Salvage Cryoablation for Recurrent Prostate Cancer Following Primary External Beam Radiotherapy or Primary Cryotherapy: A Propensity Score Matched Analysis of Mid-term Oncologic and Functional Outcomes

Campbell, Scott; Deivasigamani, Sriram; Arcot, Rohith; Adams, Eric D.; Orabi, Hazem; Elshafei, Ahmed; Tan, Wei; Davis, Leah; Yuan, Wei; Chang, Andrew C.; Jones, J. Stephen; Polascik, Thomas J.

doi:10.1016/j.clgc.2023.06.015

Cited by 4 publications

(5 citation statements)

References 25 publications

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“…These results indicate that the use of salvage focal cryoablation is as beneficial in treating primary cryotherapy recurrence as it is for primary radiotherapy recurrence. [43] The majority of studies on focal cryoablation in the salvage setting examine its use for radiotherapy recurrence treatment; this study adds to the literature on salvage focal cryotherapy by showing its effectiveness against primary cryotherapy recurrence as well.…”

Section: Post-prior Focal Ablation Recurrencementioning

confidence: 92%

“…The results showed no difference in BPFS or in functional outcomes between the two cohorts (post-radiotherapy or postprior cryotherapy). [43] Additionally, BPFS was lower in D'Amico high-risk and intermediate-risk groups than in low-risk groups. These results indicate that the use of salvage focal cryoablation is as beneficial in treating primary cryotherapy recurrence as it is for primary radiotherapy recurrence.…”

Section: Post-prior Focal Ablation Recurrencementioning

confidence: 94%

“…Following a 72month medium follow-up, biochemical progression was observed in 55 (13.1%) and 90 (21.5%) of the patients at 2 and 5 years after salvage whole-gland cryotherapy, respectively. [43] N=67 (16%) developed urinary incontinence defined as leakage requiring any number of pads, 11 (2.6%) developed fistulae, and 59 (14.1%) retained erectile function with or without pharmacologic intervention. [43] Ghafar et al ( 2001) performed salvage cryosurgery on n= 38 patients with biopsy-proven recurrence following radiation therapy.…”

Section: A Whole-gland Salvage Cryotherapymentioning

confidence: 99%

“…[43] N=67 (16%) developed urinary incontinence defined as leakage requiring any number of pads, 11 (2.6%) developed fistulae, and 59 (14.1%) retained erectile function with or without pharmacologic intervention. [43] Ghafar et al ( 2001) performed salvage cryosurgery on n= 38 patients with biopsy-proven recurrence following radiation therapy. [44] None of the patients had evidence of metastatic disease based on conventional staging imaging (CT and bone scans).…”

Section: A Whole-gland Salvage Cryotherapymentioning

confidence: 99%

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The Role of Whole-Gland and Focal Cryotherapy in Recurrent Prostate Cancer

Pio,

Murdock,

Fuller

et al. 2024

Preprint

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Prostate cancer is the most common non-cutaneous malignancy in men, with the majority of newly diagnosed patients eligible for active surveillance. Despite definitive treatment, a considerable percentage of men will experience biochemical recurrence and even regional and distant metastatic recurrence after radiation therapy or radical prostatectomy. Salvage prostatectomy, while oncologically effective, poses significant morbidity with poor functional outcomes. Salvage cryotherapy has emerged as a promising alternative for localized recurrence, demonstrating safety and efficacy. This review examines the oncologic and functional outcomes of whole-gland and focal salvage cryotherapy, including disease-free survival, cancer-specific survival, and overall survival. The crucial role of multiparametric prostate MRI and evolving role of next-generation PSMA-targeted PET imaging is also examined. Comparison of outcomes of cryotherapy to other salvage ablation modalities, such as high-intensity focused ultrasound (HIFU) is also explored.

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Section: Post-prior Focal Ablation Recurrencementioning

confidence: 92%

Section: Post-prior Focal Ablation Recurrencementioning

confidence: 94%

Section: A Whole-gland Salvage Cryotherapymentioning

confidence: 99%

Section: A Whole-gland Salvage Cryotherapymentioning

confidence: 99%

See 2 more Smart Citations

The Role of Whole-Gland and Focal Cryotherapy in Recurrent Prostate Cancer

Pio,

Murdock,

Fuller

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

“…In patients who have undergone prior cryoablation or external beam radiation, cryotherapy can also be used for salvage therapy [ 66 ]. Campbell et al reviewed 126 patients, half of whom underwent primary external beam radiation and the other half underwent primary cryoablation.…”

Section: Reported Outcomesmentioning

confidence: 99%

Image-Guided Prostate Cryoablation: State-of-the-Art

Ramalingam,

McCarthy,

Degerstedt

et al. 2023

Medicina

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Image-guided focal therapy has increased in popularity as a treatment option for patients with primary and locally recurrent prostate cancer. This review will cover the basic indications, evaluation, treatment algorithm, and follow-up for patients undergoing image-guided ablation of the prostate. Additionally, this paper will serve as an overview of some technical approaches to cases so that physicians can familiarize themselves with working in this space. While the focus of this paper is prostate cryoablation, readers will obtain a basic literature overview of some of the additional available image-guided treatment modalities for focal prostate therapy.

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Salvage Cryoablation for Recurrent Prostate Cancer Following Radiation—A Comprehensive Review

Lee,

Thakker,

Pineault

et al. 2024

Cancers

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The treatment options for prostate cancer typically entail active surveillance, surgery, radiation, or a combination of the above. Disease recurrence remains a concern, with a wide range of recurrence rates having been reported in the literature. In the setting of recurrence, the salvage treatment options include salvage prostatectomy, salvage high-intensity focused ultrasound (HIFU), stereotactic body radiotherapy (SBRT), salvage brachytherapy, and salvage cryoablation. In this review, we analyze the currently available data related to salvage cryoablation for recurrent prostate cancer following radiation.

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Salvage Cryoablation for Recurrent Prostate Cancer Following Primary External Beam Radiotherapy or Primary Cryotherapy: A Propensity Score Matched Analysis of Mid-term Oncologic and Functional Outcomes

Cited by 4 publications

References 25 publications

The Role of Whole-Gland and Focal Cryotherapy in Recurrent Prostate Cancer

The Role of Whole-Gland and Focal Cryotherapy in Recurrent Prostate Cancer

Image-Guided Prostate Cryoablation: State-of-the-Art

Salvage Cryoablation for Recurrent Prostate Cancer Following Radiation—A Comprehensive Review

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