Salivary levels of disease-related biomarkers in the early stages of Parkinson’s and Alzheimer’s disease: A cross-sectional study

Sabaei, Masoomeh; Rahimian, Saba; Ketabforoush, Arsh Haj Mohamad Ebrahim; Rasoolijazi, Homa; Zamani, Babak; Hajiakhoundi, Fahime; Soleimani, Mansooreh; Shahidi, Gholam Ali; Faramarzi, Mohammad

doi:10.1016/j.ibneur.2023.03.004

Cited by 14 publications

(13 citation statements)

References 38 publications

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“…Early diagnosis and predicting the treatment outcome and prognosis of patients with chronic neurological diseases is clinically important and can aid in the better management of such patients. 11 13 26 27 Clinical indicators for the prediction of recurrent seizures are well-recognized, and previous studies have identified young age, family history of FS, low-degree fever, and lower duration of fever prior to seizure. 28 29 Cappellari et al 30 also found that younger age is a predictive factor for RFS, whereas increasing age is associated with a linear decrement in the risk of RFS.…”

Section: Discussionmentioning

confidence: 99%

The Role of Electroencephalography in the Prediction of Relapse of Febrile Convulsion in Patients Aged between 6 to 60 Months: A Prospective Cohort Study

Amouzadeh,

Mollamohammadi,

Razavi

et al. 2024

Journal of Pediatric Neurology

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Febrile seizures (FS) are the most common type of seizure in pediatrics, and patients with FS can present with recurrent febrile seizures (RFS). Some clinical factors have been known to predict RFS, but there is no consensus regarding electroencephalography (EEG). We aimed to determine the ability of EEG to predict RFS. This prospective cohort study was done in children aged between 6 and 60 months. The EEG was performed on patients 2 weeks after the FS, and the patients were followed up for 6 months. Two hundred patients were enrolled. Recurrence of febrile convulsion occurred in 27% of the patients. A higher risk of recurrent seizures was seen in females compared with males (p = 0.04, hazard ratio [HR] = 1.83), children with a family history of seizure (p = 0.011, HR = 2), people with fever-to-seizure interval <1 hour (p = 0.009, HR = 6.1), as well as 1 to 24 hours interval between fever and seizure (p = 0.033, HR = 2.15), aEnd patients with abnormal EEG findings compared with normal EEG (p = 0.001, HR = 4.45). There was no significant relationship between RFS and other studied factors. This study showed the ability of EEG to predict RFS, and the results showed a higher likelihood of recurrence occurring in subjects with abnormal rather than normal EEG.

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Section: Discussionmentioning

confidence: 99%

The Role of Electroencephalography in the Prediction of Relapse of Febrile Convulsion in Patients Aged between 6 to 60 Months: A Prospective Cohort Study

Amouzadeh,

Mollamohammadi,

Razavi

et al. 2024

Journal of Pediatric Neurology

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“…Salivary t-α-syn was analyzed in twelve studies. In five studies [35,44,45,47,48], salivary t-α-syn levels were significantly lower in PD patients than healthy controls. Moreover, Shaheen et al [45], Vivacqua et al [48], and Sabaei et al [44] performed ROC analyses, which provided quite satisfactory results (AUC 0.823, not reported, 0.68; sensitivity 80.0%, 67.44%, 95.8%; specificity 86.7%, 91.04%, 36.4%;, respectively).…”

Section: Alpha-synucleinmentioning

confidence: 95%

“…In five studies [35,44,45,47,48], salivary t-α-syn levels were significantly lower in PD patients than healthy controls. Moreover, Shaheen et al [45], Vivacqua et al [48], and Sabaei et al [44] performed ROC analyses, which provided quite satisfactory results (AUC 0.823, not reported, 0.68; sensitivity 80.0%, 67.44%, 95.8%; specificity 86.7%, 91.04%, 36.4%;, respectively). Nevertheless, substantial discrepancies in specificity are confusing; indeed, in a study by Sabaei et al [44], patients affected by Alzheimer's Disease (AD) had even lower levels of t-α-syn than PD patients.…”

