Salivary gland structure and function in experimental diabetes mellitus

Anderson, Leigh C.

doi:10.14748/bmr.v9.141

Cited by 7 publications

(6 citation statements)

References 82 publications

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“…Some metabolic insults cause disruption of normal lipid transport and metabolism and subsequently cause accumulation of lipid within the cytoplasm. In the streptozotocin-diabetes rat model, the parotid is the major salivary gland most susceptible to cytoplasmic vacuolation ( Anderson 1998 ). Cytoplasmic vacuolation within the parotid was observed in doxylamine treated F344 rats ( Jackson and Blackwell 1988 ).…”

Section: Salivary Glandsmentioning

confidence: 99%

Nonproliferative and Proliferative Lesions ofthe Gastrointestinal Tract, Pancreas andSalivary Glands of the Rat and Mouse

et al. 2016

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The INHAND (International Harmonization of Nomenclature and Diagnostic Criteria for Lesions in Rats and Mice) project is a joint initiative of the Societies of Toxicologic Pathology from Europe (ESTP), Great Britain (BSTP), Japan (JSTP), and North America (STP) to develop an internationally accepted nomenclature and diagnostic criteria for nonproliferative and proliferative lesions in laboratory animals. The purpose of this publication is to provide a standardized nomenclature and diagnostic criteria for classifying lesions in the digestive system including the salivary glands and the exocrine pancreas of laboratory rats and mice. Most lesions are illustrated by color photomicrographs. The standardized nomenclature, the diagnostic criteria, and the photomicrographs are also available electronically on the Internet (http://www.goreni.org/). Sources of material included histopathology databases from government, academia, and industrial laboratories throughout the world. Content includes spontaneous and age related lesions as well as lesions induced by exposure to test items. Relevant infectious and parasitic lesions are included as well. A widely accepted and utilized international harmonization of nomenclature and diagnostic criteria for the digestive system will decrease misunderstandings among regulatory and scientific research organizations in different countries and provide a common language to increase and enrich international exchanges of information among toxicologists and pathologists.

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Section: Salivary Glandsmentioning

confidence: 99%

Nonproliferative and Proliferative Lesions ofthe Gastrointestinal Tract, Pancreas andSalivary Glands of the Rat and Mouse

et al. 2016

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“…Streptozotocin (STZ) was the drug of choice in this study to induce diabetes as it had low mortality rate and high tolerance by the experimental animals than alloxan. Also, it can be given easily by different routes and its diabetogenic action was rapid and permanent as it is known to destroy the beta cells of islets of Langerhans (18) .…”

Section: Discussionmentioning

confidence: 99%

Effect of mesenchymal bone marrow stem cells on the periodontal ligament of induced Diabetic Rats.

Mohammed

Taha

Ghali

2021

Dental Science Updates

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Introduction: Considering the Diabetes mellitus (DM) as one of the oldest conditions characterized in humans, it has been recognized since antiquity and considered as a major health problem at present. There is a need for efficient treatment. Aim: The aim of the present investigation was to find out whether stem cells can alleviate the well documented side effects of streptozotocin induced diabetes mellitus on the periodontal ligament of adult male albino rats. Material and Methods: Sixty adult male albino rats with body were used in this investigation. They were divided into the following three groups; Group 1: consisted of 20 animals and served as controls; Group 2: consisted of 20 animals, they were subjected to a single intraperitoneal injection of streptozotocin in a dose of 60mg. /kg body weight for induction of diabetes mellitus; Group 3: consisted of 20 animals. They were subjected to induction of diabetes mellitus in the same way as group 2 animals. One week later, the animals were subjected to a single intravenous infusion of mesenchymal bone marrow stem cells. At the end of the experiment one week later the animals were euthanized by cervical dislocation, their jaws dissected out, decalcified then processed for A. histological examination (Hematoxylin and Eosin stain) B. transmission electron microscope. Results: Histological examination in the present work showed that the treatment of diabetic rats with stem cells resulted in amelioration of the degenerative effects of diabetes on the periodontal ligament in group 2 and regenerative changes of stem cells in group 3 compared to the control group 1. Electron microscopic examination of the PDL showed marked regenerative changes in the density of collagen. Conclusion: Diabetic albino rats treated with stem cells revealed partial improvements, mostly in the arrangement of the fibers of periodontal ligament. The ultrastructural features showed normal fibroblasts.

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Section: Discussionmentioning

confidence: 99%

Effect of statins on the periodontal ligament and Alveolar process of induced Diabetic Rats

Mohammed

Taha

Ghali

2021

Dental Science Updates

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Introduction: Considering the Diabetes mellitus (DM) as one of the oldest conditions characterized in humans, it has been recognized since antiquity and considered as a major health problem at present. There is a need for efficient treatment. Aim: The aim of the present investigation was to find out whether statins can alleviate the well documented side effects of Streptozotocin induced diabetes mellitus on the periodontal ligament of adult male Albino rats. Material and Methods: Sixty adult male albino rats with body weight ranging from180-200gr were used in this investigation. They were divided into the following groups. Group 1: consisted of 20 animals and served as controls. Group 2: consisted of 20 animals, they were subjected to a single intraperitoneal injection of streptozotocin in a dose 60 mg/kg body weight of for induction of diabetes mellitus. Group 3: consisted of 20 animals. They were subjected to induction of diabetes mellitus in the same way as group 2 animals. One week later, the animals were treated with simvastatin in a daily intraperitoneal dose of 5mg/kg body weight. At the end of the experiment the animals were sacrificed by cervical dislocation, their Jaws were dissected out then processed for the histological and transmission electron microscopic examinations. Results: The present work showed that the treatment of diabetic rats with statins resulted in amelioration of the degenerative effect of diabetes on the periodontal ligament when compared with. Changes of diabetes in group 2 and regenerative changes of statins in group 3 compared to the control group 1. Conclusion: Diabetic albino rats treated with statins revealed partial improvements, mostly in the arrangement of the fibers of periodontal ligament.

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Salivary gland structure and function in experimental diabetes mellitus

Cited by 7 publications

References 82 publications

Nonproliferative and Proliferative Lesions ofthe Gastrointestinal Tract, Pancreas andSalivary Glands of the Rat and Mouse

Nonproliferative and Proliferative Lesions ofthe Gastrointestinal Tract, Pancreas andSalivary Glands of the Rat and Mouse

Effect of mesenchymal bone marrow stem cells on the periodontal ligament of induced Diabetic Rats.

Effect of statins on the periodontal ligament and Alveolar process of induced Diabetic Rats

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