Salivirus Type 1 and Type 2 in patients with acute gastroenteritis, Germany

Aldabbagh, Souhaib; Eckerle, Isabella; Müller, A.; Delwart, Eric; Eis‐Hübinger, A. M.

doi:10.1016/j.jcv.2015.07.048

Cited by 5 publications

(15 citation statements)

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“…Greninger et al found salivirus in 1 × 10 7 to 5 × 10 7 viral genomic copies per milliliter of diarrheic stool samples in the United States . In Germany, the range of the salivirus viral concentrations was 7.1 × 10 6 to 7.2 × 10 8 copies per gram in gastroenteritis cases . In China, the mean viral load of the gastroenteritis group was 6.33 × 10 4 copies (1.14 × 10 0 to 6.91 × 10 5 copies) vs 5.01 × 10 4 copies (1.46 × 10 0 to 1.86 × 10 5 copies) in the control group …”

Section: Molecular Epidemiological Studies Of Salivirus In Humansmentioning

confidence: 94%

“…A causative role for salivirus in gastroenteritis especially in children was suggested but not yet confirmed. Many studies support but some other studies reject a causative role for salivirus in acute gastroenteritis. In acute gastroenteritis cases, the main clinical symptoms of salivirus infections could be diarrhea, vomiting, and fever .…”

Section: Clinical Characteristics Of Salivirus Infectionsmentioning

confidence: 99%

“…In acute gastroenteritis cases, the main clinical symptoms of salivirus infections could be diarrhea, vomiting, and fever . The situation is more complex because salivirus was detected in coinfections with other pathogens, too, in fecal samples collected from different clinical conditions and comorbidites . In China, among the 16 salivirus‐positive children with diarrhea, 10 were coinfected with another diarrhea‐related virus, among which calicivirus was the most common .…”

Section: Clinical Characteristics Of Salivirus Infectionsmentioning

confidence: 99%

“…Few studies report the molecular detection of salivirus and its impact on human health (Table ), but SaV‐A1 has already been identified in all continents. (In contrast, SaV‐A2 was detected in humans in China and in Germany ).…”

Section: Molecular Epidemiological Studies Of Salivirus In Humansmentioning

confidence: 99%

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Saliviruses-the first knowledge about a newly discovered human picornavirus

2016

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The salivirus, first discovered in the year 2009, is a member of the large and growing family Picornaviridae. At present, the genus Salivirus contains 1 species Salivirus A and 2 genotypes, Salivirus A1 and Salivirus A2. Salivirus has been identified in humans and chimpanzees and may cause acute gastroenteritis in humans, having been detected in 0% to 8.7% of fecal samples collected from gastroenteritis in different human populations. Salivirus is ubiquitous in wastewater of human origin and river water specimens worldwide and represents a potential indicator human RNA virus for monitoring of environmental samples. This review summarizes the current knowledge on saliviruses including discovery, taxonomy, genome structure, and genetic diversity; covers all aspects of infection including epidemiology, molecular epidemiology, clinical feature, host species, environmental characteristics, and laboratory diagnosis; and gives a summary of possible future perspectives.

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Section: Molecular Epidemiological Studies Of Salivirus In Humansmentioning

confidence: 94%

Section: Clinical Characteristics Of Salivirus Infectionsmentioning

confidence: 99%

Section: Clinical Characteristics Of Salivirus Infectionsmentioning

confidence: 99%

Section: Molecular Epidemiological Studies Of Salivirus In Humansmentioning

confidence: 99%

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Saliviruses-the first knowledge about a newly discovered human picornavirus

2016

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“…The epidemiological studies in several different geographical areas in the world propose that SalV has a worldwide distribution and it can be the possible etiologic agent of gastroenteritis in humans [7,27]. However, there is a low detection rate of SalV with a prevalence of 0.1-8.8% in patients with gastroenteritis [6][7][8][9][10][11][12][13][14][15][16]. Although SalV infections are reported in different agegroups, the overall most frequent infections have been detected in under 5-year-old children [27,28].…”

Section: Discussionmentioning

confidence: 99%

Bufavirus, Cosavirus, and Salivirus in Diarrheal Italian Infants

et al. 2021

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Three newly discovered viruses have been recently described in diarrheal patients: Cosavirus (CosV) and Salivirus (SalV), 2 picornaviruses, and bufavirus (BuV), a parvovirus. The detection rate and the role of these viruses remain to be established in acute gastroenteritis (AGE) in diarrheal Italian infants. From November 2016 to November 2017, stool samples were collected from 160 children <5 years old suffering from AGE and attending the Children’s Hospital in Turin, Italy. During the study period, 1 (0.5%) sample was positive for 1 of the 3 investigated viruses: 0 (0%) CosV, 1 (0.5%) SalV, and 0 (0%) BuV, whereas 42 (26.0%) children were infected with rotavirus and 2 (1%) with adenovirus. No mixed infections involving the 3 viruses were found. Although these viruses are suspected to be responsible for AGE in children, our data showed that this association was uncertain. Therefore, further studies with large cohorts of healthy and diarrheal children will be needed to evaluate their clinical role in AGE.

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Salivirus infection: Systematic review and meta‐analysis of association with gastrointestinal symptoms in children

Kesheh

Khatami

Saadati

et al. 2021

Reviews in Medical Virology

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Salivirus (SaV) is a newly described member of the family Picornaviridae that has been associated with gastrointestinal (GI) symptoms, particularly in children. The aim of the present study was to evaluate the prevalence of SaV in symptomatic children and its potential association with GI complications. A systematic search was conducted from 01 December 2009 to 10 December 2020, in three major English databases, including Scopus, PubMed and Web of Science as well as Google scholar search engine. Random effect model-based overall prevalence and odds ratio (OR)were assessed in cross-sectional and case-control studies by STATA 14.1. The random effect model-based pooled prevalence of SaV was 1.6% (95% CI, 0.010-0.022%) and overall OR for all eight case-control studies indicated an association (3.19 with 95% confidence interval 1.35-7.57) that was not statistically significant, due to the small number of studies available. More comprehensive case-control studies in multiple geographies should be conducted on the prevalence of SaV in children.

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Salivirus Type 1 and Type 2 in patients with acute gastroenteritis, Germany

Cited by 5 publications

References 0 publications

Saliviruses-the first knowledge about a newly discovered human picornavirus

Saliviruses-the first knowledge about a newly discovered human picornavirus

Bufavirus, Cosavirus, and Salivirus in Diarrheal Italian Infants

Salivirus infection: Systematic review and meta‐analysis of association with gastrointestinal symptoms in children

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