Salivary Fluoride Bioavailability after Brushing with Brazilian Red Propolis Dentifrice: A Clinical Study

Abstract

Introduction. Fluoride plays an important role in the control of dental caries, and currently new dentifrices are being associated with natural products. Objective. This study aimed to evaluate the availability of fluoride in saliva samples after using a dentifrice incorporated with Brazilian red propolis (BRP, INPI Patent no. BR1020170110974) and to compare it to a conventional fluoridated dentifrice in healthy participants. Methods. This study was conducted implementing a double-blind, randomized, controlled, and crossover design. Saliva samples of participants were collected at the following time points: 0 at baseline and 5, 15, 30, 45, and 60 minutes after brushing with each dentifrice. Salivary fluoride concentrations showed no statistically significant difference when comparing the two treatments ( p > 0.05 ). All available fluoride concentrations in saliva decreased after one hour, with no significant difference between BRP and conventional fluoridated dentifrice treatment samples ( p > 0.05 ). Results. The results showed that there was no difference between the analyzed fluoride concentrations 1 hour after brushing with the different dentifrices. Conclusions. The results of this study suggest that the propolis incorporated in the dentifrice did not interfere with the kinetics and bioavailability of the fluoride ion in saliva samples, enabling its integration with the pharmaceutical formula and thereby promoting its anti-inflammatory and antimicrobial benefits without compromising the anticaries activity of the formulation.

Remineralization, color stability and surface roughness of tooth enamel brushed with activated charcoal‐based products

“…33 Conversely, NaF do not requires this step to start its action. 33 Saliva has a significant role in dental remineralization, and the immersion in saliva could have produced different results. 5,33 Therefore, it would be necessary to conduct further studies evaluating its synergistic effect with ACPs.…”

“…MFP undergoes hydrolysis to release fluoride ions in the oral cavity. Salivary enzymes have hydrolytic action on MFP and the storage in saliva could have enhanced its effectiveness 33 . Conversely, NaF do not requires this step to start its action 33 .…”

“…Salivary enzymes have hydrolytic action on MFP and the storage in saliva could have enhanced its effectiveness 33 . Conversely, NaF do not requires this step to start its action 33 . Saliva has a significant role in dental remineralization, and the immersion in saliva could have produced different results 5,33 .…”

“…33 Saliva has a significant role in dental remineralization, and the immersion in saliva could have produced different results. 5,33 Therefore, it would be necessary to conduct further studies evaluating its synergistic effect with ACPs. 5 ACPs can promote tooth color change by removing extrinsic stains but also, by adsorbing extrinsic stains 7 and chromophores from the enamel surface.…”

Physicochemical Evaluation of a Toothpaste Incorporated with Brazilian Red Propolis

“…In addition, it has been found to reduce inflammatory cytokines from gingivitis [16,17] and has a good acceptance in orthodontic patients [18]. As for the availability of fluoride in saliva, it showed kinetics similar to a commercial toothpaste [19]. However, given the possibility of one day becoming commercial, studies -related to stability -are essential.…”