Salivary β2- microglobulin Levels in Patients with Erosive Oral Lichen Planus and Squamous Cell Carcinoma

Abstract

Obectives: β2 microglobulin, as a biomarker, is used for the diagnosis oforal malignant and pre-malignant lesions. The components of the microglobulin system can directly or indirectly helpgrow and develop tumors. The present study aims to comparebeta-2 microglobulin levels in patients with lichen planus of the esophagus, oral squamous cell carcinoma, and healthy individuals. Further, it evaluated the salivaryβ2- microglobulin level in malignantand pre-malignant lesions. Oral lichen planus(OLP) is a chronic skin-mucus disorder. Of the total 75 patients referred to Oral Medicine at Dentistry School of Zahedan University of Medical Sciences, 25 were healthy and 25 had oral Lichen Planus(OLP) and the rest had squamous cell carcinoma(SCC). To collect the saliva samples, unstimulated spitting was used. They were collectedbetween 9 and 12 a.mSalivary beta2microglobin was recorded based on the factory instructions by ELISA optical density method with 450nm wavelength for each sample.The data were analyzed using descriptive, Kruskal-Wallis and Mann-Whitney and Pearson’s correlation coefficient (SPSS 21).Results: The salivary β2 microglobulin level in patients with squamous cell carcinoma(SCC) and oral lichen plan(OLP) is significantly higher than that inhealthy group. Thus, this index is usedfor assessing early malignant transformationand oral pre-malignantlesion.