromasa

doi:10.1016/j.archoralbio.2011.09.011

Cited by 86 publications

(101 citation statements)

References 33 publications

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“…In CPI method, periodontal pocket probing depth is examined and the degree of periodontitis is determined by gingival bleeding, presence of tartar and depth of periodontal pocket. However, this method requires time, can be troublesome, and it is also occasionally not reliable, thus making it unsuitable for a large number of subjects (30)(31)(32)(33). Recently, several biomarkers in saliva, such as aspartate aminotransferase (AST), alanine aminotransferase (ALT), lactate dehydrogenase (LDH), creatinine, blood urea nitrogen (BUN), urea and hemoglobin (Hb), have been demonstrated to be useful to evaluate the periodontal status (30)(31)(32)(33).…”

Section: Methodsmentioning

confidence: 99%

“…However, this method requires time, can be troublesome, and it is also occasionally not reliable, thus making it unsuitable for a large number of subjects (30)(31)(32)(33). Recently, several biomarkers in saliva, such as aspartate aminotransferase (AST), alanine aminotransferase (ALT), lactate dehydrogenase (LDH), creatinine, blood urea nitrogen (BUN), urea and hemoglobin (Hb), have been demonstrated to be useful to evaluate the periodontal status (30)(31)(32)(33). In this study, the concentrations of LDH and Hb in saliva were used to examine the periodontal status, since saliva concentrations of LDH and Hb have been demonstrated to correlate with the degree of periodontitis measured by the CPI method (32,33).…”

Section: Methodsmentioning

confidence: 99%

“…Recently, several biomarkers in saliva, such as aspartate aminotransferase (AST), alanine aminotransferase (ALT), lactate dehydrogenase (LDH), creatinine, blood urea nitrogen (BUN), urea and hemoglobin (Hb), have been demonstrated to be useful to evaluate the periodontal status (30)(31)(32)(33). In this study, the concentrations of LDH and Hb in saliva were used to examine the periodontal status, since saliva concentrations of LDH and Hb have been demonstrated to correlate with the degree of periodontitis measured by the CPI method (32,33). LDH and Hb concentrations in saliva are considered to reflect the degree of destruction of periodontal tissue and the grade of gingival bleeding due to periodontitis, respectively (32).…”

Section: Methodsmentioning

confidence: 99%

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A Study on the Relationship between Reflux Esophagitis and Periodontitis

et al. 2016

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Objective Metabolic syndrome and dental erosion have been demonstrated to correlate with gastroesophageal acid reflux disease (GERD), while periodontitis has been reported to have a positive relationship with metabolic syndrome. However, no correlation between periodontitis and GERD has yet been reported. We therefore investigated the relationship between periodontitis and GERD. Methods The subjects consisted of 280 individuals who visited the Health Center for a detailed medical checkup examination. Each underwent upper endoscopy and periodontitis examinations, with the latter performed by measuring the concentrations of lactate dehydrogenase and hemoglobin in saliva. The subjects were divided into those with positive and negative periodontitis findings, and the prevalence rates of endoscopically proven reflux esophagitis, dyslipidemia, hypertension, and hyperglycemia were compared. Results The number of subjects positive for periodontitis was 93, while 187 had negative findings. The prevalence of reflux esophagitis was not different between the positive and negative groups (8.6% vs. 8.0%). In addition, a multiple logistic regression analysis did not identify a positive relationship between the presence of periodontitis and reflux esophagitis. On the other hand, dyslipidemia and hypertension were more frequently observed in the subjects that were positive for periodontitis. Conclusion We did not find an association between periodontitis and reflux esophagitis in the present study. On the other hand, the presence of periodontitis was found to correlate with hypertension and dyslipidemia.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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A Study on the Relationship between Reflux Esophagitis and Periodontitis

et al. 2016

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“…Therefore, during recent decades detecting biomarkers for diagnosis of periodontal disease has attracted attention (4,5,10). Periodontal disease biomarkers are substances that could be produced during the host's defensive responses against bacterial invasion, reflect inflammation, or be released from cell death as a result of tissue destruction due to periodontal disease (4,14). The diagnostic efficacy of various biomarkers of periodontal disease has been demonstrated in previous studies (20)(21)(22).…”

Section: Discussionmentioning

confidence: 99%

“…Among the resources available for obtaining biomarkers, saliva is an important biological substance. It contains biomarkers excreted from serum, gingival crevicular fluid, and mucosal transudate that could be helpful in detecting and explaining the pathogenesis of several systemic diseases, including periodontal disease (4,(13)(14)(15). The advantages of using this source of biomarkers include its ease of collection, the low cost of the test, and the fact that the test is not technique sensitive or invasive (4,5,13,16).…”

Section: Introductionmentioning

confidence: 99%

Comparison of Whole Salivary Lactate Dehydrogenase Level in Patients With and Without Periodontal Disease

Haghgoo¹,

Soheilifar²,

Bidgoli³

et al. 2016

Avicenna J Dent Res

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Background: Tracking various biomarkers in serum, gingival crevicular fluid (GCF), and saliva has been introduced as a diagnostic tool for periodontal disease detection. Objectives: The aim of this study was to compare salivary lactate dehydrogenase (LDH) levels in subjects with periodontal disease and levels in subjects without periodontal disease. Materials and Methods:In this case-control study, 170 patients at Hamadan faculty of Dentistry, including patients with periodontal disease and patients with normal periodontium, were selected and divided into test and control groups. Unstimulated saliva was collected in the same situation from the test and control groups. Each saliva sample was analyzed to measure salivary LDH level on the day of collection, by using commercially available kits according to the manufacturers' instructions. A statistical T-test was employed to evaluate significant differences among groups.

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Mass spectrometry‐based proteomic approaches for salivary protein biomarkers discovery and dental caries diagnosis: A critical review

Ahmad

Hussain

Siqueira

2022

Mass Spectrometry Reviews

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Dental caries is a multifactorial chronic disease resulting from the intricate interplay among acid‐generating bacteria, fermentable carbohydrates, and several host factors such as saliva. Saliva comprises several proteins which could be utilized as biomarkers for caries prevention, diagnosis, and prognosis. Mass spectrometry‐based salivary proteomics approaches, owing to their sensitivity, provide the opportunity to investigate and unveil crucial cariogenic pathogen activity and host indicators and may demonstrate clinically relevant biomarkers to improve caries diagnosis and management. The present review outlines the published literature of human clinical proteomics investigations on caries and extensively elucidates frequently reported salivary proteins as biomarkers. This review also discusses important aspects while designing an experimental proteomics workflow. The protein–protein interactions and the clinical relevance of salivary proteins as biomarkers for caries, together with uninvestigated domains of the discipline are also discussed critically.

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Salivary biomarkers for predicting the progression of chronic periodontitis

Cited by 86 publications

References 33 publications

A Study on the Relationship between Reflux Esophagitis and Periodontitis

A Study on the Relationship between Reflux Esophagitis and Periodontitis

Comparison of Whole Salivary Lactate Dehydrogenase Level in Patients With and Without Periodontal Disease

Mass spectrometry‐based proteomic approaches for salivary protein biomarkers discovery and dental caries diagnosis: A critical review

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