Salivary Biomarkers in Systemic Sclerosis Disease

Zian, Zeineb; Bakkach, Joaira; Barakat, Amina; Nourouti, Naima Ghailani; Mechita, Mohcine Bennani

doi:10.1155/2018/3921247

Cited by 8 publications

(7 citation statements)

References 60 publications

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“…In recent years, the changes in expression levels and expression patterns of salivary proteins under different disease states and physiological conditions have made them an essential breakthrough in studying the etiology, diagnosis and prognosis of these diseases (Zian et al, 2018;Finamore et al, 2020;Tvarijonaviciute et al, 2020). Changes in salivary protein in states of different blood glucose levels have become a hot spot in the study of the relationship between the oral cavity and diabetes (Bencharit et al, 2013;Lima-Aragão et al, 2016).…”

Section: Analysis Of the Discriminating Ability Of Candidate Proteinsmentioning

confidence: 99%

Impact of the Glycemic Level on the Salivary Proteome of Middle-Aged and Elderly People With Type 2 Diabetes Mellitus: An Observational Study

Jia

Zhang

Sun

et al. 2021

Front. Mol. Biosci.

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Type 2 diabetes mellitus (T2DM) is an increasing global public health concern, but its impact on the salivary proteome is still unclear. To evaluate the effect of glycemic levels in middle-aged and elderly individuals with T2DM on salivary proteomics, we compared the differences by liquid chromatography tandem mass spectrometry (LC–MS/MS). Unstimulated whole saliva samples from 8 T2DM patients with good glycemic control (G group, HbA1c <6.5%) and 16 patients with poor control (P group, HbA1c ≥6.5%) were analyzed by LC–MS/MS in the data-independent acquisition mode (Clinical register number: ChiCTR1900023582.). After functional annotation, cluster analysis and receiver operating characteristic (ROC) curve analysis were carried out to screen and evaluate candidate proteins. A total of 5,721 proteins were quantified, while 40 proteins differed significantly. In the P group, proteins involved in oxidative stress-related processes were upregulated, whereas proteins related to salivary secretion were downregulated. The combination of thioredoxin domain-containing protein 17, zymogen granule protein 16B, and FAM3 metabolism regulating signaling molecule D yielded an area under the curve of 0.917 which showed a robust ability to distinguish the P and G groups. In conclusion, poorly controlled hyperglycemia may affect salivary proteins through various pathways, including oxidative stress and glandular secretion. Furthermore, the differentially expressed proteins, especially the three proteins with the best differentiation, might serve as an anchor point for the further study of hyperglycemia and oral diseases.

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Section: Analysis Of the Discriminating Ability Of Candidate Proteinsmentioning

confidence: 99%

Impact of the Glycemic Level on the Salivary Proteome of Middle-Aged and Elderly People With Type 2 Diabetes Mellitus: An Observational Study

Jia

Zhang

Sun

et al. 2021

Front. Mol. Biosci.

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“…However, the use of saliva in the diagnosis is combined in two directions: the detection of diseases of the oral cavity [26][27][28][29][30][31] and the identification of pathologies of the organism as a whole. [32][33][34][35][36] In the first case, it is sufficient to determine the corresponding biochemical indicator for the control group and in the presence of oral diseases. In the second case, there is a need to compare the result with the reference value (serum or plasma).…”

Section: Introductionmentioning

confidence: 99%

Age and gender characteristics of the biochemical composition of saliva: Correlations with the composition of blood plasma

Bel’skaya

Sarf

Kosenok

2020

Journal of Oral Biology and Craniofacial Research

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Background: Recently, the attention of researchers to the study of the properties of human saliva, as a material with unique properties and diagnostic capabilities, has increased. Research objective: to study the connection of the biochemical composition of saliva and blood plasma in the norm, depending on gender and age. Methods: 107 volunteers took part in the study, including 46 female (37.2 ± 3.9 years old) and 61 male (36.1 ± 2.8 years old). In all samples of saliva and blood plasma, 16 biochemical parameters were determined, including mineral and protein composition, enzyme activity. Non-parametric statistical methods were used to process the data. Results: It has been shown that it is difficult to establish an unambiguous relation between biochemical parameters of saliva and blood plasma. The calculation of the Spearman correlation coefficients showed that only 7 of the 16 parameters demonstrate the presence of a weak correlation between the content in saliva and plasma. Conclusion: In general, the determination of the composition of saliva may have an independent diagnostic value; in this case, drawing a parallel with the composition of serum and blood plasma is not advisable. Nevertheless, the use of saliva in clinical laboratory diagnostics is associated with the need to establish criteria for the norm and pathology for each biochemical parameter.

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“…In the last decades, saliva has been proved to be a reliable source for the detection of biomarkers in different local and systemic diseases [19][20][21][22] since it reflects both local and general health of the human body.…”

Section: Characteristics Of Saliva As a Diagnostic Fluidmentioning

confidence: 99%

Salivary Cytokines as Potential Diagnostic Biomarkers for Systemic Lupus Erythematosus Disease

Zian

Bouhoudan

Mourabit

et al. 2021

Mediators of Inflammation

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Systemic lupus erythematosus (SLE) is a complex autoimmune inflammatory disease characterized by an unknown etiology and a highly variable clinical presentation. This clinical heterogeneity might be explained by dysregulation of tolerance to self and apoptotic mechanisms, overproduction of autoantibodies, and abnormal cytokine levels. Cytokine imbalance levels have been associated with disease activity and severity in SLE patients. In the last years, salivary cytokines related to SLE have gained significant attention and researchers have begun to focus on the identification of cytokines in the saliva of SLE patients using it as a diagnostic fluid for the inflammatory process underlying SLE. This review highlights and summarizes recent studies revealing the cytokines that have been identified in the saliva of individuals with SLE. Data reported and discussed in this report may provide useful additional information to better understand the mechanisms associated with the disease.

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Salivary Biomarkers in Systemic Sclerosis Disease

Cited by 8 publications

References 60 publications

Impact of the Glycemic Level on the Salivary Proteome of Middle-Aged and Elderly People With Type 2 Diabetes Mellitus: An Observational Study

Impact of the Glycemic Level on the Salivary Proteome of Middle-Aged and Elderly People With Type 2 Diabetes Mellitus: An Observational Study

Age and gender characteristics of the biochemical composition of saliva: Correlations with the composition of blood plasma

Salivary Cytokines as Potential Diagnostic Biomarkers for Systemic Lupus Erythematosus Disease

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