Salivary duct carcinoma—A clinicopathologic study of 12 cases

Abstract

Salivary duct carcinoma (SDC), a recently defined malignant tumor usually of major salivary glands, has probably been included in the group of adenocarcinomas, NOS. As yet, only a few descriptions of its clinical behavior have appeared. We have found 12 cases of SDC treated at our institution since 1970 and have reviewed their presentation and course. Despite total parotidectomy in most cases and radiotherapy in all, most patients have succumbed to their tumors, six with distant metastases. SDC appears to be a highly malignant tumor requiring aggressive combined therapy for locoregional control. The high incidence of systemic spread indicates a need for effective chemotherapy on an adjuvant basis.

Homologous Carcinomas of the Breasts, Skin, and Salivary Glands:A Histologic and Immunohistochemical Comparison of Ductal Mammary Carcinoma, Ductal Sweat Gland Carcinoma, and Salivary Duct Carcinoma

“…Other markers included in our assessment, including ERP and PRP, had no discriminant value. In that regard, the data described herein reaffirm our earlier findings 49 and differ from those reported by Lloveras et al 5 0 It should be remembered, however, that most cases of IDCB in the current series were in men; therefore, these cases may have skewed the study population of such tumors toward ERP positivity. 6 A parenthetical comment must be made on the possible differential diagnosis of IDCB and DSGC in the skin of the breast itself.…”

“…5 ' 12 " 25 They showed an intraductal and invasive proliferation of large p o l y g o n a l cells with overtly malignant cytologic features. These included high nucleocytoplasmic ratios, vesicular or coarsely c l u m p e d c h r o m a t i n , p r o m i n e n t nucleoli, brisk mitotic activity (> 2 mitoses per 10 high-power fields), and granular or "glassy" eosinophilic cytoplasm (Fig 4).…”

“…Since then, many other reports on SDC, which have served to establish the characteristic clinicopathologic attributes of the tumor, have been published. 5 ' 12-25 ' [53][54][55] It most often is seen in middle-aged or elderly men (average age, 64 years), although cases have been reported in young adults as well. 54 The parotid glands most often give rise to SDC, followed in order by the submandibular glands and minor salivary gland sites.…”

Salivary Duct Carcinoma

“…[1][2][3][4][5]10,13,[16][17][18]21,23,27 Early diagnosis and treatment appear to be important as this tumor is known to metastasize early. 2,4,7,10,27 Although …”

Primary Epithelial Tumors of Salivary Glands.Histomorphological and Immunohistochemical Implications.

“…These carcinomas also show ductal and papillary configurations and should be differentiated from acinic cell carcinoma, mucoepidermoid carcinoma, papillary cystadenocarcinoma, polymorphous low-grade adenocarcinoma, epithelial-myoepithelial carcinoma and oncocytic carcinoma [1,4,55,70,71,73]. The tumor has been found to be immunoreactive for cytokeratins, variably reactive EMA and unreactive for S-100 protein and myosin [107].…”