Section: Alpha-synucleinmentioning

confidence: 95%

“…Moreover, Shaheen et al [45], Vivacqua et al [48], and Sabaei et al [44] performed ROC analyses, which provided quite satisfactory results (AUC 0.823, not reported, 0.68; sensitivity 80.0%, 67.44%, 95.8%; specificity 86.7%, 91.04%, 36.4%;, respectively). Nevertheless, substantial discrepancies in specificity are confusing; indeed, in a study by Sabaei et al [44], patients affected by Alzheimer's Disease (AD) had even lower levels of t-α-syn than PD patients. On the other hand, as many as seven studies revealed no significant differences in salivary t-α-syn between the diagnostic groups [36,[38][39][40][41][42]46].…”

Section: Alpha-synucleinmentioning

confidence: 98%

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Salivary Biomarkers for Parkinson’s Disease: A Systematic Review with Meta-Analysis

Nijakowski,

Owecki,

Jankowski

et al. 2024

Cells

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Parkinson’s Disease (PD) is a common neurodegenerative disease which manifests with motor features, such as bradykinesia, resting tremor, rigidity, and postural instability. Using the non-invasive technique of saliva collection, we designed a systematic review to answer the question “Are salivary biomarkers reliable for the diagnosis of Parkinson’s Disease?”. Following inclusion and exclusion criteria, 30 studies were included in this systematic review (according to the PRISMA statement guidelines). Mostly proteins were reported as potential biomarkers in saliva. Based on meta-analysis, in PD patients, salivary levels of total alpha-synuclein were significantly decreased, and those of oligomeric alpha-synuclein were significantly increased. Also, according to pooled AUC, heme oxygenase-1 demonstrated significant predictive value for saliva-based PD diagnosis. In conclusion, some potential biomarkers, especially alpha-synuclein, can be altered in the saliva of PD patients, which could be reliably useful for early diagnosis of this neurodegenerative disease differentiating other synucleopathies.

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“…The description of aSyn immunoreactivity in the salivary glands of PD patients led many investigators to determine aSyn concentrations in the saliva. Five studies found decreased total salivary concentrations in PD patients compared with HCs [ 142 , 143 , 144 , 145 , 146 ], while another six studies found similar values in both study groups [ 37 , 56 , 132 , 147 , 148 , 149 ]. However, salivary oligomeric aSyn levels [ 144 , 145 , 147 , 148 , 149 ], and oligomeric aSyn/total aSyn ratio [ 148 ] were found to increase in PD patients in all the studies addressing this issue.…”

Section: Studies Addressing Asyn Levels In Salivary Glands and Salivamentioning

confidence: 99%

Alpha-Synuclein in Peripheral Tissues as a Possible Marker for Neurological Diseases and Other Medical Conditions

Jiménez-Jiménez,

Alonso-Navarro,

García-Martín

et al. 2023

Biomolecules

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The possible usefulness of alpha-synuclein (aSyn) determinations in peripheral tissues (blood cells, salivary gland biopsies, olfactory mucosa, digestive tract, skin) and in biological fluids, except for cerebrospinal fluid (serum, plasma, saliva, feces, urine), as a marker of several diseases, has been the subject of numerous publications. This narrative review summarizes data from studies trying to determine the role of total, oligomeric, and phosphorylated aSyn determinations as a marker of various diseases, especially PD and other alpha-synucleinopathies. In summary, the results of studies addressing the determinations of aSyn in its different forms in peripheral tissues (especially in platelets, skin, and digestive tract, but also salivary glands and olfactory mucosa), in combination with other potential biomarkers, could be a useful tool to discriminate PD from controls and from other causes of parkinsonisms, including synucleinopathies.

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Salivary levels of disease-related biomarkers in the early stages of Parkinson’s and Alzheimer’s disease: A cross-sectional study

Cited by 14 publications

References 38 publications

The Role of Electroencephalography in the Prediction of Relapse of Febrile Convulsion in Patients Aged between 6 to 60 Months: A Prospective Cohort Study

The Role of Electroencephalography in the Prediction of Relapse of Febrile Convulsion in Patients Aged between 6 to 60 Months: A Prospective Cohort Study

Salivary Biomarkers for Parkinson’s Disease: A Systematic Review with Meta-Analysis

Alpha-Synuclein in Peripheral Tissues as a Possible Marker for Neurological Diseases and Other Medical Conditions

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