Salivary gland function after sialendoscopy for treatment of chronic radioiodine‐induced sialadenitis

Abstract

These results show that sialendoscopy can improve obstructive symptoms; however, it seems to have some limitations for relief of xerostomia and improvement of salivary gland dysfunctions in recalcitrant chronic radioactive iodine sialadenitis.

Usefulness of Magnetic Resonance Sialography for the Evaluation of Radioactive Iodine-Induced Sialadenitis

“…More specifically, we directly visualized parotid ducts in RAI sialadenitis by sialendoscopy and found that RAI-damaged ducts showed findings such as bleached ductal walls, lumen stricture, and the impaction of mucous plugs and debris. 6 Degrees of ductal stricture also varied from edema with sialodochitis to severe stenosis. 6 Parotid gland impairment is usually more common than submandibular gland impairment after RAI therapy.…”

“…6 Degrees of ductal stricture also varied from edema with sialodochitis to severe stenosis. 6 Parotid gland impairment is usually more common than submandibular gland impairment after RAI therapy. 17 In our study, grades of abnormal ductal and parenchymal findings were significantly higher for parotid glands than submandibular glands.…”

“…For functional evaluations, parameters such as uptake ratio (UR), time from stimulation to minimum count (t min ), maximum accumulation (MA), and maximum secretion (MS) were calculated. 6 Magnetic Resonance (MR) Sialography MR sialography was performed on all patients with clinically suspected RAI-induced sialadenitis. Patients with a history of radiotherapy, SG disease, or autoimmune disease were excluded, as were patients with severe motion artifacts on MR images that affected image interpretation.…”

A Randomized Controlled Trial for the Effectiveness of Aromatherapy in Decreasing Salivary Gland Damage following Radioactive Iodine Therapy for Differentiated Thyroid Cancer

“…The parotid gland has a tendency to develop RAI sialadenitis earlier than the submandibular gland, even though NIS expression in the parotid glands does not exceed that in the submandibular gland [30]. This propensity is attributed to the higher clearance rate of salivary secretion in the submandibular glands [6, 10, 30]. We postulate that the effects of aromatherapy on submandibular gland damage are similar to those in the parotid glands; however, future studies are needed to confirm this hypothesis.…”

“…Saliva lubricates the oral mucosa, which allows proper speaking, swallowing, and tasting [5]. The prevalence of chronic RAI sialadenitis, an inflammation of the salivary glands, ranges from 11% to 67% after RAI therapy [6–11]. This condition causes pain and swelling which lead to oral discomfort [5, 7].…”