We report three cases of Salmonella meningitis which occurred on the Yale-New Haven Hospital Pediatric Service in the last 12 years. In view of the increasing incidence of Salmonella infection and its serious prognosis, it is important that those organisms be suspected in all cases of purulent meningitis, especially among the very young. We emphasize the relatively asymptomatic nature of the disease in early infancy and review the role of various antimicrobial agents in management, as well as the literature concerning this disease.